{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:39:14Z","timestamp":1777894754615,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p>\n                    Species and sex differences in susceptibility to vincristine sulphate (VCR)-induced olfactory epithelial lesions were investigated among the BALB\/c mice, Crj: CD(SD) IGS rats and common marmoset monkeys following a single intravenous administration on day 1. As dosage levels, the 0.17-fold LD\n                    <jats:sub>10<\/jats:sub>\n                    , 0.6-fold LD\n                    <jats:sub>10<\/jats:sub>\n                    and LD\n                    <jats:sub>10<\/jats:sub>\n                    were used for mice and rats, and a maximum tolerated dose (MTD) was chosen only for monkeys. The order of strength of VCR action on peripheral neuropathic signs, body weight gain, and hematological parameters was mice &gt; rats &gt; monkeys, without clear sex differences. Histopathologically, on day 2, single cell death in the olfactory epithelium and vomeronasal organ was observed only in male mice at LD\n                    <jats:sub>10<\/jats:sub>\n                    , and in female mice at 0.6-fold LD\n                    <jats:sub>10<\/jats:sub>\n                    or more. On day 5, the olfactory epithelium in these mice showed regenerative proliferation suggesting a sign of recovery. On day 10, axonopathy and demyelination in the sciatic and trigeminal nerves were noted in mice of both sexes at 0.6-fold LD\n                    <jats:sub>10<\/jats:sub>\n                    or more. In rats and monkeys of either sex, however, no morphological changes were observed at any dose level. In conclusion, mice, particularly females, were shown to be more susceptible to VCR-induced apoptosis in the olfactory epithelium than rats and monkeys.\n                  <\/jats:p>","DOI":"10.1080\/01926230600695557","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T16:18:41Z","timestamp":1147450721000},"page":"223-231","source":"Crossref","is-referenced-by-count":15,"title":["Species and Sex Differences in Susceptibility to Olfactory Lesions Among the Mouse, Rat and Monkey Following an Intravenous Injection of Vincristine Sulphate"],"prefix":"10.1177","volume":"34","author":[{"given":"Kiyonori","family":"Kai","sequence":"first","affiliation":[{"name":"Drug Safety Research Laboratory, Daiichi Pharmaceutical Company Ltd., Tokyo 134-8630, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sahto","sequence":"additional","affiliation":[{"name":"Drug Safety Research Laboratory, Daiichi Pharmaceutical Company Ltd., 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