{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:14:12Z","timestamp":1778602452537,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:p>Forty-one cases of histiocytic sarcoma (HS) in C57BL\/6J mice were histopathologically studied with special regard to unexpected associated hematopoietic disorders. These cases were retrieved among C57BL\/6J female mice used as control mice in a chronic low-dose irradiation experiment. Hematopoietic characteristics were analysed by comparison to 41 disease-free mice from the same cohort. Tumoral involvement of the liver was observed in all 41 HS-bearing mice, followed by infiltration of the spleen (61.8%), lung (32.4%), bone marrow (14.3%), uterus (12.2%), lymph node (9.8%), and kidney (2.4%). By comparative analysis, we were able to demonstrate a significant association of HS with liver hematopoiesis (89.5% in HS group vs 15% in control mice, p &lt; 0 .00001), and with central hematopoietic disorders involving the myelocytic cells (decreased in HS, p = 0 .003) and erythrocytic cells (increased in HS, p = 0 .001). Microscopic characteristics of these 41 cases and physiopathology of the newly described hematopoietic features in HS are further discussed.<\/jats:p>","DOI":"10.1080\/01926230390204342","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T10:01:38Z","timestamp":1217239298000},"page":"304-309","source":"Crossref","is-referenced-by-count":19,"title":["Histiocytic Sarcoma in C57BL\/6J Female Mice is Associated with Liver Hematopoiesis: Review of 41 Cases"],"prefix":"10.1177","volume":"31","author":[{"given":"Magali","family":"Lacroix-Triki","sequence":"first","affiliation":[{"name":"Laboratoire d'Histologie-Embryologie, Facult\u00e9 de M\u00e9decine Toulouse-Rangueil, 31062 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laetitia","family":"Lacoste-Collin","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique, CHU Rangueil, 31403 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Jozan","sequence":"additional","affiliation":[{"name":"Laboratoire d'Histologie-Embryologie, Facult\u00e9 de M\u00e9decine Toulouse-Rangueil, 31062 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"Charlet","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Epid\u00e9miologie, H\u00f4tel-Dieu, 31052 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Caratero","sequence":"additional","affiliation":[{"name":"Laboratoire d'Histologie-Embryologie, Facult\u00e9 de M\u00e9decine Toulouse-Rangueil, 31062 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Courtade","sequence":"additional","affiliation":[{"name":"Laboratoire d'Histologie-Embryologie, Facult\u00e9 de M\u00e9decine Toulouse-Rangueil, 31062 Toulouse, France, courtade@ cict.fr"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-74"},{"key":"atypb2","first-page":"802","volume":"108","author":"Barsoum NJ","year":"1984","journal-title":"Arch Pathol Lab Med"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1177\/019262339502300503"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1080\/09553000210151639"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.1988.Supplement_9.10"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1999.8782"},{"key":"atypb7","first-page":"E476","volume":"274","author":"Erben RG","year":"1998","journal-title":"Am J Physiol"},{"key":"atypb8","first-page":"295","volume":"106","author":"Freitas I.","year":"2001","journal-title":"J Anat Embryol"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-84110-1_8"},{"key":"atypb10","unstructured":"Frith CH, Ward JM, Harleman JH, Stromberg PC, Halm S., Inoue T., Wright JA (2001). 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