{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:25:28Z","timestamp":1789809928801,"version":"4.0.1"},"reference-count":37,"publisher":"Informa UK Limited","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Xenobiotica"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1080\/00498250210158230","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T04:52:41Z","timestamp":1034311961000},"page":"863-878","source":"Crossref","is-referenced-by-count":62,"title":["Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites"],"prefix":"10.1080","volume":"32","author":[{"given":"Xue-Jun","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. R.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. W.","family":"Grimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. D.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2008,9,22]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0006-2952(94)00477-4","volume":"49","author":"BENSOUSSAN C.","year":"1995","journal-title":"Biochemical Pharmacology"},{"key":"CIT0002","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0021-9258(19)70058-1","volume":"256","author":"BORGNA J. L.","year":"1981","journal-title":"Journal of Biological Chemistry"},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF01061504","volume":"2","author":"BOXENBAUM H. G.","year":"1974","journal-title":"Journal of Pharmacokinetics and Biopharmaceutics"},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2165\/00003495-198937040-00004","volume":"37","author":"BUCKLEY M. M.","year":"1989","journal-title":"Drugs"},{"key":"CIT0005","first-page":"1527","volume":"275","author":"CHIBA M.","year":"1995","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/12.2.83"},{"key":"CIT0008","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0006-2952(96)00650-8","volume":"53","author":"CREWE H. K.","year":"1997","journal-title":"Biochemical Pharmacology"},{"key":"CIT0009","first-page":"3402","volume":"57","author":"DEHAL S.","year":"1997","journal-title":"Cancer Research"},{"key":"CIT0010","first-page":"681","volume":"27","author":"DEHAL S.","year":"1999","journal-title":"Drug Metabolism and Disposition"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2165\/00003088-198916060-00001","volume":"16","author":"EVANS W. E.","year":"1989","journal-title":"Clinical Pharmacokinetics"},{"key":"CIT0015","first-page":"227","volume":"2","author":"FRANKLIN M. R","year":"1977","journal-title":"Pharmacological Therapeutics"},{"key":"CIT0016","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0163-7258(84)90043-3","volume":"25","author":"FURR B. J.","year":"1984","journal-title":"Pharmacological Therapeutics"},{"key":"CIT0017","first-page":"180","volume":"27","author":"GUNS M. A.","year":"1999","journal-title":"Drug Metabolism and Disposition"},{"key":"CIT0018","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/0006-2952(94)90543-6","volume":"47","author":"GORSKI J. C.","year":"1994","journal-title":"Biochemical Pharmacology"},{"key":"CIT0019","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0006-291X(86)90265-2","volume":"138","author":"GUENGERICH F. P","year":"1986","journal-title":"Biochemistry and Biophysical Research Communications"},{"key":"CIT0020","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1016\/S0021-9258(19)89213-X","volume":"261","author":"GUENGERICH F. P.","year":"1986","journal-title":"Journal of Biological Chemistry"},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/0006-2952(91)90131-N","volume":"41","author":"JACOLOT F.","year":"1991","journal-title":"Biochemical Pharmacology"},{"key":"CIT0022","first-page":"1116","volume":"290","author":"JONES D. R.","year":"1999","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1046\/j.1365-2125.1999.00073.x","volume":"48","author":"KENWORTHY K. E.","year":"1999","journal-title":"British journal of Clinical Pharmacology"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1093\/carcin\/16.7.1449","volume":"16","author":"KING C. M","year":"1995","journal-title":"Carcinogenesis"},{"key":"CIT0025","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1365-2125.1995.tb05796.x","volume":"40","author":"KIVISTO K. T.","year":"1995","journal-title":"British Journal of Clinical Pharmacology"},{"key":"CIT0027","first-page":"552","volume":"26","author":"KOUDRIAKOVA T.","year":"1998","journal-title":"Drug Metabolism and Disposition"},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"LOWRY O. H.","year":"1951","journal-title":"journal of Biological Chemistry"},{"key":"CIT0031","first-page":"645","volume":"21","author":"MANI C.","year":"1993","journal-title":"Drug Metabolism and Disposition"},{"key":"CIT0032","first-page":"657","volume":"21","author":"MANI C.","year":"1993","journal-title":"II. Flavin-containing monooxygenase-mediated N-oxidation. Drug Metabolism and Disposition"},{"key":"CIT0033","first-page":"1031","volume":"28","author":"MAYHEW B. S.","year":"2000","journal-title":"Drug Metabolism and Disposition"},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/S0021-9258(20)82245-5","volume":"239","author":"OMURA T.","year":"1964","journal-title":"journal of Biological Chemistry"},{"key":"CIT0037","first-page":"1119","volume":"21","author":"POON G. K.","year":"1993","journal-title":"Drug Metabolism and Disposition"},{"key":"CIT0038","first-page":"478","volume":"12","author":"REUNITZ P. C.","year":"1984","journal-title":"Drug Metabolism and Disposition"},{"key":"CIT0039","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1021\/bi00334a027","volume":"24","author":"SCHAEFER W. H.","year":"1985","journal-title":"Biochemistry"},{"key":"CIT0040","unstructured":"SEGEL, I. H. 1975, Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (New York: Wiley)."},{"key":"CIT0041","first-page":"414","volume":"270","author":"SHIMADA T.","year":"1994","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"CIT0042","first-page":"pp. 3","volume":"1","author":"SILVERMAN R. B","year":"1988","journal-title":"CRC Press"},{"key":"CIT0043","first-page":"99","volume":"15","author":"SRIDOR C.","year":"1999","journal-title":"\/SSX Proceedings"},{"key":"CIT0044","first-page":"294","volume":"282","author":"SUTTON D.","year":"1997","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"CIT0045","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1172\/JCI113156","volume":"80","author":"WATKINS P. B.","year":"1987","journal-title":"Journal of Clinical Investigation"},{"key":"CIT0046","first-page":"359","volume":"10","author":"WIRZ B.","year":"1996","journal-title":"ISSX Proceedings"}],"container-title":["Xenobiotica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/00498250210158230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T23:09:03Z","timestamp":1622243343000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1080\/00498250210158230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":37,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2008,9,22]]},"published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1080\/00498250210158230"],"URL":"https:\/\/doi.org\/10.1080\/00498250210158230","relation":{},"ISSN":["0049-8254","1366-5928"],"issn-type":[{"value":"0049-8254","type":"print"},{"value":"1366-5928","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}