{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:52:11Z","timestamp":1791420731892,"version":"4.3.3"},"reference-count":19,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"funder":[{"name":"JSPS KAKENHI","award":["23K06224"],"award-info":[{"award-number":["23K06224"]}]},{"DOI":"10.13039\/100016728","name":"Kyoto Pharmaceutical University","doi-asserted-by":"publisher","award":["2016-1"],"award-info":[{"award-number":["2016-1"]}],"id":[{"id":"10.13039\/100016728","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Xenobiotica"],"DOI":"10.1080\/00498254.2026.2745915","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:40:48Z","timestamp":1791420048000},"page":"1-32","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacometric analysis of dapagliflozin for triglyceride-lowering effects in Japanese patients with type 2 diabetes mellitus based on long-term real-world data and experimental analysis of dyslipidemia model rats"],"prefix":"10.1080","author":[{"given":"Ryosuke","family":"Terada","sequence":"first","affiliation":[{"name":"Laboratory of Pharmacokinetics, Kyoto Pharmaceutical University","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kobuchi","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics, Kyoto Pharmaceutical University","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Anada","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics, Kyoto Pharmaceutical University","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics, Kyoto Pharmaceutical University","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics, Kyoto Pharmaceutical University","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Tanide","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics, Kyoto Pharmaceutical University","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiichi","family":"Hiroi","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics, Kyoto Pharmaceutical University","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Nishiwaki","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics, Kyoto Pharmaceutical University","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raiya","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics, Kyoto Pharmaceutical University","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-Ichiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Diabetes Mellitus and Endocrinology, Tonami General Hospital","place":["Toyama, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Diabetes Mellitus and Endocrinology, Tonami General Hospital","place":["Toyama, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Sakaeda","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacokinetics, Kyoto Pharmaceutical University","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_3_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.05.010"},{"key":"e_1_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311339"},{"key":"e_1_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2017.01.018"},{"key":"e_1_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2023.117236"},{"key":"e_1_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.113.301562"},{"key":"e_1_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022761"},{"key":"e_1_3_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12676"},{"key":"e_1_3_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-020-00860-w"},{"key":"e_1_3_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab551"},{"key":"e_1_3_1_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024816"},{"key":"e_1_3_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90668-m"},{"key":"e_1_3_1_13_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.111519"},{"key":"e_1_3_1_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004007"},{"key":"e_1_3_1_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911303"},{"key":"e_1_3_1_16_1","doi-asserted-by":"publisher","DOI":"10.62347\/AAPZ2726"},{"key":"e_1_3_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15356"},{"key":"e_1_3_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61177-6"},{"key":"e_1_3_1_19_1","unstructured":"Wasan KM Subramanian R Kwong M et\u00a0al. 2003. Poloxamer 407-mediated alterations in the activities of enzymes regulating lipid metabolism in rats. J Pharm Pharm Sci. 6(2):189-197."},{"key":"e_1_3_1_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812389"}],"container-title":["Xenobiotica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/00498254.2026.2745915","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/00498254.2026.2745915","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/00498254.2026.2745915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:40:49Z","timestamp":1791420049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/00498254.2026.2745915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":19,"alternative-id":["10.1080\/00498254.2026.2745915"],"URL":"https:\/\/doi.org\/10.1080\/00498254.2026.2745915","relation":{},"ISSN":["0049-8254","1366-5928"],"issn-type":[{"value":"0049-8254","type":"print"},{"value":"1366-5928","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ixen20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ixen20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}