{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:23:32Z","timestamp":1792427012727,"version":"4.5.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>Common marmosets were used as model animals for methylmercury (MeHg) poisoning. Six marmosets were given MeHg of 5 ppm Hg in drinking water. The animals were divided into 3 groups of 2 each. The first group was examined for acute symptomatic MeHg poisoning. They were given MeHg for 70 and 90 days, respectively, to manifest severe symptoms. The second group was sacrificed after 38 days of MeHg exposure, when they had acute-subclinical MeHg poisoning. The third group of animals was exposed for 21 days, and then observed for 2.5 years without MeHg exposure. One of them showed typical symptoms of MeHg poisoning after MeHg exposure had ended, but the other one showed only slight symptoms without ataxia. This experiment demonstrated that MeHg causes pathological changes in neural tissues including the peripheral nerves in common marmosets. Furthermore, common marmosets were found to show MeHg-induced pathological changes similar to those in humans in the cerebrum and cerebellum.<\/jats:p>","DOI":"10.1080\/01926230290166814","type":"journal-article","created":{"date-parts":[[2003,1,6]],"date-time":"2003-01-06T23:28:16Z","timestamp":1041895696000},"page":"723-734","source":"Crossref","is-referenced-by-count":17,"title":["Methylmercury Poisoning in Common Marmosets\u2014MRI Findings and Peripheral Nerve Lesions"],"prefix":"10.1177","volume":"30","author":[{"given":"Komyo","family":"Eto","sequence":"first","affiliation":[{"name":"National Institute for Minamata Disease, Minamata City, Kumamoto, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yasutake","sequence":"additional","affiliation":[{"name":"National Institute for Minamata Disease, Minamata City, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukunori","family":"Korogi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kumamoto University School of Medicine, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Akima","sequence":"additional","affiliation":[{"name":"Department of Pathology, Toho University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshie","family":"Shimozeki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Toho University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Tokunaga","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Kumamoto University School of Medicine, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kuwana","sequence":"additional","affiliation":[{"name":"National Institute for Minamata Disease, Minamata City, Kumamoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Technologist, Animal Care Co Ltd, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,10,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1177\/019262339702500612"},{"key":"atypb2","first-page":"565","volume":"28","author":"Eto K.","year":"1978","journal-title":"Acta Pathol Jpn"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1080\/019262301317226375"},{"key":"atypb4","unstructured":"Grant CA (1973). Pathology of experimental methyl mercury intoxication: Some problems of exposure and response. In: Mercury, Mercurials and Mercaptane, Miller MW, Clarkson TW (eds). Charles C Thomas Publishers , Springfield, IL, pp 284\u2014312."},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.17.4.235"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.3358\/shokueishi.27.528"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880080210"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.37.3.333"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.3109\/01658109309044582"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00690688"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685320"},{"key":"atypb12","first-page":"13","volume":"23","author":"Ohkawa T.","year":"1977","journal-title":"J Hyg Chem"},{"key":"atypb13","unstructured":"Pentschew A. (1958). Quecksibervergiftung. Handbuch der Speziellen Pathologishen Anatomie und Histologie X III\/2, B, Springer-Verlag , Berlin, pp 2007\u20142024."},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.17.1.208"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1267\/ahc.8.257"},{"key":"atypb16","first-page":"451","volume":"80","author":"Shaw CM","year":"1975","journal-title":"Am J Pathol"},{"key":"atypb17","unstructured":"Shiraki H. (1979). Neuropathological aspects of organic mercury intoxication, including Minamata disease. In: Handbook of Clinical Neurology , Vol 36, Vinken PJ, Bruyn GW (eds). Elsevier, North-Holland, Amsterdam , pp 83\u2014145."},{"key":"atypb18","unstructured":"Shiraki H., Takeuchi T. (1971). Pathology of the nervous system. In: Minamata Disease, 2nd ed, Minckler J (ed). McGraw-Hill, New York, pp 1651\u20141665."},{"key":"atypb19","first-page":"113","volume":"10","author":"Suda I.","year":"1989","journal-title":"Neurotoxicology"},{"key":"atypb20","unstructured":"Takeuchi T. (1968). Pathology of Minamata disease. In: Minamata Disease, Kutsuna M (ed). Kumamoto University Study Group, Kumamoto , Japan, pp 141\u2014252."},{"key":"atypb21","unstructured":"Takeuchi T. (1977). Neuropathology of Minamata disease in Kumamoto, especially at the chronic stage. In: Neurotoxicology, Roizin L, Shiraki H, Grcevic N (eds). Raven Press, New York, pp 235\u2014246."},{"key":"atypb22","unstructured":"Takeuchi T., Eto K. (1975). Minamata disease. In: Studies on the Health Effects of Alkylmercury in Japan. Environment Agency, Tokyo, 28\u201462."},{"key":"atypb23","unstructured":"Takeuchi T., Eto K. (1977). Pathology and pathogenesis of Minamata disease . In: Minamata Disease: Methylmercury Poisoning in Minamata and Niigata, Japan, Tsubaki T, Irukayama K (eds). Kodansha, Tokyo, pp 103\u2014 141."},{"key":"atypb24","unstructured":"Takeuchi T., Eto K. (1986). Pathology of mild prolonged cases of Minamata disease. In: Recent Advances in Minamata Disease Studies: Methylmercury Poisoning inMinamata and Niigata, Japan, Tsubaki T, Takahashi H (eds). Kodansha, Tokyo, pp 117\u2014134."},{"key":"atypb25","unstructured":"Takeuchi T., Eto K. (1999). Peripheral nerves in Minamata disease. In: The Pathology of Minamata Disease\u2014A Tragic Story of Water Pollution. Nakayama H, Sumiyoshi A (editorial collaborations), Kyushu University Press, Inc, Fukuoka, Japan, pp 149\u2014174."},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.32.12.1369"},{"key":"atypb27","first-page":"379","volume":"34","author":"Tryphonas L.","year":"1973","journal-title":"Am J Vet Res"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1007\/BF01700983"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/01926230290166814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/01926230290166814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:27:46Z","timestamp":1777620466000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1080\/01926230290166814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["10.1080\/01926230290166814"],"URL":"https:\/\/doi.org\/10.1080\/01926230290166814","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}