{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:08:11Z","timestamp":1792130891107,"version":"4.4.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p>The incidence of thymic B cell lymphoid follicles was retrospectively studied in 62 male and 58 female healthy control beagle dogs (age 11.3 \u00b1 4.8, range 6 to 23 months). The animals were selected from toxicological studies performed in the period 1990\u20142001 at the Organon labs. The animals had received vehicle treatment. Thorough microscopic examination of the thymus in hematoxylin &amp; eosin (H&amp;E)-stained sections resulted in an unexpectedly high overall incidence of 70% of medullary lymphoid follicles. Occasionally, these lymphoid follicles contained germinal centers. With the use of a T- and B cell marker (respectively CD3 and CD79 \u03b1) we confirmed that the lymphoid follicles exclusively contained large numbers of B lymphocytes. Moreover, with the use of the B cell marker, almost all animals (97%) prove to have B cell rich medullary areas. The study also confirmed that the dog thymus underwent progressive involution during the period from 6 to 23 months of age. As a consequence of the involution, B cell areas and lymphoid follicles may be obscured in some H&amp;E sections. Results of this study indicated that dense B lymphocyte aggregates and\/or B lymphoid follicles are a normal constituent of the canine thymus.<\/jats:p>","DOI":"10.1080\/01926230390183706","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T10:01:38Z","timestamp":1217239298000},"page":"214-219","source":"Crossref","is-referenced-by-count":18,"title":["The Incidence of Thymic B Lymphoid Follicles in Healthy Beagle Dogs"],"prefix":"10.1177","volume":"31","author":[{"given":"Jan-Peter H. T. M.","family":"Ploemen","sequence":"first","affiliation":[{"name":"Department of Toxicology and Drug Disposition, NV Organon, Oss, The Netherlands,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma T.M.","family":"Ravesloot","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Drug Disposition, NV Organon, Oss, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Van Esch","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Drug Disposition, NV Organon, Oss, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2003,2,1]]},"reference":[{"key":"atypb1","volume-title":"Microscopic Anatomy of the Dog. A Photographic Atlas","author":"Adam SA","year":"1970"},{"key":"atypb2","unstructured":"Aster J., Kumar V. (1999). In: Robbins Pathologic Basis of Disease, Cotran RS, Kumar V, Collins T (eds). 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