{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:35:00Z","timestamp":1760204100859},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology"],"published-print":{"date-parts":[[1995]]},"DOI":"10.1080\/00313029500169422","type":"journal-article","created":{"date-parts":[[2005,10,6]],"date-time":"2005-10-06T22:01:29Z","timestamp":1128636089000},"page":"30-35","source":"Crossref","is-referenced-by-count":2,"title":["Effect of ovariectomy and sex hormone replacement on glutathione and glutathione-related enzymes in rat hepatocarcinogenesis"],"prefix":"10.1016","volume":"27","author":[{"given":"Zarida","family":"Hambali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahrom A.","family":"Wahid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Z.W.","family":"Ngah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid A.","family":"Kadir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5B","key":"10.1080\/00313029500169422_bib0005","first-page":"1071","article-title":"Sex steroids and primary hepatocellular carcinoma","volume":"7","author":"Wilkinson","year":"1987","journal-title":"Anticancer Res"},{"issue":"2","key":"10.1080\/00313029500169422_bib0010","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3181\/00379727-198-43305","article-title":"Sex hormones and tumor promotion in liver","volume":"198","author":"Yager","year":"1991","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1080\/00313029500169422_bib0015","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1136\/bmj.292.6532.1355","article-title":"Oral contraceptive and hepatocellular carcinoma","volume":"292","author":"Neuberger","year":"1986","journal-title":"Br Med J"},{"key":"10.1080\/00313029500169422_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/1992\/72761","article-title":"Hepatocellular carcinoma and sex hormones","volume":"6","author":"Nagasue","year":"1992","journal-title":"HPB Surgery"},{"key":"10.1080\/00313029500169422_bib0025","first-page":"3680","article-title":"Oral contraceptive steroids as promoters of hepatocarcinogenesis in female Sprague-Dawley rats","volume":"40","author":"Yager","year":"1980","journal-title":"Cancer Res"},{"issue":"9","key":"10.1080\/00313029500169422_bib0030","first-page":"3862","article-title":"Enhancement of hepatocarcinogenesis in female rats by ethinyl estradiol and mestranol and not estradiol","volume":"44","author":"Yager","year":"1984","journal-title":"Cancer Res"},{"key":"10.1080\/00313029500169422_bib0035","series-title":"Hormones and sexual factors in human cancer aetiology","first-page":"163","article-title":"Estrogens and primary liver tumors","author":"Taper","year":"1984"},{"issue":"2","key":"10.1080\/00313029500169422_bib0040","doi-asserted-by":"crossref","first-page":"180","DOI":"10.7326\/0003-4819-86-2-180","article-title":"Regression of liver cell adenomas associated with oral contraceptives","volume":"86","author":"Edmonson","year":"1977","journal-title":"Ann Intern Med"},{"issue":"4","key":"10.1080\/00313029500169422_bib0045","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/hep.1840090418","article-title":"The effect of several sex hormones on the growth rate of three Morris hepatoma tumor lines","volume":"9","author":"Erdstein","year":"1989","journal-title":"Hepatology"},{"key":"10.1080\/00313029500169422_bib0050","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0306-9877(91)90262-W","article-title":"Hormonal therapy for hepatocellular carcinoma","volume":"36","author":"Lui","year":"1991","journal-title":"Medical Hypotheses"},{"issue":"9","key":"10.1080\/00313029500169422_bib0055","first-page":"2328","article-title":"Continued development of hepatic gamma-glutamyltranspeptidase-positive foci upon withdrawal of 17 alpha-ethynylestradiol in diethylnitrosamine-initiated rats","volume":"47","author":"Campen","year":"1987","journal-title":"Cancer Res"},{"key":"10.1080\/00313029500169422_bib0060","first-page":"1475","article-title":"Changes in activities of free radical detoxifying enzymes in kidneys of male Syrian hamsters treated with estradiol","volume":"49","author":"Roy","year":"1989","journal-title":"Cancer Res"},{"key":"10.1080\/00313029500169422_bib0065","first-page":"564","article-title":"A common biochemical pattern in preneoplastic hepatocyte nodules generated in four different models of rat","volume":"45","author":"Roomi","year":"1985","journal-title":"Cancer Res"},{"issue":"2","key":"10.1080\/00313029500169422_bib0070","first-page":"193","article-title":"The role of glutathione in evaluating the efficacy of antimetabolites in transplanted tumors","volume":"38","author":"Bose","year":"1991","journal-title":"Neoplasma"},{"key":"10.1080\/00313029500169422_bib0075","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF00052847","article-title":"Enzymes of glutathione metabolism as biochemical markers during hepatocarcinogenesis","volume":"6","author":"Hendrich","year":"1987","journal-title":"Cancer Metastasis Rev"},{"key":"10.1080\/00313029500169422_bib0080","first-page":"649","article-title":"Changes in activities of glutathione peroxidase and glutathione reductase during chemical hepatocarcinogenesis in the rat","volume":"74","author":"Kitahara","year":"1983","journal-title":"Gann"},{"issue":"1","key":"10.1080\/00313029500169422_bib0085","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1210\/endo-96-1-50","article-title":"Role of estrogen as initiator of daily LH surges in the ovariectomized rat","volume":"96","author":"Legan","year":"1975","journal-title":"Endocrinology"},{"key":"10.1080\/00313029500169422_bib0090","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/1097-0142(197808)42:2<462::AID-CNCR2820420213>3.0.CO;2-S","article-title":"The