{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:50:06Z","timestamp":1760853006805},"reference-count":21,"publisher":"Informa UK Limited","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Oto-Laryngologica"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1080\/00016480410017125","type":"journal-article","created":{"date-parts":[[2004,8,12]],"date-time":"2004-08-12T02:20:26Z","timestamp":1092277226000},"page":"1000-1007","source":"Crossref","is-referenced-by-count":11,"title":["Intracochlear Perfusion of Pneumolysin, a Pneumococcal Protein, Rapidly Abolishes Auditory Potentials in the Guinea Pig Cochlea"],"prefix":"10.1080","volume":"124","author":[{"given":"Liam J.","family":"Skinner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryline","family":"Beurg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Darrouzet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-marie","family":"Aran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Dulon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2009,7,8]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1177\/000992280204100602","volume":"41","author":"Hoberman A","year":"2002","journal-title":"Clin Pediatr"},{"key":"CIT0002","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/00001432-200206000-00007","volume":"15","author":"Meli DN","year":"2002","journal-title":"Curr Opin Infect Dis"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198410043111401"},{"key":"CIT0004","first-page":"628","volume":"120","author":"Kesser BW","year":"1999","journal-title":"Time course of hearing loss in an animal model of pneumococcal meningitis. Otolaryngol Head Neck Surg"},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.mi.47.100193.000513","volume":"47","author":"Paton JC","year":"1993","journal-title":"Annu Rev Microbiol"},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0966-842X(98)01220-7","volume":"6","author":"Paton JC","year":"1998","journal-title":"Trends Microbiol"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S1438-4221(00)80039-9","volume":"290","author":"Alouf JE","year":"2000","journal-title":"Int J Med Microbiol"},{"key":"CIT0008","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1111\/j.1365-2958.1991.tb01969.x","volume":"5","author":"Boulnois GJ","year":"1991","journal-title":"Mol Microbiol"},{"key":"CIT0009","first-page":"229","volume":"17","author":"Bonev B","year":"2000","journal-title":"Structural investigations of pneumolysin\/lipid complexes. Mol Membr Biol"},{"key":"CIT0010","first-page":"5714","volume":"276","author":"Bonev BB","year":"2001","journal-title":"Structural analysis of the protein\/lipid complexes asso-ciated with pore formation by the bacterial toxin pneumolysin. J Biol Chem"},{"key":"CIT0011","first-page":"152","volume":"113","author":"Comis SD","year":"1993","journal-title":"Cytotoxic effects on hair cells of guinea pig cochlea produced by pneumolysin, the thiol activated toxin of Streptococcus pneumoniae. Acta Otolaryngol (Stockh)"},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1128\/IAI.65.11.4411-4418.1997","volume":"65","author":"Winter AJ","year":"1997","journal-title":"Infect Immun"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1128\/IAI.63.2.442-447.1995","volume":"63","author":"Rayner CFJ","year":"1995","journal-title":"Infect Immun"},{"key":"CIT0014","first-page":"303","volume":"27","author":"Mohammed BJ","year":"1999","journal-title":"The effect of the pneumococcal toxin pneumolysin on brain ependymal cilia. Microb Pathog"},{"key":"CIT0015","first-page":"1883","volume":"5","author":"Mitchell TJ","year":"1991","journal-title":"Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute-phase protein. Mol Microbiol"},{"key":"CIT0016","first-page":"3750","volume":"67","author":"Braun JS","year":"1999","journal-title":"Pneumolysin, a protein toxin of Streptococcus pneumo-niae, induces nitric oxide production from macrophages. Infect Immun"},{"key":"CIT0017","first-page":"1501","volume":"62","author":"Houldsworth S","year":"1994","journal-title":"Pneumolysin stimulates production of tumour necrosis factor alpha and interleukin-1 beta by human mononuclear phago-cytes. Infect Immun"},{"key":"CIT0018","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1172\/JCI12035","volume":"109","author":"Braun JS","year":"2002","journal-title":"J Clin Invest"},{"key":"CIT0019","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0378-5955(84)90093-5","volume":"13","author":"Kemp DT","year":"1984","journal-title":"Hear Res"},{"key":"CIT0020","first-page":"1","volume":"42","author":"Rask-Andersen H","year":"1977","journal-title":"Human cochlear aqueduct and its accessory canals. Ann Otol Rhinol Laryngol Suppl"},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1128\/IAI.63.4.1305-1310.1995","volume":"63","author":"Engel F","year":"1995","journal-title":"Infect Immun"}],"container-title":["Acta Oto-Laryngologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/00016480410017125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T23:44:11Z","timestamp":1585871051000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1080\/00016480410017125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":21,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2009,7,8]]},"published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1080\/00016480410017125"],"URL":"https:\/\/doi.org\/10.1080\/00016480410017125","relation":{},"ISSN":["0001-6489","1651-2251"],"issn-type":[{"value":"0001-6489","type":"print"},{"value":"1651-2251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}