{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:45:40Z","timestamp":1791812740821,"version":"4.3.4"},"reference-count":67,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug and Chemical Toxicology"],"DOI":"10.1080\/01480545.2026.2743943","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:53:40Z","timestamp":1791809620000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced reproductive toxicity following combined exposure to ethinylestradiol and levonorgestrel: evidence of non-additive endocrine disruption in male rats"],"prefix":"10.1080","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5497-2671","authenticated-orcid":false,"given":"Khaled","family":"Belhamzaoui","sequence":"first","affiliation":[{"name":"Pharmaceuticals Sciences Research Center (CRSP)","place":["Constantine, Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faouzi","family":"Dahdouh","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences, Higher School of Professors for Technological Education","place":["Skikda, Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed-R\u00e9da","family":"Djebbar","sequence":"additional","affiliation":[{"name":"Environmental Research Center (ERC), Alzone","place":["Annaba, Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houria","family":"Berrebbah","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Toxicology, Department of Biology, Faculty of Sciences, Badji-Mokhtar, Annaba University","place":["Annaba, Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salha Amira","family":"Benatallah","sequence":"additional","affiliation":[{"name":"Pharmaceuticals Sciences Research Center (CRSP)","place":["Constantine, Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houssem","family":"Chenna","sequence":"additional","affiliation":[{"name":"Pharmaceuticals Sciences Research Center (CRSP)","place":["Constantine, Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2016.12.010"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.1.1.6843"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17030746"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0076-6879(78)52032-6"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128x(95)00075-2"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-023-00495-6"},{"key":"e_1_3_6_8_1","unstructured":"Claiborne A. (1985). Catalase activity. In R. A. Greenwald (Ed.) CRC Handbook of Methods for Oxygen Radical Research (pp. 283\u2013284). CRC Press."},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2007.01.009"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2010.09.028"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn055"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1179\/2050854914Y.0000000023"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0048-9697(02)00342-x"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004200000163"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562872221105017"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0002"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86135-i"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1162015"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666201207104340"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqae032"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0039-128x(02)00073-9"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2015-1010"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-023-02703-7"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau-2025-480"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2010.02.002"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.18502\/ijrm.v23i1.18187"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2021.111332"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2014.01.006"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/es035342u"},{"key":"e_1_3_6_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2026.1699288"},{"key":"e_1_3_6_31_1","doi-asserted-by":"publisher","DOI":"10.12717\/DR.2025.29.3.63"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58125-0"},{"key":"e_1_3_6_33_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.070839"},{"key":"e_1_3_6_34_1","volume-title":"Manual of histologic staining methods of the Armed Forces Institute of Pathology","author":"Luna L. G.","year":"1968","unstructured":"Luna, L. G. (1968). Manual of histologic staining methods of the Armed Forces Institute of Pathology (3rd ed.). Blakiston Division, McGraw-Hill.","edition":"3"},{"key":"e_1_3_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2005.05.045"},{"key":"e_1_3_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10340-017-0894-4"},{"key":"e_1_3_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.02.012"},{"key":"e_1_3_6_38_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-24-0155"},{"key":"e_1_3_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21752"},{"key":"e_1_3_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(02)00946-2"},{"key":"e_1_3_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-038-0_7"},{"key":"e_1_3_6_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-12966-7_2"},{"key":"e_1_3_6_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiologyonline.2001.16.6.251"},{"key":"e_1_3_6_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312735"},{"key":"e_1_3_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.endmts.2021.100099"},{"key":"e_1_3_6_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10070512"},{"key":"e_1_3_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0166-445x(03)00177-2"},{"key":"e_1_3_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2010.08.002"},{"key":"e_1_3_6_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00299"},{"key":"e_1_3_6_50_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP378"},{"key":"e_1_3_6_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/21565562.2014.996025"},{"key":"e_1_3_6_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/w14060871"},{"key":"e_1_3_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-397175-3.00017-X"},{"key":"e_1_3_6_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-12323-5"},{"key":"e_1_3_6_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2010.64"},{"key":"e_1_3_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2015.02.004"},{"key":"e_1_3_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0166-445x(00)00090-4"},{"key":"e_1_3_6_58_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1010193"},{"key":"e_1_3_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2012.09.004"},{"key":"e_1_3_6_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02171503"},{"key":"e_1_3_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2019.08.009"},{"key":"e_1_3_6_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-023-01727-4"},{"key":"e_1_3_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2021.111215"},{"key":"e_1_3_6_64_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2009.0258"},{"key":"e_1_3_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(88)90084-5"},{"key":"e_1_3_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(79)92949-0"},{"key":"e_1_3_6_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.05.029"},{"key":"e_1_3_6_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17070913"}],"container-title":["Drug and Chemical Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/01480545.2026.2743943","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/01480545.2026.2743943","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/01480545.2026.2743943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:53:42Z","timestamp":1791809622000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/01480545.2026.2743943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":67,"alternative-id":["10.1080\/01480545.2026.2743943"],"URL":"https:\/\/doi.org\/10.1080\/01480545.2026.2743943","relation":{},"ISSN":["0148-0545","1525-6014"],"issn-type":[{"value":"0148-0545","type":"print"},{"value":"1525-6014","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idct20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idct20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}