{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:29:53Z","timestamp":1776986993220,"version":"3.51.4"},"reference-count":18,"publisher":"Informa UK Limited","issue":"4","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"2019 Wuhan Medical Scientific Research Program","award":["WX19D01"],"award-info":[{"award-number":["WX19D01"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Neurological Research"],"published-print":{"date-parts":[[2021,4,3]]},"DOI":"10.1080\/01616412.2020.1853989","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T11:11:22Z","timestamp":1607080282000},"page":"307-313","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":13,"title":["The intervention mechanism of emodin on TLR3 pathway in the process of central nervous system injury caused by herpes virus infection"],"prefix":"10.1080","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8019-4997","authenticated-orcid":false,"given":"Yongqian","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurology, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlian","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xijia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yantian Hospital of Southern University of Science and Technology, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.03.010"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1848"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.01.003"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2012.11.001"},{"key":"cit0005","first-page":"2","volume":"16","author":"Li M","year":"2017","journal-title":"Curr Neuropharmacol"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1863"},{"key":"cit0007","unstructured":"Ryota S, Akihisa K, Takahiko C, et al. Combating herpesvirus encephalitis by potentiating a tlr3\u2013mtorc2 axis. Nat Immunol. 2018."},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2009.09.013"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5631"},{"key":"cit0010","unstructured":"Yan D, Jie, X, Liang-Bin C, et al. Effect of emodin on coxsackievirus b3m-mediated encephalitis in hand, foot, and mouth disease by inhibiting toll-like receptor 3 pathway in vitro and in vivo. J Infect Dis. 2020."},{"issue":"2","key":"cit0011","first-page":"115","volume":"25","author":"Zhang CH","year":"2010","journal-title":"Chin J Ctrl Endem Dis"},{"issue":"9","key":"cit0012","first-page":"1069","volume":"9","author":"Huang JH","year":"2004","journal-title":"Chin J Clin Pharmacol Ther"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061677"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25642"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.11.069"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020053"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1038\/nm1140"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1038\/nm1204-1294"}],"container-title":["Neurological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/01616412.2020.1853989","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T10:04:56Z","timestamp":1651831496000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/01616412.2020.1853989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,4]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,3]]}},"alternative-id":["10.1080\/01616412.2020.1853989"],"URL":"https:\/\/doi.org\/10.1080\/01616412.2020.1853989","relation":{},"ISSN":["0161-6412","1743-1328"],"issn-type":[{"value":"0161-6412","type":"print"},{"value":"1743-1328","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,4]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=yner20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=yner20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}