{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:17:38Z","timestamp":1791357458312,"version":"4.3.1"},"reference-count":14,"publisher":"Informa UK Limited","issue":"9","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Xenobiotica"],"published-print":{"date-parts":[[2019,9,2]]},"DOI":"10.1080\/00498254.2018.1536815","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T20:06:28Z","timestamp":1540411588000},"page":"1044-1053","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":8,"title":["Absorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects"],"prefix":"10.1080","volume":"49","author":[{"given":"Shuichi","family":"Ohnishi","sequence":"first","affiliation":[{"name":"Drug Metabolism & Pharmacokinetics, Shionogi & Co., Ltd. Osaka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Fukumura","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology & Pharmacokinetics, Shionogi & Co., Ltd., Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Kubota","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology & Pharmacokinetics, Shionogi & Co., Ltd., Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Wajima","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology & Pharmacokinetics, Shionogi & Co., Ltd., Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2008.00495.x"},{"key":"CIT0002","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.36076\/ppj.2008\/11\/S105","volume":"11","author":"Benyamin R","year":"2008","journal-title":"Pain Phys"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1038\/ajgsup.2014.8"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12417"},{"key":"CIT0005","unstructured":"Department of Health and Human Sevices (2016), Public Health Service, Food and Drug Administration, Center for Drug Evaulation and Research. Pharmacology\/toxicology NDA review and evaluation [NDA 208854, naldemedine tosylate]. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2017\/208854Orig1s000PharmR.pdf [last accessed 9 Jul 2018]."},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1093\/pm\/pnw240","volume":"18","author":"Emmanuel A","year":"2017","journal-title":"Pain Med"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.387"},{"key":"CIT0008","doi-asserted-by":"crossref","DOI":"10.1201\/b14095","volume-title":"Pharmacokinetics","author":"Gibaldi M","year":"1982","edition":"2"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.1001.1021"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1177\/2040622315627801"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S141322"},{"key":"CIT0012","first-page":"1347","volume":"74","author":"Swegle JM","year":"2006","journal-title":"Am Fam Physician"},{"key":"CIT0013","unstructured":"Symproic\u00ae (naldemedine) [package insert]. (2018). Florham Park, NJ: Shionogi Inc."},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-001-0037-7"}],"container-title":["Xenobiotica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/00498254.2018.1536815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T21:36:22Z","timestamp":1775252182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/00498254.2018.1536815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,4]]},"references-count":14,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9,2]]}},"alternative-id":["10.1080\/00498254.2018.1536815"],"URL":"https:\/\/doi.org\/10.1080\/00498254.2018.1536815","relation":{},"ISSN":["0049-8254","1366-5928"],"issn-type":[{"value":"0049-8254","type":"print"},{"value":"1366-5928","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,4]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ixen20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ixen20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}