{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:29:56Z","timestamp":1790270996739,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology"],"published-print":{"date-parts":[[2003,12]]},"DOI":"10.1080\/00313020310001619154","type":"journal-article","created":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T16:57:32Z","timestamp":1072803452000},"page":"467-471","source":"Crossref","is-referenced-by-count":73,"title":["Transition zone carcinoma of the prostate gland: a common indolent tumour type that occasionally manifests aggressive behaviour"],"prefix":"10.1016","volume":"35","author":[{"given":"Beverley A.","family":"Shannon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"McNeal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1080\/00313020310001619154_bib0005","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1097\/00000478-198812000-00001","article-title":"Zonal distribution of prostatic adenocarcinoma: correlation with histologic pattern and direction of spread","volume":"12","author":"McNeal","year":"1988","journal-title":"Am J Surg Pathol"},{"key":"10.1080\/00313020310001619154_bib0010","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0022-5347(17)42293-2","article-title":"Stage A versus stage B adenocarcinoma of the prostate: morphological comparison and biological significance","volume":"139","author":"McNeal","year":"1988","journal-title":"J Urol"},{"key":"10.1080\/00313020310001619154_bib0015","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0022-5347(17)65239-X","article-title":"What becomes of the patient with latent or occult carcinoma of the prostate?","volume":"86","author":"Montgomery","year":"1961","journal-title":"J Urol"},{"key":"10.1080\/00313020310001619154_bib0020","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0094-0143(21)01061-2","article-title":"The present status of radical prostatectomy for stages A and B prostatic cancer","volume":"2","author":"Jewett","year":"1975","journal-title":"Urol Clin N Amer"},{"key":"10.1080\/00313020310001619154_bib0025","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0022-5347(17)45098-1","article-title":"Long-term followup of young patients with stage A adenocarcinoma of the prostate","volume":"136","author":"Blute","year":"1986","journal-title":"J Urol"},{"key":"10.1080\/00313020310001619154_bib0030","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0022-5347(17)45097-X","article-title":"Prognosis of untreated stage A1 prostatic carcinoma: a study of 94 cases with extended followup","volume":"136","author":"Epstein","year":"1986","journal-title":"J Urol"},{"key":"10.1080\/00313020310001619154_bib0035","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0022-5347(17)38328-3","article-title":"The distribution of residual cancer in radical prostatectomy specimens in stage A prostate cancer","volume":"145","author":"Greene","year":"1991","journal-title":"J Urol"},{"key":"10.1080\/00313020310001619154_bib0040","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1464-410X.1991.tb15394.x","article-title":"Relationship between clinical stage and histological zone of origin in early prostate cancer: morphometric analysis","volume":"68","author":"Greene","year":"1991","journal-title":"Br J Urol"},{"issue":"1994 Suppl","key":"10.1080\/00313020310001619154_bib0045","first-page":"267","article-title":"Zonal origin of prostatic adenocarcinoma: are there biologic differences between transition zone and peripheral zone adenocarcinomas of the prostate gland?","volume":"19","author":"Grignon","year":"1991","journal-title":"J Cellular Biochem"},{"key":"10.1080\/00313020310001619154_bib0050","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/1097-0142(19910215)67:4+<1132::AID-CNCR2820671506>3.0.CO;2-K","article-title":"Prostate cancer: transrectal ultrasound and pathology comparison\u2014a preliminary study of outer gland (peripheral and central zones) and inner gland (transition zone) cancer","volume":"67","author":"Lee","year":"1991","journal-title":"Cancer"},{"key":"10.1080\/00313020310001619154_bib0055","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1002\/1097-0142(20001015)89:8<1800::AID-CNCR21>3.0.CO;2-D","article-title":"Detailed mapping of prostate carcinoma foci: biopsy strategy implications","volume":"89","author":"Chen","year":"2000","journal-title":"Cancer"},{"key":"10.1080\/00313020310001619154_bib0060","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0302-2838(01)00021-5","article-title":"Tumour grade, proliferation, apoptosis, microvessel density, p53, and bcl-2 in prostate cancers: differences between tumours located in the transition zone and in the peripheral zone","volume":"41","author":"Erbersdobler","year":"2002","journal-title":"Eur