{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T06:24:12Z","timestamp":1768717452840,"version":"3.49.0"},"reference-count":67,"publisher":"Informa UK Limited","issue":"6","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug and Chemical Toxicology"],"published-print":{"date-parts":[[2022,11,2]]},"DOI":"10.1080\/01480545.2021.1996594","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T06:42:31Z","timestamp":1636353751000},"page":"2833-2842","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Lead and lead\u2013arsenic combined exposure induces mortality and developmental impairments in zebrafish embryos: a study using wild-caught zebrafish from Bangladesh"],"prefix":"10.1080","volume":"45","author":[{"given":"Nusrat","family":"Jahan Toma","sequence":"first","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Anwar","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamanna","family":"Kabir","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Jakir","family":"Hosen","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2021,11,7]]},"reference":[{"key":"CIT0001","volume-title":"Toxicological profile for hexachlorobenzene","author":"ATSDR","year":"2013"},{"key":"CIT0002","volume-title":"Toxicological profile for arsenic","author":"ATSDR","year":"2007"},{"key":"CIT0003","volume-title":"Toxicological profile for arsenic","author":"ATSDR","year":"2000"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219336"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-016-0883-0"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1007\/s10311-018-0734-7"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.03.035"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-015-0267-x"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241610"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2003.12.010"},{"key":"CIT0011","unstructured":"Bangladesh Bureau of Statistics, 2015. Disability in Bangladesh: prevalence and pattern. In: Population monograph of Bangladesh. Ministry of Planning, Government of the People\u2019s Republic of Bangladesh. Available from: http:\/\/www.bbs.gov.bd"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.643972"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2011.02.006"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1177\/2333794X17696681"},{"key":"CIT0015","doi-asserted-by":"crossref","unstructured":"Biswas, S.J. et\u00a0al., 2021. Primary concept of arsenic toxicity: an overview. In: P. P. Adhikary, eds. Geostatistics and geospatial technologies for groundwater resources in India. Cham, Switzerland: Springer Nature, 323\u2013341.","DOI":"10.1007\/978-3-030-62397-5_16"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1080\/10937404.2018.1562391"},{"issue":"4","key":"CIT0017","first-page":"462","volume":"128","author":"Choudhury H.","year":"2008","journal-title":"Indian Journal of Medical Research"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2007.07.032"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1097\/01.NAJ.0000337736.76730.66"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-200201000-00006"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1002\/etc.2406"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1007\/BF01055567"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2011.07.106"},{"key":"CIT0024","doi-asserted-by":"crossref","unstructured":"El Ati-Hellal, M. and Hellal, F., 2021. Heavy metals in the environment and health impact. Available from:","DOI":"10.5772\/intechopen.97204"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2006.12.021"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2017.11.008"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508006806"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfi110"},{"issue":"1","key":"CIT0031","first-page":"00376","volume":"10","author":"Hossain A.","year":"2018","journal-title":"MOJ Orthopedics & Rheumatology"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1038\/nature12111"},{"issue":"1","key":"CIT0033","first-page":"1","volume":"2","author":"Jaishankar M.","year":"2014","journal-title":"Journal of Environment Pollution and Human Health"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2018.05.004"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-008-9284-4"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2019.12.009"},{"key":"CIT0037","unstructured":"Kataba, A., 2021. Studies on toxicological effects of lead in animals for evaluation of worldwide environmental lead pollution. Doctoral dissertation. Graduate School of Veterinary Medicine, Hokkaido University."},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.12717\/DR.2015.19.4.167"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2008.11.007"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1002\/path.2102"},{"key":"CIT0042","first-page":"29","volume":"26","author":"Lugowska K.","year":"2000","journal-title":"Piscaria"},{"key":"CIT1002","doi-asserted-by":"crossref","unstructured":"Mitra, A. K., et al. 2009. Lead poisoning: an alarming public health problem in Bangladesh. International Journal of Environmental Research and Public Health, 6 (1), 84\u201395.","DOI":"10.3390\/ijerph6010084"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1007\/s10311-010-0297-8"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9785"},{"issue":"6","key":"CIT0045","first-page":"327","volume":"3","author":"Nelson L.M.","year":"1995","journal-title":"Clinical Neuroscience"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2017.12.044"},{"issue":"10","key":"CIT0047","first-page":"RA329","volume":"11","author":"Papanikolaou N.C.","year":"2005","journal-title":"Medical Science Monitor"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph6020643"},{"issue":"1","key":"CIT0049","first-page":"2","volume":"11","author":"Patrick L.","year":"2006","journal-title":"Alternative Medicine Review"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-017-2061-3"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq266"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.41041"},{"key":"CIT0053","doi-asserted-by":"crossref","unstructured":"Roper, C. and Tanguay, R. L., 2018. Zebrafish as a model for developmental biology and toxicology. In: Handbook of developmental neurotoxicology. Academic Press, 143\u2013151. Available from:","DOI":"10.1016\/B978-0-12-809405-1.00012-2"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2014.10.026"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-018-0183-2"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1089\/zeb.2017.1447"},{"key":"CIT0057","unstructured":"S\u0142ominska, I. (1998). Sensitivity of early developmental stages of common carp (Cyprinus carpio L.) to lead and copper toxicity. Doctoral dissertation, Ph.D. thesis. Institute of Inland Fisheries, Olsztyn, 104 (in Polish)."},{"key":"CIT1001","doi-asserted-by":"crossref","unstructured":"Stackelberg, K., et al. 2015) Exposure to mixtures of metals and neurodevelopmental outcomes: a multidisciplinary review using an adverse outcome pathway framework. Risk Analysis, 35 (6), 971\u20131016.","DOI":"10.1111\/risa.12425"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1080\/15287390903337100"},{"key":"CIT0059","doi-asserted-by":"crossref","unstructured":"Tchounwou, P. B. et\u00a0al., 2012. Heavy metal toxicity and the environment. In: Molecular, clinical and environmental toxicology. Basel: Springer, 133\u2013164.","DOI":"10.1007\/978-3-7643-8340-4_6"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22673"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.123389"},{"key":"CIT0062","unstructured":"UNB, 2020. Lead exposure: Bangladesh 4th worst-hit in terms of affected children. The Daily Star. 20 July. Available from: https:\/\/www.thedailystar.net\/country\/news\/lead-exposure-bangladesh-4th-worst-hit-terms-affected-children-1938673"},{"key":"CIT0063","unstructured":"World Health Organization, 2018. Arsenic. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/arsenic"},{"key":"CIT0064","doi-asserted-by":"crossref","unstructured":"Weis, P. and Weis, J.S., 2020. The developmental toxicity of metals and metalloids in fish. In: M.C. Newman, A.W. McIntosh, Metal ecotoxicology. Boca Raton, FL: CRC Press, 145\u2013169.","DOI":"10.1201\/9781003069973-6"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/21.2.459"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(75)90030-5"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1007\/s10653-018-0114-z"},{"key":"CIT0068","first-page":"662","volume":"43","author":"Zhang X.J.","year":"2012","journal-title":"Acta Anatomica Sinica"}],"container-title":["Drug and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/01480545.2021.1996594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T13:17:02Z","timestamp":1666099022000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/01480545.2021.1996594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,7]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11,2]]}},"alternative-id":["10.1080\/01480545.2021.1996594"],"URL":"https:\/\/doi.org\/10.1080\/01480545.2021.1996594","relation":{},"ISSN":["0148-0545","1525-6014"],"issn-type":[{"value":"0148-0545","type":"print"},{"value":"1525-6014","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,7]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idct20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idct20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}