{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:23:02Z","timestamp":1792120982767,"version":"4.4.0"},"reference-count":32,"publisher":"Informa UK Limited","issue":"6","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100032526","name":"Vectura Fertin Pharma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100032526","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug and Chemical Toxicology"],"published-print":{"date-parts":[[2025,11,2]]},"DOI":"10.1080\/01480545.2025.2491544","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T22:38:48Z","timestamp":1747175928000},"page":"1447-1460","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":6,"title":["A 13-week oral toxicity and toxicokinetic study of cannabidiol in Sprague Dawley rats with a 4-week recovery period"],"prefix":"10.1080","volume":"48","author":[{"given":"Wenhao","family":"Xia","sequence":"first","affiliation":[{"name":"Vectura Fertin Pharma Laboratories","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rendy","family":"Yanuar","sequence":"additional","affiliation":[{"name":"Vectura Fertin Pharma Laboratories","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Mandal","sequence":"additional","affiliation":[{"name":"Vectura Fertin Pharma Laboratories","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Renggli","sequence":"additional","affiliation":[{"name":"Vectura Fertin Pharma","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Ho","sequence":"additional","affiliation":[{"name":"Vectura Fertin Pharma Laboratories","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blaine","family":"Phillips","sequence":"additional","affiliation":[{"name":"Vectura Fertin Pharma Laboratories","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte Nykjaer","family":"Nikolajsen","sequence":"additional","affiliation":[{"name":"Fertin Pharma","place":["Vejle, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne Skov","family":"Jensen","sequence":"additional","affiliation":[{"name":"Fertin Pharma","place":["Vejle, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi Ziegler","family":"Bruun","sequence":"additional","affiliation":[{"name":"Fertin Pharma","place":["Vejle, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hoeng","sequence":"additional","affiliation":[{"name":"Vectura Fertin Pharma","place":["Basel, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0278-6915(98)00066-0"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241210273"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/can.2021.0156"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1293\/tox.31.1S"},{"key":"e_1_3_5_6_1","unstructured":"Center for Drug Evaluation and Research. (2018). Epidiolex non-clinical review. Application Number 210365Orig1s000. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2018\/210365Orig1s000PharmR.pdf"},{"key":"e_1_3_5_7_1","unstructured":"Charles River Laboratories. (2012). Technical Sheet: CD\u00ae rat hematology and biochemistry Jan 2006\u2013Dec 2011. https:\/\/azupcriversitestorage01.blob.core.windows.net\/storage-account-container\/Technical%20Resources\/Clinical%20Pathology%20Data%20for%20North%20American%20CD%20Rat%20Colonies%20for%20January%202006%20-%20December%202011.pdf"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611618"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714631"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005254"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2020.02.014"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623310374332"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.113799"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/can.2020.0093"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312448935"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.113778"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10030586"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186740"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(93)90005-j"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-9-59"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623310373778"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8143582"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-024-00643-0"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.42.491"},{"key":"e_1_3_5_25_1","unstructured":"National Advisory Committee for Laboratory Animal Research (NACLAR). (2022). Guidelines on the care and use of animals for scientific purposes. https:\/\/www.nparks.gov.sg\/-\/media\/naclar-guidelines-(second-edition)_v2.pdf"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.995"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2005.10.002"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/019262301301418847"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.114238"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.4607"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30136-3"},{"key":"e_1_3_5_32_1","unstructured":"United States Food and Drug Administration. (2021). Cannabis-derived products data acceleration plan. https:\/\/www.fda.gov\/media\/153183\/download?attachment"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623311406934"}],"container-title":["Drug and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/01480545.2025.2491544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T09:58:59Z","timestamp":1764237539000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/01480545.2025.2491544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11,2]]}},"alternative-id":["10.1080\/01480545.2025.2491544"],"URL":"https:\/\/doi.org\/10.1080\/01480545.2025.2491544","relation":{},"ISSN":["0148-0545","1525-6014"],"issn-type":[{"value":"0148-0545","type":"print"},{"value":"1525-6014","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,13]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idct20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idct20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-31","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}