{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:52:26Z","timestamp":1763765546553},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology"],"published-print":{"date-parts":[[1995]]},"DOI":"10.1080\/00313029500169692","type":"journal-article","created":{"date-parts":[[2005,10,6]],"date-time":"2005-10-06T22:01:57Z","timestamp":1128636117000},"page":"117-120","source":"Crossref","is-referenced-by-count":11,"title":["p53 protein immunoreactivity in cancers of the gallbladder, extrahepatic bile ducts and ampulla of Vater"],"prefix":"10.1016","volume":"27","author":[{"given":"C.","family":"Soon Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Pirdas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1080\/00313029500169692_bib0005","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/319783a0","article-title":"Human p53 gene localized to short arm of chromosome 17","volume":"319","author":"Miller","year":"1986","journal-title":"Nature"},{"key":"10.1080\/00313029500169692_bib0010","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/path.1711570304","article-title":"Expression of the nuclear oncogene p53 in colonic tumors","volume":"157","author":"Van Den Berg","year":"1989","journal-title":"J Pathol"},{"key":"10.1080\/00313029500169692_bib0015","doi-asserted-by":"crossref","first-page":"8763","DOI":"10.1073\/pnas.86.22.8763","article-title":"Wild-type p53 can inhibit oncogene-mediated focus formation","volume":"86","author":"Eliyahu","year":"1989","journal-title":"Proc Natl Acad Sei USA"},{"key":"10.1080\/00313029500169692_bib0020","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/342705a0","article-title":"Mutations in the p53 gene occur in diverse human tumor types","volume":"342","author":"Nigro","year":"1989","journal-title":"Nature"},{"key":"10.1080\/00313029500169692_bib0025","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/329219a0","article-title":"Functional inactivation of genes by dominant negative mutations","volume":"329","author":"Herskowitz","year":"1987","journal-title":"Nature"},{"key":"10.1080\/00313029500169692_bib0030","first-page":"145","article-title":"Widespread p53 overexpression in human malignant tumors. An immunohistochemical study using methacarn-fixed, embedded tissue","volume":"140","author":"Porter","year":"1992","journal-title":"Am J Pathol"},{"key":"10.1080\/00313029500169692_bib0035","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/ijc.2910410204","article-title":"p53 expression in breast cancer","volume":"41","author":"Cattoretti","year":"1988","journal-title":"Int J Cancer"},{"key":"10.1080\/00313029500169692_bib0040","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0140-6736(90)90801-B","article-title":"Increased expression of mutant forms of p53 oncogene in primary lung cancer","volume":"335","author":"Iggo","year":"1990","journal-title":"Lancet"},{"key":"10.1080\/00313029500169692_bib0045","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.2649981","article-title":"Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas","volume":"244","author":"Baker","year":"1989","journal-title":"Science"},{"key":"10.1080\/00313029500169692_bib0050","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1182\/blood.V75.1.180.bloodjournal751180","article-title":"Rearrangement and expression of p53 in the chronic phase and blast crisis of chronic myelogenous leukaemia","volume":"75","author":"Mashal","year":"1990","journal-title":"Blood"},{"key":"10.1080\/00313029500169692_bib0055","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1073\/pnas.76.5.2420","article-title":"Detection of a transformation- related antigen in chemically induced sarcomas and other transformed cells of the mouse","volume":"76","author":"De Leo","year":"1979","journal-title":"Proc Natl Acad Sei USA"},{"key":"10.1080\/00313029500169692_bib0060","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/312646a0","article-title":"Participation of p53 cellular tumor antigen in transformation of normal embryonic cells","volume":"312","author":"Eliyahu","year":"1984","journal-title":"Nature"},{"key":"10.1080\/00313029500169692_bib0065","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1128\/MCB.8.2.531","article-title":"Activating mutations for transformation by p53 produce a gene product that forms an hsc-70-p53 complex with an altered half-life","volume":"8","author":"Finlay","year":"1988","journal-title":"Mol Cell Biol"},{"key":"10.1080\/00313029500169692_bib0070","first-page":"137","article-title":"Regulation of the level of the oncoprotein p53 in non-transformed and transformed cells","volume":"5","author":"Reihsaus","year":"1990","journal-title":"Oncogene"},{"key":"10.1080\/00313029500169692_bib0075","first-page":"1","article-title":"p53: oncogene or anti-oncogene? Genes Dev","volume":"4","author":"Lane","year":"1990"},{"key":"10.1080\/00313029500169692_bib0080","first-page":"893","article-title":"Genetic and immunocytochemical analysis of mutant p53 in human breast cancer cell lines","volume":"5","author":"Bartek","year":"1990","journal-title":"Oncogene"},{"key":"10.1080\/00313029500169692_bib0085","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/path.1711640113","article-title":"p53 expression in human breast cancer related to survival and prognostic factors: an immunohistochemical study","volume":"64","author":"Ostrowski","year":"1991","journal-title":"J Pathol"},{"key":"10.1080\/00313029500169692_bib0090","doi-asserted-by":"crossref","first-page":"7555","DOI":"10.1073\/pnas.87.19.7555","article-title":"p53 mutations in colorectal cancer","volume":"87","author":"Rodrigues","year":"1990","journal-title":"Proc Natl Acad Sei USA"},{"key":"10.1080\/00313029500169692_bib0095","first-page":"807","article-title":"p53 expression in colorectal tumors","volume":"138","author":"Purdie","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1080\/00313029500169692_bib0100","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/path.1711700111","article-title":"p53 and c-erbB-2 protein expression in adenocarcinomas and epithelial dysplasias of the gall bladder","volume":"170","author":"Kamel","year":"1993","journal-title":"J Pathol"},{"key":"10.1080\/00313029500169692_bib0105","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/0140-6736(92)92558-W","article-title":"Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma","volume":"340","author":"Sun","year":"1992","journal-title":"Lancet"},{"key":"10.1080\/00313029500169692_bib0110","first-page":"5976","article-title":"Expression of mutant p53 in melanoma","volume":"51","author":"Stretch","year":"1991","journal-title":"Cancer Res"},{"key":"10.1080\/00313029500169692_bib0115","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1002\/ijc.2910530615","article-title":"Over-expression of p53 protein in human laryngeal carcinoma","volume":"53","author":"Anwar","year":"1993","journal-title":"Int J Cancer"},{"key":"10.1080\/00313029500169692_bib0120","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/351453a0","article-title":"The p53 tumour suppressor gene","volume":"351","author":"Levine","year":"1991","journal-title":"Nature"},{"key":"10.1080\/00313029500169692_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1711720103","article-title":"p53 in tumor pathology: Can we trust immunohistochemistry? Revisited","volume":"172","author":"Hall","year":"1994","journal-title":"J Pathol"},{"key":"10.1080\/00313029500169692_bib0130","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0140-6736(92)92354-I","article-title":"Abnormal expression of wild type p53 protein in normal cells of a cancer family patient","volume":"340","author":"Barnes","year":"1992","journal-title":"Lancet"},{"key":"10.1080\/00313029500169692_bib0135","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/hed.2880140603","article-title":"Overexpression of p53 in head and neck cancer","volume":"14","author":"Watling","year":"1992","journal-title":"Head Neck"}],"container-title":["Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302516352874?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031302516352874?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T05:46:53Z","timestamp":1586497613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031302516352874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995]]}},"alternative-id":["S0031302516352874"],"URL":"https:\/\/doi.org\/10.1080\/00313029500169692","relation":{},"ISSN":["0031-3025"],"issn-type":[{"value":"0031-3025","type":"print"}],"subject":[],"published":{"date-parts":[[1995]]}}}