{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:02:27Z","timestamp":1740128547432,"version":"3.37.3"},"reference-count":41,"publisher":"Informa UK Limited","issue":"5","funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81873218","82074301"],"award-info":[{"award-number":["81873218","82074301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Project of Guangdong Province","award":["2021A0505030060","2020A0505090009"],"award-info":[{"award-number":["2021A0505030060","2020A0505090009"]}]},{"name":"Chinese Medicine Cooperation Special Program of the National Administration of Traditional Chinese Medicine","award":["GZYYGJ2021"],"award-info":[{"award-number":["GZYYGJ2021"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug and Chemical Toxicology"],"published-print":{"date-parts":[[2023,9,3]]},"DOI":"10.1080\/01480545.2022.2116645","type":"journal-article","created":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T05:00:46Z","timestamp":1661835646000},"page":"995-1003","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Acute and subacute oral toxicity of artemisinin-hydroxychloroquine sulfate tablets in beagle dogs"],"prefix":"10.1080","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0862-8444","authenticated-orcid":false,"given":"Xiaobo","family":"Li","sequence":"first","affiliation":[{"name":"Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China"},{"name":"Sci-tech Industrial Park, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjia","family":"Feng","sequence":"additional","affiliation":[{"name":"Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueming","family":"Yuan","sequence":"additional","affiliation":[{"name":"Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China"},{"name":"Sci-tech Industrial Park, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouya","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sci-tech Industrial Park, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Xu","sequence":"additional","affiliation":[{"name":"Sci-tech Industrial Park, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Xu","sequence":"additional","affiliation":[{"name":"Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China"},{"name":"The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3839-8769","authenticated-orcid":false,"given":"Jianping","family":"Song","sequence":"additional","affiliation":[{"name":"Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China"},{"name":"The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-3168","authenticated-orcid":false,"given":"Li","family":"Ru","sequence":"additional","affiliation":[{"name":"Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China"},{"name":"Sci-tech Industrial Park, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Sci-tech Industrial Park, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanting","family":"Wu","sequence":"additional","affiliation":[{"name":"Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China"},{"name":"The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv018"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.104228"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-010-8243-x"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.1782"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2016638"},{"key":"CIT3739105","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2019-0270"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00522"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0888-2"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.07.030"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2020.1817479"},{"key":"CIT9546852","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.12.4380"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.3109\/10408441003610571"},{"key":"CIT8302924","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613033"},{"key":"CIT0011","unstructured":"European Medicines Agency (EMA). 2010. Guideline on repeated dose toxicity."},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa216"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170316115938"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0111-8"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244778"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.106216"},{"key":"CIT0018","first-page":"6830459","volume":"2021","author":"Li X","year":"2021","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2010.09.005"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2022.105114"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2019.104486"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-020-0156-0"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02279-12"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1159\/000252658"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025619"},{"issue":"4","key":"CIT0026","first-page":"taz030","volume":"26","author":"Muller O.","year":"2019","journal-title":"Journal of Travel Medicine."},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1993"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.106212"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-018-6126-x"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06018-6"},{"key":"CIT1315083","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.02.003"},{"key":"CIT0031","unstructured":"The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH). 2009. Guidance on nonclinical safety studies for the conduct of human clinical trials and marketing authorization for pharmaceuticals."},{"key":"CIT0032","unstructured":"United States Food and Drug Administration (FDA). 1996. Guidance for industry: single dose acute toxicity testing for pharmaceuticals."},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30391-3"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104810"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.58631"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-018-0259-3"},{"key":"CIT0037","unstructured":"World Health Organization. 2021. World malaria report 2021."},{"issue":"6","key":"CIT0038","first-page":"75","volume":"22","author":"Zhang J.","year":"2005","journal-title":"Journal of Hebei North University"}],"container-title":["Drug and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/01480545.2022.2116645","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T10:37:58Z","timestamp":1691491078000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/01480545.2022.2116645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9,3]]}},"alternative-id":["10.1080\/01480545.2022.2116645"],"URL":"https:\/\/doi.org\/10.1080\/01480545.2022.2116645","relation":{},"ISSN":["0148-0545","1525-6014"],"issn-type":[{"type":"print","value":"0148-0545"},{"type":"electronic","value":"1525-6014"}],"subject":[],"published":{"date-parts":[[2022,8,29]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idct20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idct20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}