{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:36:34Z","timestamp":1777894594492,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p>\n                    The objective of this study was to characterize the renal toxicity and carcinogenicity of p-nitrobenzoi c acid in F344 rats. Dose levels in 13-week and 2-year studies ranged from 630\u201410,000 ppm and 1,250\u20145,000 ppm, respectively. At 13 weeks, renal lesions included minimal to mild hyaline droplet accumulation in male rats and karyomegaly in male and female rats. At 2 years, renal lesions included proximal tubule epithelial cell hyperplasia in male rats and oncocytic hyperplasia in high-dose male and female rats, and a decreased severity of nephropathy in males and females. The hyaline droplets in renal tubular epithelial cells of male rats at 13 weeks were morphologically similar to those described in \u03b1\n                    <jats:sub>2u<\/jats:sub>\n                    -globulin nephropathy. Using immunohistochemica l methods, \u03b1\n                    <jats:sub>2u<\/jats:sub>\n                    -globulin accumulation was associated with the hyaline droplets. In addition, at 13 weeks, cell proliferation as detected by PCNA immunohistochemistry was signifi cantly increased in males exposed to 5,000 and 10,000 ppm when compared to controls. Cytotoxicity associated with \u03b1\n                    <jats:sub>2u<\/jats:sub>\n                    -globulin nephropathy such as single-cell necrosis of the P2 segment epithelium or accumulation of granular casts in the outer medulla did not occur in the 13-week study. In addition, chronic treatment related nephrotoxic lesions attributed to accumulation of \u03b1\n                    <jats:sub>2u<\/jats:sub>\n                    -globulin such as linear foci of mineralization within the renal papilla, hyperplasia of the renal pelvis urothelium and kidney tumors were not observed. Although there was histologic evidence of \u03b1\n                    <jats:sub>2u<\/jats:sub>\n                    -globulin accumulation in male rats at 13 weeks, the minimal severity of nephropathy suggests that the degree of cytotoxicity was below the threshold, which would contribute to the development of renal tumors at 2 years.\n                  <\/jats:p>","DOI":"10.1080\/019262301317226302","type":"journal-article","created":{"date-parts":[[2003,1,29]],"date-time":"2003-01-29T23:23:13Z","timestamp":1043882593000},"page":"507-513","source":"Crossref","is-referenced-by-count":11,"title":["p-Nitrobenzoic Acid \u03b12u Nephropathy in 13-week Studies is not Associated with Renal Carcinogenesis in 2-year Feed Studies"],"prefix":"10.1177","volume":"29","author":[{"given":"Kyha D.","family":"Williams","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, 27606, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June","family":"Dunnick","sequence":"additional","affiliation":[{"name":"Environmental Toxicology Program, National Institutes of Environmental Health Sciences, PO Box 12233, Research Triangle Park, North Carolina 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Horton","sequence":"additional","affiliation":[{"name":"Environmental Toxicology Program, National Institutes of Environmental Health Sciences, PO Box 12233, Research Triangle Park, North Carolina 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold","family":"Greenwell","sequence":"additional","affiliation":[{"name":"Environmental Toxicology Program, National Institutes of Environmental Health Sciences, PO Box 12233, Research Triangle Park, North Carolina 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra R.","family":"Eldridge","sequence":"additional","affiliation":[{"name":"Pathology Associates International, 15 Woman's Mill Ct, Frederick, Maryland 21701, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Elwell","sequence":"additional","affiliation":[{"name":"Pfizer, Inc., Global Research and Development, MS 8274-31, Eastern Point Road, Groton, Connecticut 06340, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Sills","sequence":"additional","affiliation":[{"name":"Environmental Toxicology Program, National Institutes of Environmental Health Sciences, PO Box 12233, Research Triangle Park, North Carolina 27709, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,8,1]]},"reference":[{"key":"atypb1","unstructured":"Boorman GA, Eustis SL (1986). The pathology working group as a means for assuring pathology quality in toxicological studies. In: Managing Conduct and Data Quality of Toxicologic Studies, Hoover BK, Baldwin JK, Uelner AF, Whitmire CE, Davis CL, Bristol DW (eds). Princeton Scientifi c Publishing, Princeton, New Jersey , pp 271\u2014275."},{"key":"atypb2","first-page":"1","volume":"13","author":"Borghoff S.","year":"1993","journal-title":"CIIT Activities"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(91)90205-S"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1177\/37.6.2470808"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.2307\/3433861"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(90)90120-B"},{"key":"atypb7","first-page":"3512","volume":"51","author":"Dietrich DR","year":"1991","journal-title":"Cancer Res"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(91)90244-9"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.2307\/3431870"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.93101s5199"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(91)90149-C"},{"key":"atypb12","first-page":"313","volume":"99","author":"Hard GC","year":"1993","journal-title":"Environ Health Perspect"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.3109\/10408449409021607"},{"key":"atypb14","unstructured":"Hardisty JF, Boorman GA (1986). National Toxicology Program pathology quality assurance procedures. In: Managing Conduct and Data Quality of Toxicologic Studies, Hoover BK, Baldwin JK, Uelner AF , Whitmire CE, Davis CL, Bristol DW (eds). Princeton Scientifi c Publishing, Princeton, New Jersey , pp 263\u2014269."},{"key":"atypb15","volume-title":"Bioassay of lindane for possible carcinogenecity (CAS No 58-89-9). (NCI Carcinogenesis Technical Report No 14)","author":"National Cancer Institute (NCI)","year":"1977"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(92)90296-5"},{"key":"atypb17","volume-title":"Toxicology and carcinogenesis studies of p-nitrobenzoic acid (CAS No. 62-23-7) in F344\/N Rats and B6C3F1 mice (feed studies), NTP Technical Report No 442","author":"National Toxicology Program (NTP)","year":"1994"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(76)80743-0"},{"key":"atypb19","first-page":"564","volume":"57","author":"Short B.","year":"1987","journal-title":"Lab Invest"},{"key":"atypb20","unstructured":"Swenberg JA, Lehman-McKeeman LD (1999). \u03b12u-globulin-associated nephropathy as a mechanism of renal tubule cell carcinogenesis in male rats. In: Species differences in thyroid, kidney, and urinary bladder carcinogenesis , Capen CC, Dybing E, Rice JM, Wilbourn JB (eds). International Agency for Research on Cancer, Lyon, France, pp 95\u2014118."},{"key":"atypb21","volume-title":"\u03b12u-Globulin: Association with chemically induced renal toxicity and neoplasia in the male rat. (EPA\/625\/3-91\/019F)","author":"United States Environmental Protection Agency (USEPA)","year":"1991"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/019262301317226302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/019262301317226302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:26:06Z","timestamp":1777620366000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1080\/019262301317226302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1080\/019262301317226302"],"URL":"https:\/\/doi.org\/10.1080\/019262301317226302","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}