{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:53:53Z","timestamp":1789934033767,"version":"4.0.1"},"reference-count":30,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol Pathol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>Military use of depleted uranium (DU) has renewed interest in the toxicology of this metal. In this study, the nephrotoxicity of single exposure DU was assessed with and without pre-exposure stress. Adult male Sprague\u2013Dawley rats (n = 288) were administered a single IM dose of 0, 0.1, 0.3 or 1.0 mg\/kg DU. Corticosterone concentrations (ng\/ml, mean \u00b1 SD) were 763.65 \u00b1 130.94 and 189.80 \u00b1 90.81 for swim stressed and unstressed rats. Serum and kidney uranium concentration, hematocrit, chemistry, and renal histology were assessed on sacrifice days 1, 3, 7 and 30 post-DU-dosing. Dose related increases in serum and kidney uranium were noted. DU concentration peaked day 1 in the kidney and days 3\u20137, in the serum. Dose-related elevations of Cr and BUN concentrations were seen on days 3 and 7. A decline in serum albumin coincided with Cr and BUN suggesting protein losing nephropathy. Dose related acute tubular necrosis and proliferative glomulonephritis were seen. Tubular regeneration in low dose rats was almost complete by day 30. High dose rats had extensive tubular necrosis and delayed regeneration with focal residual chronic interstitial nephritis and cortical scarring. Glomular changes were reversed in all treatment groups by day 30. Stress exposure had no impact on any measured renal parameter.<\/jats:p>","DOI":"10.1080\/01926230701748446","type":"journal-article","created":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T10:18:04Z","timestamp":1209550684000},"page":"1000-1009","source":"Crossref","is-referenced-by-count":26,"title":["Temporal Clinical Chemistry and Microscopic Renal Effects Following Acute Uranyl Acetate Exposure"],"prefix":"10.1177","volume":"35","author":[{"given":"Kurt L.","family":"Zimmerman","sequence":"first","affiliation":[{"name":"Laboratory for Neurotoxicity Studies, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Center for Environmental and Human Toxicology, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion F.","family":"Ehrich","sequence":"additional","affiliation":[{"name":"Laboratory for Neurotoxicity Studies, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette","family":"Tobias","sequence":"additional","affiliation":[{"name":"Laboratory for Neurotoxicity Studies, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Hancock","sequence":"additional","affiliation":[{"name":"Laboratory for Neurotoxicity Studies, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hinckley","sequence":"additional","affiliation":[{"name":"Laboratory for Neurotoxicity Studies, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Binder","sequence":"additional","affiliation":[{"name":"Laboratory for Neurotoxicity Studies, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard S.","family":"Jortner","sequence":"additional","affiliation":[{"name":"Laboratory for Neurotoxicity Studies, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,12,1]]},"reference":[{"key":"b1-0351000","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/toxsci\/kfj089","volume":"90","author":"Barber DS","year":"2006","journal-title":"Toxicol Sci"},{"key":"b2-0351000","unstructured":"BrunCOlsenSAtlas of Renal Biopsy19811Philadelphia, PAW.B. Saunders20"},{"key":"b3-0351000","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.6481"},{"key":"b4-0351000","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(89)90307-2"},{"key":"b5-0351000","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(86)90302-9"},{"key":"b6-0351000","first-page":"117","volume":"41","author":"Gilman AP","year":"1998","journal-title":"Toxicol Sci"},{"key":"b7-0351000","doi-asserted-by":"publisher","DOI":"10.1007\/BF02890280"},{"key":"b8-0351000","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2006.11.014"},{"key":"b9-0351000","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1981.tb00754.x"},{"key":"b10-0351000","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)90204-6"},{"key":"b11-0351000","first-page":"81","volume":"54","author":"Kelly KJ","year":"2002","journal-title":"Minerva Urol Nefrol"},{"key":"b12-0351000","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.222"},{"key":"b13-0351000","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(89)90245-X"},{"key":"b14-0351000","volume-title":"Stress, Coping and Appraisal","author":"Lazarus R","year":"1984"},{"key":"b15-0351000","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-198909000-00001"},{"key":"b16-0351000","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1987.28.1.38"},{"key":"b17-0351000","volume-title":"Stress","volume":"4","author":"Marshall GN","year":"2000"},{"key":"b18-0351000","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-005-0006-2"},{"key":"b19-0351000","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.1999.4012"},{"key":"b20-0351000","doi-asserted-by":"publisher","DOI":"10.1007\/BF00195634"},{"key":"b21-0351000","doi-asserted-by":"publisher","DOI":"10.1177\/019262339702500406"},{"key":"b22-0351000","doi-asserted-by":"publisher","DOI":"10.1177\/030098588602300609"},{"key":"b23-0351000","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/49.1.29"},{"key":"b24-0351000","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00421.x"},{"key":"b25-0351000","doi-asserted-by":"publisher","DOI":"10.1080\/10915810500527119"},{"key":"b26-0351000","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-199604000-00002"},{"key":"b27-0351000","doi-asserted-by":"publisher","DOI":"10.1097\/01.HP.0000165451.80061.7e"},{"key":"b28-0351000","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.64.79"},{"key":"b29-0351000","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7296"},{"key":"b30-0351000","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.07.007"}],"container-title":["Toxicologic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/01926230701748446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1080\/01926230701748446","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/01926230701748446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:33:22Z","timestamp":1777620802000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1080\/01926230701748446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1080\/01926230701748446"],"URL":"https:\/\/doi.org\/10.1080\/01926230701748446","relation":{},"ISSN":["0192-6233","1533-1601"],"issn-type":[{"value":"0192-6233","type":"print"},{"value":"1533-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}