{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:23:32Z","timestamp":1792427012177,"version":"4.5.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p>Neuropathological lesions found in chronic human Minamata disease tend to be localized in the calcarine cortex of occipital lobes, the pre- and postcentral lobuli, and the temporal gyri. The mechanism for the selective vulnerability is still not clear, though several hypotheses have been proposed. One hypothesi s is vascular and postulates that the lesions are the result of ischemia secondary to compression of sulcal arteries from methylmercury-induced cerebral edema. To test this hypothesis, we studied common marmosets because the cerebrum of marmosets has 2 distinct deep sulci, the calcarine and Sylvian fi ssures. MRI analysis, mercury assays of tissue specimens, histologic and histochemical studies of the brain are reported and discussed. Brains sacrifi ced early after exposure to methylmercury showed high contents of methylmercury and edema of the cerebral white matter. These results may explain the selective cortical degeneration along the deep cerebral fi ssures or sulci.<\/jats:p>","DOI":"10.1080\/019262301317226375","type":"journal-article","created":{"date-parts":[[2003,1,29]],"date-time":"2003-01-29T23:23:13Z","timestamp":1043882593000},"page":"565-573","source":"Crossref","is-referenced-by-count":40,"title":["Methylmercury Poisoning in Common Marmosets\u2014A Study of Selective Vulnerability Within the Cerebral Cortex"],"prefix":"10.1177","volume":"29","author":[{"given":"Komyo","family":"Eto","sequence":"first","affiliation":[{"name":"National Institute for Minamata Disease, Minamatu City, Kumamoto, Japan, ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yasutake","sequence":"additional","affiliation":[{"name":"National Institute for Minamata Disease, Minamatu City, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kuwana","sequence":"additional","affiliation":[{"name":"National Institute for Minamata Disease, Minamatu City, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukunori","family":"Korogi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kumamoto University School of Medicine, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Akima","sequence":"additional","affiliation":[{"name":"Department of Pathology, Toho University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshie","family":"Shimozeki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Toho University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Kumamoto University School of Medicine, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Technologists, Animal Care Co Ltd, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2001,8,1]]},"reference":[{"key":"atypb1","first-page":"637","volume":"13","author":"Ali SF","year":"1992","journal-title":"Neurotoxicol"},{"key":"atypb2","unstructured":"Cavanagh JB (1977). Metabolic mechanisms of neurotoxicity caused by mercury. In: Neurotoxicology, Vol.1, Roizin L, Shiraki H, Grcevic N (eds). Raven Press, New York, pp 283\u2014288."},{"key":"atypb3","unstructured":"Eto K., Takeuchi T. (1983). A comparative study of the neuropathological change between anoxia and methylmercury. In: Research Report on Minamata disease for 1982 (in Japanese). The Japan Public Health Association, Tokyo , pp 87\u201489."},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1080\/00028896009344108"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.3358\/shokueishi.27.528"},{"key":"atypb6","doi-asserted-by":"crossref","unstructured":"LeBel CP , Ali SF, McKee M., Bondy SC (1990). Organometal-induced in oxygen reactive species: the potential of 2', 7'-dichlorofluorescein diacetate as an index of neurotoxic damage. 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Proceedings, Assessment of Environmental Pollution and Health Effects from Methylmercury, 8\u20149 Oct. 1993, Asahi Publ Co, Minamata Japan, pp 210\u2014221."},{"key":"atypb18","unstructured":"Netter FH (1975). A compilation of paintings on the normal and pathologic anatomy of the nervous system with a supplement on the hypothalamus. In: The Ciba Collection of Medical illustrations. 1. CIBA (Commissioned and Published) CIBA Pharmaceutical Co., Division of CIBA-Geigy Corporation, Rochester, NY, pp 63."},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1267\/ahc.8.257"},{"key":"atypb20","first-page":"451","volume":"80","author":"Shaw Cheng-Mei","year":"1975","journal-title":"Am J Pathol"},{"key":"atypb21","unstructured":"Shaw Cheng-Mei, Mottet NK, Chen WJ ( 1980). Effects of methylmercury on the visual system of the rhesus macaque (Macaca mulatta). II. Neuropathological fi ndings (with emphasis on vascular lesions in the brain). In: Neurotoxicity of the Visual System, Merigan WH, Weiss B (eds). Raven Press, New York, pp 123\u2014134."},{"key":"atypb22","first-page":"57","volume":"1","author":"Shaw Cheng-Mei","year":"1979","journal-title":"Neurotoxicology"},{"key":"atypb23","unstructured":"Shiraki H., Nagashima K. (1997). Essential neuropathy of alkylmercury intoxications in humans from the acute to the chronic stage with special reference to experimental whole body autoradiographi c study using labeled mercury compounds. Neurotoxicology, Roizin L, Shiraki H, Grcevic N (eds). Raven Press, New York, pp 247\u2014260."},{"key":"atypb24","unstructured":"Shiraki H., Takeuchi T. (1971). Pathology of the nervous system. In: Minamata disease. 2nd ed. Minckler J (ed). McGraw-Hill, New York, pp 1651\u20141665."},{"key":"atypb25","unstructured":"Takeuchi T., Katsuragi S., Sano T. ( 1980). The pathogenesis of Minamata disease: A pathological study for the cause of localized damages of the cerebrum. 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