{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:36:51Z","timestamp":1777894611261,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2001,10,1]],"date-time":"2001-10-01T00:00:00Z","timestamp":1001894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:p>Japanese medaka ( Oryzias latipes) were continually exposed in a flow-through diluter system for 9 months to measured bromodichloromethan e (BDCM) concentrations of 0.018, 0.143, or 1.424 mg\/L. Parameters evaluated were hepatocarcinogenicity, hepatocellular proliferation, hematology, and intrahepatic BDCM concentration. BDCM was not hepatocarcinogeni c to medaka at the concentrations tested. Chronic toxicity was evidenced at 6 and 9 months by statistically significant ( \u03b1 =0.05) levels of gallbladder lesions and bile duct abnormalities in medaka treated with 1.424 mg\/L BDCM. Hepatocellular proliferation was assessed after 1, 4, and 20 days of BDCM exposure. Treatment-related increases or decreases in cellular proliferation were not observed at any time point. Hematocrit, leukocrit, cell viability, and cell counts of treated fish after 9 months of BDCM exposure were not significantly different from control fish. Intrahepatic concentrations were evaluated by gas chromatography after 9 months of BDCM exposure. Fish livers from all three BDCM treatments had detectable amounts of BDCM, with median intrahepatic concentrations of 1.02, 2.89, and 21.25 mg BDCM\/kg fish liver in the low, middle, and high concentrations, respectively. Medaka chronic toxicity effects of statistically significant gallbladder and bile duct abnormalities occurred at 1.424 mg\/L BDCM, well above median drinking water levels.<\/jats:p>","DOI":"10.1080\/019262301753385997","type":"journal-article","created":{"date-parts":[[2003,1,29]],"date-time":"2003-01-29T23:23:13Z","timestamp":1043882593000},"page":"662-669","source":"Crossref","is-referenced-by-count":5,"title":["Chronic Toxicity of Bromodichloromethane to the Japanese Medaka (Oryzias latipes)"],"prefix":"10.1177","volume":"29","author":[{"given":"Margaret W.","family":"Toussaint","sequence":"first","affiliation":[{"name":"GEO-CENTERS, Fort Detrick, Maryland, y.mil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan B.","family":"Rosencrance","sequence":"additional","affiliation":[{"name":"U.S. Army Center for Environmental Health Research, Fort Detrick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda M.","family":"Brennan","sequence":"additional","affiliation":[{"name":"GEO-CENTERS, Fort Detrick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Dennis","sequence":"additional","affiliation":[{"name":"GEO-CENTERS, Fort Detrick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph R.","family":"Beaman","sequence":"additional","affiliation":[{"name":"GEO-CENTERS, Fort Detrick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn J.","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Experimental Pathology Laboratory, Herndon, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence J.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"U.S. Army Center for Environmental Health Research, Fort Detrick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"JR","given":"Henry S.","family":"Gardner","sequence":"additional","affiliation":[{"name":"U.S. Army Center for Environmental Health Research, Fort Detrick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2001,10,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.99107s1207"},{"key":"atypb2","volume-title":"Occurrence Assessment for Disinfectants and Disinfection Byproducts in Public Drinking Water Supplies. 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