Urol"},{"key":"10.1080\/00313020310001619154_bib0065","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/S0046-8177(98)90020-X","article-title":"Characterisation of cytoplasmic secretory granules (PSG), in prostatic epithelium and their transformation-induced loss in dysplasia and adenocarcinoma","volume":"29","author":"Cohen","year":"1998","journal-title":"Hum Pathol"},{"key":"10.1080\/00313020310001619154_bib0070","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0046-8177(00)80204-X","article-title":"Luminal contents of benign and malignant prostatic glands: correspondence to altered secretory mechanisms","volume":"31","author":"Cohen","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1080\/00313020310001619154_bib0075","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1046\/j.1464-410x.1998.00530.x","article-title":"The sequential use of pre-operative parameters including intraductal carcinoma to predict the pathological stage and clinical outcome of prostate cancer","volume":"81","author":"Cohen","year":"1998","journal-title":"Brit J Urol"},{"key":"10.1080\/00313020310001619154_bib0080","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S0022-5347(17)36131-1","article-title":"Large, organ confined, impalpable transition zone prostate cancer: association with meta-static levels of prostate specific antigen","volume":"149","author":"Stamey","year":"1993","journal-title":"J Urol"},{"key":"10.1080\/00313020310001619154_bib0085","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/S0022-5347(05)67535-0","article-title":"An analysis of 148 consecutive transition zone cancers: clinical and histological characteristics","volume":"163","author":"Noguchi","year":"2000","journal-title":"J Urol"},{"key":"10.1080\/00313020310001619154_bib0090","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1002\/1097-0142(19921101)70:9<2313::AID-CNCR2820700917>3.0.CO;2-T","article-title":"Multiple cancers in the prostate: morphological features of clinically recognized versus incidental tumours","volume":"70","author":"Villers","year":"1992","journal-title":"Cancer"},{"key":"10.1080\/00313020310001619154_bib0095","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/00000478-199003000-00005","article-title":"Capsular penetration in prostate cancer: significance for natural history and treatment","volume":"14","author":"McNeal","year":"1990","journal-title":"Am J Surg Pathol"},{"key":"10.1080\/00313020310001619154_bib0100","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/pros.1117","article-title":"Patterns of spread of adenocarcinoma in the prostate as related to cancer volume","volume":"49","author":"McNeal","year":"2001","journal-title":"Prostate"},{"key":"10.1080\/00313020310001619154_bib0105","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/S0022-5347(01)64286-1","article-title":"Numerical chromosomal aberrations in transition-zone carcinomas of the prostate","volume":"158","author":"Erbersdobler","year":"1997","journal-title":"J Urol"},{"key":"10.1080\/00313020310001619154_bib0110","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/pros.10216","article-title":"Biochemical recurrence following radical prostatectomy: a comparison between prostate cancers located in different anatomical zones","volume":"55","author":"Augustin","year":"2003","journal-title":"Prostate"},{"key":"10.1080\/00313020310001619154_bib0115","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0090-4295(95)96168-2","article-title":"Making the most out of six systematic sextant biopsies","volume":"45","author":"Stamey","year":"1995","journal-title":"Urology"},{"key":"10.1080\/00313020310001619154_bib0120","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0022-5347(01)67621-3","article-title":"Indications for ultrasound guided transition zone biopsies in the detection of prostate cancer","volume":"153","author":"Lui","year":"1995","journal-title":"J Urol"},{"key":"10.1080\/00313020310001619154_bib0125","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1053\/hupa.2001.24322","article-title":"Comparative analysis of sampling methods for grossing radical prostatectomy specimens performed for nonpalpable (stage T1c) prostatic adenocarcinoma","volume":"32","author":"Smith-Sedhev","year":"2001","journal-title":"Hum Pathol"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302516342623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302516342623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T18:15:12Z","timestamp":1623608112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302516342623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["S0031302516342623"],"URL":"https:\/\/doi.org\/10.1080\/00313020310001619154","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}