{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:10:50Z","timestamp":1787238650053,"version":"build-2736575974"},"reference-count":34,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>The promoting activity of the herbicide Diuron was evaluated in a medium-term rat liver carcinogenesis bioassay that uses as endpoint immunohistochemically identified glutathione S-transferase positive (GST-P+) foci. Male Wistar rats were allocated to the following groups: G1 to G6 were initiated for liver carcinogenesis by a single dose of diethylnitrosamine (DEN, 200 mg\/kg) while groups G7 and G8 received only 0.9% NaCl (DEN vehicle). From the 2nd week animals were fed a basal diet (G1 and G7) or a diet added with Diuron at 125, 500, 1250, 2500 and 2500 ppm (G2 to G5 and G8, respectively) or 200 ppm Hexaclorobenzene (HCB; G6). The animals were submitted to 70% partial hepatectomy at the 3rd week and sacrificed at the 8th week. The herbicide did not alter ALT or creatinine serum levels. No conspicuous GST-P+ foci development was registered in non-initiated rats fed Diuron at 2500 ppm. While DEN-initiated animals fed Diuron at 1250 or 2500 ppm developed mild centrilobular hypertrophy, DEN-initiated HCB-fed animals showed severe liver centrilobular hypertrophy and significant GST-P+ foci development. These findings indicate that the medium-term assay adopted in this study does not reveal any liver carcinogenesis initiating or promoting potential of Diuron in the rat.<\/jats:p>","DOI":"10.1080\/01926230701748040","type":"journal-article","created":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T10:18:04Z","timestamp":1209550684000},"page":"897-903","source":"Crossref","is-referenced-by-count":11,"title":["Diuron Lacks Promoting Potential in a Rat Liver Bioassay"],"prefix":"10.1177","volume":"35","author":[{"given":"Tony Fernando","family":"Grassi","sequence":"first","affiliation":[{"name":"UNESP S\u00e3o Paulo State University, School of Medicine, Department of Pathology, Botucatu, 18618-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cibele Aparecida","family":"Tararam","sequence":"additional","affiliation":[{"name":"UNESP S\u00e3o Paulo State University, School of Medicine, Department of Pathology, Botucatu, 18618-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L\u00facia Tozzi","family":"Spinardi-Barbisan","sequence":"additional","affiliation":[{"name":"UNESP S\u00e3o Paulo State University, School of Medicine, Department of Pathology, Botucatu, 18618-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Aparecida Cust\u00f3dio","family":"Domingues","sequence":"additional","affiliation":[{"name":"UNESP S\u00e3o Paulo State University, School of Medicine, Department of Pathology, Botucatu, 18618-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Lauro Viana","family":"de Camargo","sequence":"additional","affiliation":[{"name":"UNESP S\u00e3o Paulo State University, School of Medicine, Department of Pathology, Botucatu, 18618-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Fernando","family":"Barbisan","sequence":"additional","affiliation":[{"name":"UNESP S\u00e3o Paulo State University, Institute of Biosciences, Department of Morphology, Botucatu, 18618-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,12]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(96)03774-5"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)04089-7"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550140610"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/15.7.1451"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2006.09.002"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.2134\/jeq2003.171"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2004.04.061"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.31.040191.001345"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/53.2.245"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770120605"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-6264(67)83153-5"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(93)90011-W"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(94)00118-8"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(95)03581-8"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.98106s61331"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2003.tb01343.x"},{"key":"e_1_3_2_18_1","article-title":"Evidence on the developmental and reproductive toxicity of Diuron. 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