{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:05:10Z","timestamp":1767855910988,"version":"3.49.0"},"reference-count":62,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotechnology and Genetic Engineering Reviews"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1080\/02648725.2013.821283","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T11:16:27Z","timestamp":1375442187000},"page":"135-148","source":"Crossref","is-referenced-by-count":14,"title":["Metabolic engineering of plants for artemisinin synthesis"],"prefix":"10.1080","volume":"29","author":[{"given":"Moran","family":"Farhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magali","family":"Kozin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shai","family":"Duchin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Vainstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-2003-38871","volume":"69","author":"Abdin M. Z.","year":"2003","journal-title":"Planta Medica"},{"key":"CIT0002","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1007\/s00299-011-1099-6","volume":"30","author":"Alam P.","year":"2011","journal-title":"Plant Cell Reports"},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ymben.2008.07.007","volume":"11","author":"Anthony J. R.","year":"2009","journal-title":"Metabolic Engineering"},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1055\/s-0029-1185775","volume":"75","author":"Aquil S.","year":"2009","journal-title":"Planta Medica"},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1104\/pp.110.162552","volume":"154","author":"Arsenault P. R.","year":"2010","journal-title":"Plant Physiology"},{"key":"CIT0006","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1055\/s-2006-957737","volume":"63","author":"Banerjee S.","year":"1997","journal-title":"Planta Medica"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.plipres.2005.09.003","volume":"44","author":"Bouvier F.","year":"2005","journal-title":"Progress in Lipid Research"},{"key":"CIT0008","doi-asserted-by":"crossref","first-page":"7603","DOI":"10.3390\/molecules15117603","volume":"15","author":"Brown G. D.","year":"2010","journal-title":"Molecules"},{"key":"CIT0009","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1104\/pp.109.4.1337","volume":"109","author":"Chappell J.","year":"1995","journal-title":"Plant Physiology"},{"key":"CIT0010","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1055\/s-0030-1271038","volume":"77","author":"Chen J.-L.","year":"2011","journal-title":"Planta Medica"},{"key":"CIT0011","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0168-9452(00)00217-X","volume":"155","author":"Chen D. H.","year":"2000","journal-title":"Plant Science"},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1001\/jama.2012.3428","volume":"307","author":"Chico R. M.","year":"2012","journal-title":"Journal of the American Medical Association"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1016\/j.phytochem.2008.10.001","volume":"69","author":"Covello P. S.","year":"2008","journal-title":"Phytochemistry"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1016\/j.phytochem.2007.02.016","volume":"68","author":"Covello P. S.","year":"2007","journal-title":"Phytochemistry"},{"key":"CIT0015","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/s00114-005-0055-0","volume":"92","author":"Croteau R.","year":"2005","journal-title":"Naturwissenschaften"},{"key":"CIT0016","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1073\/pnas.0407360102","volume":"102","author":"Dudareva N.","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"CIT0017","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2174\/138945006776359412","volume":"7","author":"Efferth T.","year":"2006","journal-title":"Current Drug Targets"},{"key":"CIT0018","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/nbt.2054","volume":"29","author":"Farhi M.","year":"2011","journal-title":"Nature Biotechnology"},{"key":"CIT0019","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ymben.2011.05.001","volume":"13","author":"Farhi M.","year":"2011","journal-title":"Metabolic Engineering"},{"key":"CIT0020","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1017\/S1462399409001239","volume":"11","author":"Firestone G. L.","year":"2009","journal-title":"Expert Reviews in Molecular Medicine"},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1126\/science.1182612","volume":"327","author":"Graham I. A.","year":"2010","journal-title":"Science"},{"key":"CIT0022","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1126\/science.1116232","volume":"309","author":"Kappers I. F.","year":"2005","journal-title":"Science"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.1193990","volume":"330","author":"Keasling J. D.","year":"2010","journal-title":"Science"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.5661\/bger-28-1"},{"key":"CIT0025","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ymben.2011.11.005","volume":"14","author":"Kumar S.","year":"2012","journal-title":"Metabolic Engineering"},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1126\/science.336.6083.798","volume":"336","author":"Kupferschmidt K.","year":"2012","journal-title":"Science"},{"key":"CIT0027","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00299-010-0967-9","volume":"30","author":"Liu B.","year":"2011","journal-title":"Plant Cell Reports"},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s10295-008-0400-3","volume":"35","author":"Lubertozzi D.","year":"2008","journal-title":"Journal of Industrial Microbiology & Biotechnology"},{"key":"CIT0029","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1093\/pcp\/pcp149","volume":"50","author":"Ma D.","year":"2009","journal-title":"Plant and Cell Physiology"},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s11306-009-0170-6","volume":"5","author":"Ma C.","year":"2009","journal-title":"Metabolomics"},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/S0140-6736(05)61510-3","volume":"352","author":"Marsh K.","year":"1998","journal-title":"Lancet"},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.vetpar.2011.12.020","volume":"187","author":"Mazuz M. L.","year":"2012","journal-title":"Veterinary Parasitology"},{"key":"CIT0033","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1467-7652.2008.00329.x","volume":"6","author":"Moyal