{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:51:19Z","timestamp":1790506279504,"version":"4.1.0"},"reference-count":73,"publisher":"Informa UK Limited","issue":"1","funder":[{"name":"Region Nouvelle Aquitaine"},{"name":"French Research Agency","award":["ANR-19-CE17-0020 IMOTEP"],"award-info":[{"award-number":["ANR-19-CE17-0020 IMOTEP"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Xenobiotica"],"published-print":{"date-parts":[[2021,1,2]]},"DOI":"10.1080\/00498254.2020.1813352","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T11:57:52Z","timestamp":1598011072000},"page":"105-114","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":11,"title":["MRP4 is responsible for the efflux transport of mycophenolic acid \u03b2-<scp>d<\/scp>glucuronide (MPAG) from hepatocytes to blood"],"prefix":"10.1080","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2857-8245","authenticated-orcid":false,"given":"Joseph","family":"Berthier","sequence":"first","affiliation":[{"name":"INSERM, UMR 1248, Univ. Limoges, Limoges, France"},{"name":"CHU Limoges, Service de Pharmacologie, Toxicologie et Pharmacovigilance, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Benmameri","sequence":"additional","affiliation":[{"name":"INSERM, UMR 1248, Univ. Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois-Ludovic","family":"Sauvage","sequence":"additional","affiliation":[{"name":"INSERM, UMR 1248, Univ. Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabin","family":"Fabre","sequence":"additional","affiliation":[{"name":"INSERM, UMR 1248, Univ. Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Chantemargue","sequence":"additional","affiliation":[{"name":"INSILIBIO, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Arnion","sequence":"additional","affiliation":[{"name":"INSERM, UMR 1248, Univ. Limoges, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Marquet","sequence":"additional","affiliation":[{"name":"INSERM, UMR 1248, Univ. Limoges, Limoges, France"},{"name":"CHU Limoges, Service de Pharmacologie, Toxicologie et Pharmacovigilance, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Trouillas","sequence":"additional","affiliation":[{"name":"INSERM, UMR 1248, Univ. Limoges, Limoges, France"},{"name":"RCPTM, Univ. Palack\u00fd of Olomouc, Olomouc, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Picard","sequence":"additional","affiliation":[{"name":"INSERM, UMR 1248, Univ. Limoges, Limoges, France"},{"name":"CHU Limoges, Service de Pharmacologie, Toxicologie et Pharmacovigilance, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Saint-Marcoux","sequence":"additional","affiliation":[{"name":"INSERM, UMR 1248, Univ. Limoges, Limoges, France"},{"name":"CHU Limoges, Service de Pharmacologie, Toxicologie et Pharmacovigilance, Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,9,6]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1063\/1.448118"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.06.015"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199834060-00002"},{"key":"CIT0004","unstructured":"Case DA, Ben-Shalom IY, Brozell SR, et\u00a0al. (2018), AMBER 2018, University of California, San Francisco."},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky030"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.02.029"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.031823"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.517"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1021\/ja00074a030"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199733030-00003"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199834020-00002"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00035.2005"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2007.03.006"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2014.01.006"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.110379"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.043661"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199324060-00004"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1042\/bj1130515"},{"key":"CIT0021","unstructured":"Gould IR, Skjevik AA, Dickson CJ, et\u00a0al. (2018). Lipid17: a comprehensive AMBER force field for the simulation of zwitterionic and anionic lipids."},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-4-17"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/8.suppl_B.263"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.7b00366"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1021\/ja00344a001"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.27287"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199804270-00019"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.229104"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3182576098"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/128.Supplement_2.S341"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20820"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200310000-00011"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200403000-00003"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02931-15"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360320508"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00255"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics2030291"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1021\/mp400513k"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.03.049"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-013-1007-6"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.016352"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.05.006"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200408000-00017"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2015.1028366"},{"key":"CIT0046","first-page":"51","volume":"6","author":"Nagelschmitz J","year":"2014","journal-title":"Clin Pharmacol"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S202730"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2008.09.007"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.119.086496"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.3109\/00498254.2012.713531"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200412000-00004"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.001651"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2009.205"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2646"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1033060100"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.131342"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-816095"},{"key":"CIT64876246","doi-asserted-by":"crossref","unstructured":"Schaub T P, Kartenbeck J, K\u00f6nig J, et al. (1999). Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma. J\u00a0Am\u00a0Soc\u00a0Nephrol\u00a010:1159\u20131169.","DOI":"10.1681\/ASN.V1061159"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780411"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702399"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12164"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200746010-00002"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00027.2002"},{"key":"CIT0064","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"Trott O","year":"2010","journal-title":"J Comput Chem"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.03.024"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.8b01039"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2005.12.005"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20035"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.114.061580"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.04.012"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm219"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.017459"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2005.12.007"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.110106"}],"container-title":["Xenobiotica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/00498254.2020.1813352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T08:25:30Z","timestamp":1723451130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/00498254.2020.1813352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,6]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,2]]}},"alternative-id":["10.1080\/00498254.2020.1813352"],"URL":"https:\/\/doi.org\/10.1080\/00498254.2020.1813352","relation":{},"ISSN":["0049-8254","1366-5928"],"issn-type":[{"value":"0049-8254","type":"print"},{"value":"1366-5928","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,6]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ixen20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ixen20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}