{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:06:00Z","timestamp":1789092360157,"version":"build-2803163510"},"reference-count":57,"publisher":"Informa UK Limited","issue":"9","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"funder":[{"DOI":"10.13039\/501100007207","name":"Toray Industries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007207","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Xenobiotica"],"published-print":{"date-parts":[[2026,10,21]]},"DOI":"10.1080\/00498254.2026.2711041","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:19:37Z","timestamp":1785377977000},"page":"722-731","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["<i>In vitro<\/i>\n                    and\n                    <i>in vivo<\/i>\n                    intestinal and hepatic oxidative metabolism of typical cytochrome P450 3A substrates, midazolam, nifedipine, and quinidine, in minipigs: a comparison with humans, monkeys, and dogs"],"prefix":"10.1080","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1588-7486","authenticated-orcid":false,"given":"Chizuka","family":"Sakai","sequence":"first","affiliation":[{"name":"Life Sciences Research Laboratory, New Frontiers Research Laboratories, Basic Research Center, Toray Industries, Inc","place":["Kamakura, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Higashi","sequence":"additional","affiliation":[{"name":"Life Sciences Research Laboratory, New Frontiers Research Laboratories, Basic Research Center, Toray Industries, Inc","place":["Kamakura, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Iwano","sequence":"additional","affiliation":[{"name":"Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University","place":["Machida, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6659-7954","authenticated-orcid":false,"given":"Yohei","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Medical Development Department, Toray Industries, Inc","place":["Chuo-ku, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1068-4261","authenticated-orcid":false,"given":"Hiroshi","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University","place":["Machida, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0541-9715","authenticated-orcid":false,"given":"Masashi","family":"Uchida","sequence":"additional","affiliation":[{"name":"Life Sciences Research Laboratory, New Frontiers Research Laboratories, Basic Research Center, Toray Industries, Inc","place":["Kamakura, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.109.028829"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.7b00772"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.111.040766"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2010.05.009"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1007552927404"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1011981317451"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1018943613122"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.106013"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.110.032649"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)89213-X"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119457"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-012-0707-7"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12912"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.000125"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.10r16fm"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2510160502"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21121"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.10086"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/js960440h"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2.6.875"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1010951732288"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.24.404"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.08.018"},{"issue":"2","key":"e_1_3_4_25_1","first-page":"s241","article-title":"Phase I clinical study of nifedipine sustained-release preparation (BAYa1040-OD tablets): single-dose study","volume":"23","author":"Nakamichi N","year":"1995","unstructured":"Nakamichi N et al. 1995. Phase I clinical study of nifedipine sustained-release preparation (BAYa1040-OD tablets): single-dose study. Yakuri to Chiryo. 23(Suppl. 2):s241\u2013s255. [in Japanese]","journal-title":"Yakuri to Chiryo"},{"issue":"10","key":"e_1_3_4_26_1","first-page":"1316","article-title":"Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans","volume":"29","author":"Naritomi Y","year":"2001","unstructured":"Naritomi Y et al. 2001. Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans. Drug Metab Dispos. 29(10):1316\u20131324.","journal-title":"Drug Metab Dispos"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)38103-0"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-9556(24)14938-0"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.106.011288"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03189683"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02971-4"},{"key":"e_1_3_4_32_1","first-page":"173","article-title":"Species differences in the pharmacokinetic parameters of cytochrome P450 probe substrates between experimental animals, such as mice, rats, dogs, monkeys, and microminipigs, and humans","volume":"5","author":"Sakai C","year":"2014","unstructured":"Sakai C et al. 2014. Species differences in the pharmacokinetic parameters of cytochrome P450 probe substrates between experimental animals, such as mice, rats, dogs, monkeys, and microminipigs, and humans. J Drug Metab Toxicol. 5:173.","journal-title":"J Drug Metab Toxicol"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.2007"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45212-0"},{"issue":"11","key":"e_1_3_4_35_1","first-page":"1292","article-title":"Biotransformation of nifedipine in rat and dog","volume":"42","author":"Scherling D","year":"1992","unstructured":"Scherling D et al. 1992. Biotransformation of nifedipine in rat and dog. Arzneimittelforschung. 42(11):1292\u20131300.","journal-title":"Arzneimittelforschung"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-9556(25)06821-7"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.dmpk-13-rg-083"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-012-0911-5"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2006.03.003"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1999.00923.x"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.711"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2007.07.003"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2023.109579"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.117394"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.121.000749"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116124"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2016.06.008"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114887"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.117209"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12173"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12410"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901371v"},{"issue":"12","key":"e_1_3_4_53_1","first-page":"2215","article-title":"Simultaneous determination and pharmacokinetics of midazolam and its hydroxymetabolites in plasma and urine of man and dog by means of high-performance liquid chromatography","volume":"31","author":"Vree TB","year":"1981","unstructured":"Vree TB, Baars AM, Booij LH, Driessen JJ. 1981. Simultaneous determination and pharmacokinetics of midazolam and its hydroxymetabolites in plasma and urine of man and dog by means of high-performance liquid chromatography. Arzneimittelforschung. 31(12a):2215\u20132219.","journal-title":"Arzneimittelforschung"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1999.tb00085.x"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.6b00136"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20100084"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.42.93"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.68.903"}],"container-title":["Xenobiotica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/00498254.2026.2711041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/00498254.2026.2711041","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/00498254.2026.2711041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:10:37Z","timestamp":1789089037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/00498254.2026.2711041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":57,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,10,21]]}},"alternative-id":["10.1080\/00498254.2026.2711041"],"URL":"https:\/\/doi.org\/10.1080\/00498254.2026.2711041","relation":{},"ISSN":["0049-8254","1366-5928"],"issn-type":[{"value":"0049-8254","type":"print"},{"value":"1366-5928","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ixen20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ixen20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}