{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:24:39Z","timestamp":1772774679595,"version":"3.50.1"},"reference-count":54,"publisher":"Informa UK Limited","issue":"2","funder":[{"name":"Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah","award":["160\u2013140-1443"],"award-info":[{"award-number":["160\u2013140-1443"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug and Chemical Toxicology"],"published-print":{"date-parts":[[2025,3,4]]},"DOI":"10.1080\/01480545.2024.2369587","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T06:55:03Z","timestamp":1719557703000},"page":"294-302","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["Untargeted metabolic profiling of high-dose methotrexate toxicity shows alteration in betaine metabolism"],"prefix":"10.1080","volume":"48","author":[{"given":"Shahid","family":"Karim","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, King Abdulaziz University","place":["Jeddah, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huda","family":"Alkreathy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, King Abdulaziz University","place":["Jeddah, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Imran","family":"Khan","sequence":"additional","affiliation":[{"name":"Research Center, King Faisal Specialist Hospital and Research Center","place":["Jeddah, Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3281670"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15060674"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8641026"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-020-10042-3"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000513545"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6992"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.06.024"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh610"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14779072.2016.1239528"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.095"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.3615"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2020.11521"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2019.1656530"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08213-2"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.05.19"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511279"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200262040-00005"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/37.5.502"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.08.009"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.21608\/jmh.2020.35314.1078"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/859383"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1457-z"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.17632\/38rfykj6bp.2"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-014-1774-3"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031919"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20278"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.03.009"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3596-7"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo2020366"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.5149"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-017-0148-3"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704763"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23935"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.33552\/ACCS.2020.02.000549"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.72350"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2231"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.2005.25.9.1271"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.232"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1847159"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.014906"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00694"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.02.003"},{"issue":"3","key":"e_1_3_5_44_1","first-page":"344","article-title":"Effect of a short-term fast on ketamine-xylazine anesthesia in rats","volume":"50","author":"Struck M. B.","year":"2011","unstructured":"Struck, M. B., Andrutis, K. A., Ramirez, H. E., & Battles, A. H. (2011). Effect of a short-term fast on ketamine-xylazine anesthesia in rats. Journal of the American Association for Laboratory Animal Science: JAALAS, 50(3), 344\u2013348.","journal-title":"Journal of the American Association for Laboratory Animal Science: JAALAS"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22094"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000024579"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-021-01132-5"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123824"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00277"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9088-4"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-018-0549-0"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086135"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23811"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibror.2020.08.004"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.551758"}],"container-title":["Drug and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/01480545.2024.2369587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T06:49:47Z","timestamp":1740379787000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/01480545.2024.2369587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,27]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3,4]]}},"alternative-id":["10.1080\/01480545.2024.2369587"],"URL":"https:\/\/doi.org\/10.1080\/01480545.2024.2369587","relation":{},"ISSN":["0148-0545","1525-6014"],"issn-type":[{"value":"0148-0545","type":"print"},{"value":"1525-6014","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,27]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idct20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idct20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}