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In this study, we investigated immunohistochemically the association between expression of TGF- \u03b1 and cell proliferation activity in mouse hepatoblastoma s (HBs) and hepatocellular carcinomas (HCCs) induced in B6C3F1 mice by diethylnitrosamine and sodium phenobarbital. The TGF- \u03b1-positive rate in HBs (29.2%) was significantly higher than that in HCCs (12.7%). Likewise, the proliferating cell nuclear antigen-positive rate (22.2%) was higher than the HCC value (14.5%). On the individual data for both TGF- \u03b1 and PCNA, most of the HBs showed higher positive rates than HCCs. In HBs, TGF- \u03b1 was localized only in the nuclei, whereas some HCC cells stained positive both in their nuclei and cytoplasm (0.6%). These results suggest expression of TGF- \u03b1 and its localization might be linked to cell proliferation and play a role in malignant progression of mouse HBs.<\/jats:p>","DOI":"10.1080\/01926230152499962","type":"journal-article","created":{"date-parts":[[2003,1,29]],"date-time":"2003-01-29T23:23:13Z","timestamp":1043882593000},"page":"479-482","source":"Crossref","is-referenced-by-count":9,"title":["Greater Expression of Transforming Growth Factor \u03b1 and Proliferating Cell Nuclear Antigen Staining in Mouse Hepatoblastomas Than Hepatocellular Carcinomas Induced by a Diethylnitrosamine-Sodium Phenobarbital Regimen"],"prefix":"10.1177","volume":"29","author":[{"given":"Tetsuya","family":"Sakairi","sequence":"first","affiliation":[{"name":"Toxicology Laboratory, Research Center, Mitsubishi-Tokyo Pharmaceuticals, Inc., 100-5, Yana, Kisarazu, Chiba 292-0812, Japan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Toxicology Laboratory, Research Center, Mitsubishi-Tokyo Pharmaceuticals, Inc., 100-5, Yana, Kisarazu, Chiba 292-0812, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Goto","sequence":"additional","affiliation":[{"name":"Toxicology Laboratory, Research Center, Mitsubishi-Tokyo Pharmaceuticals, Inc., 100-5, Yana, Kisarazu, Chiba 292-0812, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyoko","family":"Okada","sequence":"additional","affiliation":[{"name":"Toxicology Laboratory, Research Center, Mitsubishi-Tokyo Pharmaceuticals, Inc., 100-5, Yana, Kisarazu, Chiba 292-0812, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manami","family":"Kusakabe","sequence":"additional","affiliation":[{"name":"Toxicology Laboratory, Research Center, Mitsubishi-Tokyo Pharmaceuticals, Inc., 100-5, Yana, Kisarazu, Chiba 292-0812, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Toxicology Laboratory, Research Center, Mitsubishi-Tokyo Pharmaceuticals, Inc., 100-5, Yana, Kisarazu, Chiba 292-0812, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Toxicology Laboratory, Research Center, Mitsubishi-Tokyo Pharmaceuticals, Inc., 100-5, Yana, Kisarazu, Chiba 292-0812, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Sano","sequence":"additional","affiliation":[{"name":"Toxicology Laboratory, Research Center, Mitsubishi-Tokyo Pharmaceuticals, Inc., 100-5, Yana, Kisarazu, Chiba 292-0812, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Mutai","sequence":"additional","affiliation":[{"name":"Toxicology Laboratory, Research Center, Mitsubishi-Tokyo Pharmaceuticals, Inc., 100-5, Yana, Kisarazu, Chiba 292-0812, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,6,1]]},"reference":[{"key":"atypb1","first-page":"E256","volume":"259","author":"Brown PI","year":"1990","journal-title":"Am J Physiol"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)03884-Y"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(88)80001-1"},{"key":"atypb4","first-page":"707","volume":"47","author":"Derynck R.","year":"1987","journal-title":"Cancer Res"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)90154-X"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/10.7.1345"},{"key":"atypb7","unstructured":"Diwan BA, Ward JM, Rice JM ( 1992). 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