{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:41:37Z","timestamp":1787506897541,"version":"build-2736575974"},"reference-count":91,"publisher":"Informa UK Limited","issue":"5","funder":[{"name":"Short-term grant of Universiti Sains Malaysia","award":["304\/PPSP\/61313086."],"award-info":[{"award-number":["304\/PPSP\/61313086."]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Neuroscience"],"published-print":{"date-parts":[[2021,5,4]]},"DOI":"10.1080\/00207454.2020.1746308","type":"journal-article","created":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T05:09:55Z","timestamp":1584767395000},"page":"482-488","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":12,"title":["The role of mTOR signalling pathway in hypoxia-induced cognitive impairment"],"prefix":"10.1080","volume":"131","author":[{"given":"Entesar Yaseen","family":"Abdo Qaid","sequence":"first","affiliation":[{"name":"School of Health Sciences, Universiti Sains Malaysia","place":["Kubang Kerian, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninie Nadia","family":"Zulkipli","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Universiti Sains Malaysia","place":["Kubang Kerian, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahimah","family":"Zakaria","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Universiti Sains Malaysia","place":["Kubang Kerian, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma Hayati","family":"Ahmad","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Universiti Sains Malaysia","place":["Kubang Kerian, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahiruddin","family":"Othman","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Universiti Sains Malaysia","place":["Kubang Kerian, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangu","family":"Muthuraju","sequence":"additional","affiliation":[{"name":"School of Medical Sciences, Universiti Sains Malaysia","place":["Kubang Kerian, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teguh Haryo","family":"Sasongko","sequence":"additional","affiliation":[{"name":"Perdana University-RCSI School of Medicine, Perdana University Center for Research Excellence","place":["Selangor, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,4,2]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci6010006"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.06.106"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.01.008"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.12.006"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.05.063"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.05.051"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.11.005"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327116689714"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490368"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.03.016"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24436"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1385\/MN:34:3:205"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.08.030"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.05.003"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720211798120990"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.09.177"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.09.034"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.01.019"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4881"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02820.x"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4209-06.2006"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2006.08.007"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2007.12.004"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3809-08.2009"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1908310"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.03.023"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.01.017"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.06.054"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2011.10.002"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3351"},{"issue":"4","key":"e_1_3_2_32_1","first-page":"1071","article-title":"The role of AMPK\/mTOR signal pathway in brain injury following chronic intermittent hypoxia in growing rats","volume":"22","author":"Wen ZW","year":"2018","unstructured":"Wen ZW, Liang DS, Cai XH, et\u00a0al. The role of AMPK\/mTOR signal pathway in brain injury following chronic intermittent hypoxia in growing rats. Eur Rev Med Pharmacol Sci. 2018;22(4):1071\u20131077.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2005.09.009"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.11.2.19022"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.11.058"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.017"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920311795659407"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802733-2.00018-9"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2011.0384"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.01.005"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.21.040181.001543"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2014.00028"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27053-5"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2016.11.006"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00859"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000253094.03023.3f"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05029"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00715.2004"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0658com"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.20.7004-7014.2002"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1256804"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.10.3955-3965.2006"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444360"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.12.12.5447-5454.1992"},{"issue":"4","key":"e_1_3_2_55_1","first-page":"3547","article-title":"PI3K\/Akt and HIF\u20131 signaling pathway in hypoxia\u2013ischemia (Review) )","volume":"18","author":"Zhang Z","year":"2018","unstructured":"Zhang Z, Yao L, Yang J, et\u00a0al. PI3K\/Akt and HIF\u20131 signaling pathway in hypoxia\u2013ischemia (Review) ). Mol Med Rep. 2018;18(4):3547\u20133554.","journal-title":"Mol Med Rep"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1408"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21537"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611782200"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1617608"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.4.11.2139"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0449-07.2007"},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4555-04.2005"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2005326"},{"issue":"6","key":"e_1_3_2_64_1","first-page":"1425","article-title":"Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues","volume":"54","author":"Koong AC","year":"1994","unstructured":"Koong AC, Chen EY, Giaccia AJ. Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. Cancer Res. 1994;54(6):1425\u20131430.","journal-title":"Cancer Res"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0233-3"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00101.2017"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002288"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.06.021"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701414"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-165746"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050177"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601900"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.05.007"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01356.x"},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.01.006"},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01337"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.677"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.135384"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3379"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.05.043"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00430"},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.01.017"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2016.1886"},{"key":"e_1_3_2_84_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1199"},{"key":"e_1_3_2_85_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270725"},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1427-04.2004"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006007"},{"key":"e_1_3_2_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03466.x"},{"key":"e_1_3_2_89_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1739-04.2004"},{"key":"e_1_3_2_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5236.593"},{"key":"e_1_3_2_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/35049004"},{"key":"e_1_3_2_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.08.004"}],"container-title":["International Journal of Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/00207454.2020.1746308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T06:04:56Z","timestamp":1740204296000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/00207454.2020.1746308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,2]]},"references-count":91,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5,4]]}},"alternative-id":["10.1080\/00207454.2020.1746308"],"URL":"https:\/\/doi.org\/10.1080\/00207454.2020.1746308","relation":{},"ISSN":["0020-7454","1543-5245"],"issn-type":[{"value":"0020-7454","type":"print"},{"value":"1543-5245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ines20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ines20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}