Ben Zvi M.","year":"2008","journal-title":"Plant Biotechnology Journal"},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S1473-3099(12)70064-6","volume":"12","author":"Nayyar G. M. L.","year":"2012","journal-title":"The Lancet Infectious Diseases"},{"key":"CIT0035","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.phytochem.2009.07.009","volume":"70","author":"Olsson M. E.","year":"2009","journal-title":"Phytochemistry"},{"key":"CIT0036","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/0141-0229(95)00216-2","volume":"18","author":"Paniego N. B.","year":"1996","journal-title":"Enzyme and Microbial Technology"},{"key":"CIT0037","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/bit.21766","volume":"100","author":"Paradise E. M.","year":"2008","journal-title":"Biotechnology and Bioengineering"},{"key":"CIT0038","doi-asserted-by":"crossref","unstructured":"Pu, G.B., Ma, D.M., Wang, H., Ye, H.C. & Liu, B.Y. (2013). Expression and localization of amorpha-4,11-diene synthase inArtemisia annuaL.Plant Molecular Biology Reporter, 31, 32\u201337.","DOI":"10.1007\/s11105-012-0472-0"},{"key":"CIT0039","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1093\/mp\/sss088","volume":"5","author":"Pulido P.","year":"2012","journal-title":"Molecular Plant"},{"key":"CIT0040","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/nature04640","volume":"440","author":"Ro D.-K.","year":"2006","journal-title":"Nature"},{"key":"CIT0041","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/nbt1110-1175","volume":"28","author":"Roberts S.","year":"2010","journal-title":"Nature Biotechnology"},{"key":"CIT0042","doi-asserted-by":"crossref","first-page":"6067","DOI":"10.1074\/jbc.M708950200","volume":"283","author":"Rontein D.","year":"2008","journal-title":"Journal of Biological Chemistry"},{"key":"CIT0043","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.phytochem.2009.10.015","volume":"71","author":"Schramek N.","year":"2010","journal-title":"Phytochemistry"},{"key":"CIT0044","doi-asserted-by":"crossref","unstructured":"Spitzer-Rimon, B., Farhi, M., Albo, B., Cna\u2019ani, A., Moyal Ben-Zvi, M., Masci, T. \u2026 Vainstein, A. (2012). EOBI, acting downstream of EOBII, regulates scent production by activating ODO1 and structural scent-related genes.The Plant Cell, 24, 5089\u20135105.","DOI":"10.1105\/tpc.112.105247"},{"key":"CIT0045","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.febslet.2006.01.065","volume":"580","author":"Teoh K. H.","year":"2006","journal-title":"FEBS Letters"},{"key":"CIT0046","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1139\/B09-032","volume":"87","author":"Teoh K. H.","year":"2009","journal-title":"Botany"},{"key":"CIT0047","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1007\/s00299-007-0420-x","volume":"26","author":"Towler M.","year":"2007","journal-title":"Plant Cell Reports"},{"key":"CIT0048","doi-asserted-by":"crossref","first-page":"19176","DOI":"10.1074\/jbc.272.31.19176","volume":"272","author":"Urban P.","year":"1997","journal-title":"Journal of Biological Chemistry"},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"e14222","DOI":"10.1371\/journal.pone.0014222","volume":"5","author":"Van Herpen T. W. J. M.","year":"2010","journal-title":"PLoS ONE"},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/466672a","volume":"466","author":"Van Noorden R.","year":"2010","journal-title":"Nature"},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/BF00231590","volume":"15","author":"Vergauwe A.","year":"1996","journal-title":"Plant Cell Reports"},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s004250000428","volume":"212","author":"Wallaart T. E.","year":"2001","journal-title":"Planta"},{"key":"CIT0053","doi-asserted-by":"crossref","unstructured":"Wang, H., Han, J., Kanagarajan., S., Lundgren, A. & Brodelius, P. E. (2013). Trichome-specific expression of the amorpha-4,11-diene 12-hydroxylase (cyp71av1) gene, encoding a key enzyme of artemisinin biosynthesis inArtemisia annua, as reported by a promoter\u2013GUS fusion.Plant Molecular Biology, 81, 119\u2013138.","DOI":"10.1007\/s11103-012-9986-y"},{"key":"CIT0055","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1467-7652.2011.00631.x","volume":"10","author":"Wang H.","year":"2012","journal-title":"Plant Biotechnology Journal"},{"key":"CIT0054","volume-title":"World Malaria Report","author":"WHO","year":"2005"},{"key":"CIT0056","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1467-7652.2011.00664.x","volume":"10","author":"Wilson S. A.","year":"2012","journal-title":"Plant Biotechnology Journal"},{"key":"CIT0057","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1038\/nbt1251","volume":"24","author":"Wu S.","year":"2006","journal-title":"Nature Biotechnology"},{"key":"CIT0058","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1055\/s-2008-1081333","volume":"74","author":"Yang R.-Y.","year":"2008","journal-title":"Planta Medica"},{"key":"CIT0059","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/mp\/ssr087","volume":"5","author":"Yu Z.-X.","year":"2012","journal-title":"Molecular Plant"},{"key":"CIT0060","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1042\/BA20080068","volume":"52","author":"Zhang L.","year":"2009","journal-title":"Biotechnology and Applied Biochemistry"},{"key":"CIT0061","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1467-7652.2010.00556.x","volume":"9","author":"Zhang Y.","year":"2011","journal-title":"Plant Biotechnology Journal"},{"key":"CIT0062","doi-asserted-by":"crossref","first-page":"21501","DOI":"10.1074\/jbc.M803090200","volume":"283","author":"Zhang Y.","year":"2008","journal-title":"Journal of Biological Chemistry"}],"container-title":["Biotechnology and Genetic Engineering Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/02648725.2013.821283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T13:18:15Z","timestamp":1498051095000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/02648725.2013.821283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1080\/02648725.2013.821283"],"URL":"https:\/\/doi.org\/10.1080\/02648725.2013.821283","relation":{},"ISSN":["0264-8725","2046-5556"],"issn-type":[{"value":"0264-8725","type":"print"},{"value":"2046-5556","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}