{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:27:00Z","timestamp":1778858820599,"version":"3.51.4"},"reference-count":19,"publisher":"Informa UK Limited","issue":"10","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Acta Oto-Laryngologica"],"published-print":{"date-parts":[[2019,10,3]]},"DOI":"10.1080\/00016489.2019.1648867","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T17:00:14Z","timestamp":1567011614000},"page":"918-925","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":48,"title":["Efficacy and safety of nivolumab in 100 patients with recurrent or metastatic head and neck cancer \u2013 a retrospective multicentre study"],"prefix":"10.1080","volume":"139","author":[{"given":"Isaku","family":"Okamoto","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahito","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology, Tokyo Medical University Hachioji Medical Center, Hachioji, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chihiro","family":"Fushimi","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuro","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouki","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology and Surgery, International University of Health and Welfare Mita Hospital, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Matsuki","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, Kanagawa, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Kitasato University School of Medicine, Kanagawa, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Go","family":"Omura","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoaki","family":"Tsukahara","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602252"},{"key":"CIT0002","unstructured":"National Comprehensive Cancer Network (NCCN). Clinical Practice Guidelines in Oncology, Head and Neck Cancers (Version 1.2019)."},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.2925"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2017.08.022"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0187"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1136"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2017.07.023"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10120466"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.0388"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.0393"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.10.014"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1624"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.6870"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq048"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-017-2092-x"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.236.297"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20030"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12543"}],"container-title":["Acta Oto-Laryngologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/00016489.2019.1648867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T14:22:33Z","timestamp":1581603753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/00016489.2019.1648867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,28]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10,3]]}},"alternative-id":["10.1080\/00016489.2019.1648867"],"URL":"https:\/\/doi.org\/10.1080\/00016489.2019.1648867","relation":{},"ISSN":["0001-6489","1651-2251"],"issn-type":[{"value":"0001-6489","type":"print"},{"value":"1651-2251","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,28]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ioto20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ioto20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}