{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T19:57:38Z","timestamp":1700596658231},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T00:00:00Z","timestamp":1293753600000},"content-version":"vor","delay-in-days":486,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective.<\/jats:italic> Atypical squamous cells of undetermined significance (ASCUS) cells, occurring in organized cytological screening, may be either high\u2010risk human papillomavirus (HPV) positive or negative. To refine the assessment of women with ASCUS, a high\u2010risk HPV\u2010DNA test is recommended as triage in Sweden. <jats:italic>Methods.<\/jats:italic> A total of 197 consecutive women (mean age 39 years, range 21\u201360) with a diagnosis of ASCUS from the primary screening were selected for triage. Their cervical smears were collected and evaluated by using conventional cytological examination in combination with a high\u2010risk HPV\u2010DNA test (hybrid capture 2). The women were categorized into four groups: Group A, Cytology + \/HPV +; Group B, Cytology\u2013\/HPV +; Group C, Cytology + \/HPV\u2013; and Group D, Cytology\u2013\/ HPV\u2013. Women within Groups A\u2013C were admitted for colposcopy and cervical biopsy. The women in Group D were considered as a low\u2010risk group for tumor development, and were re\u2010examined after three years in the next round of the organized screening. <jats:italic>Results.<\/jats:italic> In women in Group A (<jats:italic>n<\/jats:italic> = 58) the prevalence of histological verified CIN2\u20133 was 41%, in Group B (<jats:italic>n<\/jats:italic> = 41) 20%, and in Group C (<jats:italic>n<\/jats:italic> = 9) 0%. In Group D (<jats:italic>n<\/jats:italic> = 89), repeated primary screening three years later revealed CIN2\u20133 in two biopsies from 74 women studied (&lt;3%). The prevalence of a high\u2010risk HPV infection decreased with age in women with ASCUS. It was 74% in women &lt;30 years and 19% in women \u226550 years. <jats:italic>Conclusions.<\/jats:italic> Adding a high\u2010risk HPV test in secondary screening increased the identification of women with CIN2\u20133 lesions by 33% in comparison with repeat cytology (<jats:italic>p<\/jats:italic> = 0.01). The clinical significance of the ASCUS diagnosis varied with age of the women.<\/jats:p>","DOI":"10.1080\/00016340903160952","type":"journal-article","created":{"date-parts":[[2009,8,18]],"date-time":"2009-08-18T21:06:49Z","timestamp":1250629609000},"page":"1006-1010","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Value of high\u2010risk HPV\u2010DNA testing in the triage of ASCUS"],"prefix":"10.1111","volume":"88","author":[{"given":"IR\u00c9NE","family":"SILVERLOO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BENGT","family":"ANDRAE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ERIK","family":"WILANDER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,31]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690666"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/02813439609024170"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/03009739809178947"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.12.005"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn099"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90816-T"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.11.796"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1845"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10735"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600918"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2005.00702.x"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910630610"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24010"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn444"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.1999.780516.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2178"},{"key":"e_1_2_7_19_2","volume-title":"Cancer incidence in five continents","author":"Parkin DM","year":"1997"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910530609"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808516"},{"key":"e_1_2_7_22_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/jnci\/93.4.293","article-title":"ALTS Study group comparison of three management strategies for patients with atypical squamous cells of undetermined significance: baseline results from a randomized trial","volume":"93","author":"Solomon D","year":"2001","journal-title":"J Natl Cancer Inst."}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F00016340903160952","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/00016340903160952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T13:17:22Z","timestamp":1697375842000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1080\/00016340903160952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1080\/00016340903160952"],"URL":"https:\/\/doi.org\/10.1080\/00016340903160952","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9]]},"assertion":[{"value":"2010-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}