{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:37:13Z","timestamp":1792255033041,"version":"4.4.0"},"reference-count":37,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug and Chemical Toxicology"],"published-print":{"date-parts":[[2025,1,2]]},"DOI":"10.1080\/01480545.2024.2425994","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T21:50:24Z","timestamp":1732744224000},"page":"210-218","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Cannabidiol mitigates methotrexate-induced hepatic injury via SIRT-1\/p53 signaling and mitochondrial pathways: reduces oxidative stress and inflammation"],"prefix":"10.1080","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3739-9580","authenticated-orcid":false,"given":"Ilter","family":"Ilhan","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Suleyman Demirel University","place":["Isparta, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1545-035X","authenticated-orcid":false,"given":"Halil","family":"Asci","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Suleyman Demirel University","place":["Isparta, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-8786","authenticated-orcid":false,"given":"Ibrahim Ayd\u0131n","family":"Candan","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Alanya Alaaddin Keykubat University","place":["Antalya, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7933-0453","authenticated-orcid":false,"given":"Mehtap","family":"Savran","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Suleyman Demirel University","place":["Isparta, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3850-0137","authenticated-orcid":false,"given":"Orhan Berk","family":"Imeci","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Suleyman Demirel University","place":["Isparta, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3875-9365","authenticated-orcid":false,"given":"Mehmet Abdulkadir","family":"Sevuk","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Suleyman Demirel University","place":["Isparta, Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i29.10158"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016100"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-021-02774-3"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000534610"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.11.015"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.08.008"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.152840"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10111575"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/can.2016.0034"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2781"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.654340"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-023-08286-8"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms161125942"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.115374"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113752"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200790147"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0773-6"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.133"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.02.021"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2023.01.018"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2021.1982623"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.953078"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.07.033"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327119860188"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1556\/2060.104.2017.2.5"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8205983"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13114142"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02836-4"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2016.2318"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02497-3"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/can.2023.0153"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-102108-134850"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.114196"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-022-00559-7"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37157"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.4149\/bll_2017_042"}],"container-title":["Drug and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/01480545.2024.2425994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T06:36:44Z","timestamp":1738823804000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/01480545.2024.2425994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,2]]}},"alternative-id":["10.1080\/01480545.2024.2425994"],"URL":"https:\/\/doi.org\/10.1080\/01480545.2024.2425994","relation":{},"ISSN":["0148-0545","1525-6014"],"issn-type":[{"value":"0148-0545","type":"print"},{"value":"1525-6014","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idct20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idct20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-22","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}