{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T19:26:55Z","timestamp":1778959615268,"version":"3.51.4"},"reference-count":53,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug and Chemical Toxicology"],"published-print":{"date-parts":[[2020,1,2]]},"DOI":"10.1080\/01480545.2019.1659310","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T10:27:14Z","timestamp":1567420034000},"page":"43-50","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":11,"title":["Thyme (<i>Thymus vulgaris<\/i>) leaf extract modulates purinergic and cholinergic enzyme activities in the brain homogenate of 5-fluorouracil administered rats"],"prefix":"10.1080","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1339-403X","authenticated-orcid":false,"given":"Stephen Adeniyi","family":"Adefegha","sequence":"first","affiliation":[{"name":"Functional Food and Nutraceutical Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunday Idowu","family":"Oyeleye","sequence":"additional","affiliation":[{"name":"Functional Food and Nutraceutical Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria;"},{"name":"Department of Biomedical Technology, Federal University of Technology, Akure, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abimbola","family":"Akintemi","sequence":"additional","affiliation":[{"name":"Functional Food and Nutraceutical Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bathlomew Maduka","family":"Okeke","sequence":"additional","affiliation":[{"name":"Functional Food and Nutraceutical Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganiyu","family":"Oboh","sequence":"additional","affiliation":[{"name":"Functional Food and Nutraceutical Unit, Department of Biochemistry, Federal University of Technology, Akure, Nigeria;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2019,9,2]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.4236\/ojmip.2011.13005"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.07.014"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5621"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-017-9701-5"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.08.012"},{"key":"CIT0007","unstructured":"Berrie, C., 2004. Blood serum enzyme activity profiles as indicators of prognosis and chemotherapy response in breast cancer. http:\/\/www.docguide.com [Accessed 18 February 2004]."},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1201\/9781439847503"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(86)90640-8"},{"issue":"4","key":"CIT0011","first-page":"271","volume":"69","author":"Chen H.","year":"2014","journal-title":"Die Pharmazie-An International Journal of Pharmaceutical Sciences"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1177\/1534735404270335"},{"key":"CIT1000","doi-asserted-by":"publisher","DOI":"10.3126\/ijls.v8i3.10433"},{"issue":"2","key":"CIT0013","first-page":"179","volume":"4","author":"Ekoh S.N.","year":"2014","journal-title":"Int J Biosci"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/657026"},{"key":"CIT0015","first-page":"1331","volume":"9","author":"Forsg\u00e5rd R.A.","year":"2017","journal-title":"Annal Oncology"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2013.02.011"},{"issue":"3","key":"CIT0017","first-page":"302","volume":"7","author":"Geman A.M.","year":"2016","journal-title":"Aging and Disease"},{"key":"CIT0018","first-page":"315","volume-title":"Methods of enzymatic analysis","author":"Giusti G.","year":"1984"},{"issue":"22","key":"CIT0019","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"Habig W.H.","year":"1974","journal-title":"Journal of Biological Chemistry"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1002\/jat.736"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00407"},{"issue":"10","key":"CIT0022","first-page":"974","volume":"3","author":"Javed H.","year":"2013","journal-title":"Journal Asian Scientific Research"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.07.056"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.5b00029"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1042\/bj1330779"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2015.01.001"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.09.034"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(76)90747-6"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2004.09.006"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1074"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-012-0244-5"},{"issue":"4","key":"CIT0032","doi-asserted-by":"crossref","first-page":"553","DOI":"10.33549\/physiolres.931768","volume":"59","author":"M\u00e1rmol F.","year":"2010","journal-title":"Physiological Research"},{"issue":"3","key":"CIT0033","first-page":"779","volume":"13","author":"Millart H.","year":"1993","journal-title":"Anticancer Research"},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.1016\/S0021-9258(19)44679-6","volume":"247","author":"Misra H.P.","year":"1972","journal-title":"Journal Biological Chemistry"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140310"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-018-0198-2"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.979"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1111\/and.13281"},{"issue":"5","key":"CIT0041","first-page":"471","volume":"133","author":"Paul V.","year":"2011","journal-title":"The Indian Journal of Medical Research"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1211\/0022357001774598"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.06.008"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1186\/2050-6511-15-47"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.6744"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.86.265"},{"issue":"2","key":"CIT0047","first-page":"127","volume":"106","author":"Reid-Arndt S.A.","year":"2009","journal-title":"Missouri Medicine"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.03.042"},{"issue":"4","key":"CIT0049","first-page":"231","volume":"14","author":"Sperlagh B.E.A.T.A.","year":"2012","journal-title":"Neuropsychopharmacol Hung"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1533\/9780857095671.499"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.12.106"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6306-2_20"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4376-4"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2008.01.024"}],"container-title":["Drug and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/01480545.2019.1659310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T04:42:45Z","timestamp":1664253765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/01480545.2019.1659310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,2]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,2]]}},"alternative-id":["10.1080\/01480545.2019.1659310"],"URL":"https:\/\/doi.org\/10.1080\/01480545.2019.1659310","relation":{},"ISSN":["0148-0545","1525-6014"],"issn-type":[{"value":"0148-0545","type":"print"},{"value":"1525-6014","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idct20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idct20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}