effect of estradiol-17-phenylpropionate and estradiol benzoate on N-Nitrosomorpholine induced liver carcinogenesis in ovariectomized female rats","volume":"42","author":"Taper","year":"1987","journal-title":"Cancer"},{"key":"10.1080\/00313029500169422_bib0095","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/263701a0","article-title":"New principle for the analysis of chemical carcinogenesis","volume":"263","author":"Soit","year":"1976","journal-title":"Nature"},{"key":"10.1080\/00313029500169422_bib0100","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulphydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch Biochem Biophys"},{"key":"10.1080\/00313029500169422_bib0105","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferase; the first enzymatic step in the mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J Biol Chem"},{"key":"10.1080\/00313029500169422_bib0110","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/S0076-6879(55)02291-X","article-title":"Glutathione reductase (liver and yeast)","volume":"2","author":"Racker","year":"1955","journal-title":"Methods in Enzymol"},{"key":"10.1080\/00313029500169422_bib0115","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/0006-291X(76)90747-6","article-title":"Glutathione peroxidase activity in selenium-deficient rat liver","volume":"71","author":"Lawrence","year":"1976","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1080\/00313029500169422_bib0120","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1080\/00313029500169422_bib0125","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/path.1700430311","article-title":"A simple method for the silver impregnation of reticulum","volume":"12","author":"Gordon","year":"1936","journal-title":"Am J Pathology"},{"key":"10.1080\/00313029500169422_bib0130","first-page":"3214","article-title":"Report of a workshop on classification of specific hepatocellular lesions in rats","volume":"35","author":"Squire","year":"1975","journal-title":"Cancer Res"},{"key":"10.1080\/00313029500169422_bib0135","first-page":"225","article-title":"Effect of steroidal sex hormones on the sex-related differences in the hepatic activities of gamma-glutamyltranspeptidase, glutathione S-transferase and glutathione peroxidase in rats","volume":"45","author":"Igarashi","year":"1984","journal-title":"Res Comm Chem Patho Pharm"},{"key":"10.1080\/00313029500169422_bib0140","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0027-5107(88)90197-2","article-title":"Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis","volume":"202","author":"Ketterer","year":"1988","journal-title":"Mutation Research"},{"key":"10.1080\/00313029500169422_bib0145","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3109\/10409239209082566","article-title":"Glutathione transferases and cancer","volume":"27","author":"Tsuchida","year":"1992","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1080\/00313029500169422_bib0150","first-page":"597","article-title":"Multistage rodent hepatocarcinogenesis","volume":"8","author":"Goldfarb","year":"1986","journal-title":"Prog Liver Dis"},{"key":"10.1080\/00313029500169422_bib0155","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/00008469-199210000-00003","article-title":"Ovariectomy promotes the growth of altered hepatic foci after withdrawal and reintroduction of ph\u00e9nobarbital during hepatocarcinogenesis in rats","volume":"1","author":"Hendrich","year":"1992","journal-title":"Eur J Cancer Prev"},{"key":"10.1080\/00313029500169422_bib0160","first-page":"141","article-title":"Early stages of N-2-FAA induced hepatocarcinogenesis in male and female rats and effect of gonadectomy on liver neoplastic conversion and neoplastic development","volume":"73","author":"Katayama","year":"1984","journal-title":"J Natl Cancer Inst"},{"key":"10.1080\/00313029500169422_bib0165","first-page":"313","article-title":"Role of estrogens as promoters of hepatic neoplasia","volume":"46","author":"Wanless","year":"1982","journal-title":"Lab Invest"},{"key":"10.1080\/00313029500169422_bib0170","first-page":"169","article-title":"A Synergism of diethylstil-besterol and other carcinogens in concurrent development of hepatic, mammary, and pituitary tumors in castrated male rats","volume":"70","author":"Sumi","year":"1980","journal-title":"J Natl Cancer Inst"},{"key":"10.1080\/00313029500169422_bib0175","series-title":"J Natl Cancer Inst","first-page":"937","article-title":"Induction of hepatic tumors by diethylstilbestrol alone or in synergism with N-nitrosobutylurea in castrated male WF rats","author":"Sumi","year":"1983"},{"key":"10.1080\/00313029500169422_bib0180","first-page":"576","article-title":"Development of hepatoma in rats following oral administration of synthetic estrogen and progestogen","volume":"71","author":"Higashi","year":"1980","journal-title":"Gann"},{"issue":"3","key":"10.1080\/00313029500169422_bib0185","first-page":"229","article-title":"Long-term administration of tocotrienols and tumor-marker enzyme activities during hepatocarcinogenesis in rats","volume":"9","author":"Asmah","year":"1993","journal-title":"Nutrition"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302516353211?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302516353211?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T11:42:06Z","timestamp":1626608526000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302516353211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995]]}},"alternative-id":["S0031302516353211"],"URL":"https:\/\/doi.org\/10.1080\/00313029500169422","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[1995]]}}}