{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:14:57Z","timestamp":1773674097486,"version":"3.50.1"},"reference-count":45,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Hyperthermia"],"published-print":{"date-parts":[[2000,1]]},"DOI":"10.1080\/026567300285385","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T12:26:58Z","timestamp":1027686418000},"page":"1-17","source":"Crossref","is-referenced-by-count":22,"title":["Thermal destabilization of transmembrane proteins by local anaesthetics"],"prefix":"10.1080","volume":"16","author":[{"given":"G. A.","family":"Senisterra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Lepock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2009,7,9]]},"reference":[{"key":"CIT0001","first-page":"314","volume":"102","author":"ANATHAN J.","year":"1986","journal-title":"Radiation Research"},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0304-4157(92)90005-U","volume":"113","author":"BIGELOW D. J.","year":"1992","journal-title":"Biochimica et Biophysica Acta"},{"key":"CIT0004","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.1021\/bi00593a019","volume":"18","author":"BLANCHARD S. G.","year":"1979","journal-title":"Biochemistry"},{"key":"CIT0005","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0092-8674(86)90269-2","volume":"44","author":"MANDL C. J.","year":"1986","journal-title":"Cell"},{"key":"CIT0006","first-page":"3450","volume":"16","author":"BRANDTS J. F.","year":"1977","journal-title":"The involvement of spectrin in the A transitions. Biochemistry"},{"key":"CIT0007","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1098\/rstb.1984.0006","volume":"304","author":"BROWSER-RILEY F","year":"1984","journal-title":"Philosophical Transactions of the Royal Society of London B"},{"key":"CIT0008","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/00000542-199004000-00022","volume":"72","author":"BUTTERWORTH J. F.","year":"1990","journal-title":"Anesthesiology"},{"key":"CIT0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-4165(83)90016-8","volume":"756","author":"CALDERWOOD S. K.","year":"1983","journal-title":"Biochimica et Biophysica Acta"},{"key":"CIT0010","first-page":"pp. 65","author":"CAMPBELL K. P","year":"1986","journal-title":"Protein components and their roles in Sarcoplasmic Reticulum func-tion"},{"key":"CIT0011","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0006-2952(85)90261-8","volume":"34","author":"CASANOVAS A. M.","year":"1985","journal-title":"Biochemical Pharmacology"},{"key":"CIT0012","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2307\/3575934","volume":"92","author":"COSS R. A.","year":"1982","journal-title":"Radiation Research"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3109\/02656738809012407","volume":"4","author":"COSS R. A.","year":"1988","journal-title":"International Journal of Hyperthermia"},{"key":"CIT0014","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0360-3016(91)90138-T","volume":"20","author":"COSS R. A.","year":"1991","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"key":"CIT0015","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3109\/02656738909140465","volume":"5","author":"COSS R. A.","year":"1989","journal-title":"International Journal of Hyperthermid"},{"key":"CIT0016","first-page":"pp. 55","author":"COVINO B. G","year":"1987","journal-title":"Local anesthetic agents"},{"key":"CIT0017","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1021\/bi00471a020","volume":"29","author":"CURRY S.","year":"1990","journal-title":"Biochemistry"},{"key":"CIT0018","first-page":"7069","volume":"31","author":"DUBOIS B. W.","year":"1992","journal-title":"Analysis of isofluorane binding to serum albumin. Biochemistry"},{"key":"CIT0019","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1021\/bi00789a030","volume":"10","author":"FAIRBANKS G. T. L.","year":"1971","journal-title":"Biochemistry"},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/333662a0","volume":"333","author":"FRANKS N. P.","year":"1988","journal-title":"Nature"},{"key":"CIT0022","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1126\/science.1925602","volume":"254","author":"FRANKS N. P.","year":"1991","journal-title":"Science"},{"key":"CIT0023","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/jcp.1041640216","volume":"164","author":"FREEMAN M. L","year":"1995","journal-title":"Journal of Cellular Physiology"},{"key":"CIT0024","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1111\/j.1471-4159.1990.tb01954.x","volume":"54","author":"GARCIA-MARTIN E.","year":"1990","journal-title":"Journal of Neurochemistry"},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1021\/bi00434a039","volume":"28","author":"GUTIERREZ -MERINO, C., MOLINA, A., ESCUDERO, B., DIEZ, A., and LAYNEZ, J","year":"1989","journal-title":"Biochemistry"},{"key":"CIT0027","doi-asserted-by":"crossref","unstructured":"HAHN, G. M. 1982, Hyperthermia and Cancer (New York: Plenum Press).","DOI":"10.1007\/978-1-4684-4193-2"},{"key":"CIT0028","first-page":"4138","volume":"45","author":"HAHN G. M.","year":"1985","journal-title":"Cancer Research"},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3109\/02656738709140416","volume":"3","author":"KAMPINGA H. H.","year":"1987","journal-title":"International Journal of Hyperthermia"},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1021\/bi00872a018","volume":"5","author":"KIEHS K.","year":"1966","journal-title":"Biochemistry"},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"LAEMMLI U. K","year":"1970","journal-title":"Nature"},{"key":"CIT0033","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1569-2558(08)60079-X","volume":"19","author":"LEPOCK J. R","year":"1997","journal-title":"Advances in Molecular and Cell Biology"},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0005-2736(89)90399-4","volume":"980","author":"LEPOCK J. R.","year":"1989","journal-title":"Biochimica et Biophysica Acta"},{"key":"CIT0036","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1021\/bi00455a013","volume":"29","author":"LEPOCK J. R.","year":"1990","journal-title":"Biochemistry"},{"key":"CIT0037","first-page":"pp. 155","author":"LYNCH C","year":"1991","journal-title":"Alcohol and anesthetic actions on myocardial contractility"},{"key":"CIT0038","doi-asserted-by":"crossref","first-page":"5570","DOI":"10.1021\/bi00522a034","volume":"20","author":"LYSKO K.","year":"1981","journal-title":"Biochemistry"},{"key":"CIT0039","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2307\/3575605","volume":"86","author":"MAGUM B. E.","year":"1981","journal-title":"Radiation Research"},{"key":"CIT0040","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/316696a0","volume":"316","author":"MCLENNAN D. H.","year":"1985","journal-title":"Nature"},{"issue":"15710","key":"CIT0041","first-page":"717","volume":"269","author":"MIFFLIN L C.","year":"1994","journal-title":"Journal of Biological Chemistry"},{"key":"CIT0042","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0006-3495(98)77493-4","volume":"75","author":"OGAWA H.","year":"1998","journal-title":"Biophysics Journal"},{"key":"CIT0043","doi-asserted-by":"crossref","first-page":"1724\u2013","DOI":"10.1126\/science.8085162","volume":"265","author":"RAGSDALE D. S.","year":"1728","journal-title":"Science"},{"key":"CIT0046","first-page":"pp. 21","author":"SUICHARTZ G. R.","year":"1987","journal-title":"The action of local anesthetics on ion channels of excitable tissues"},{"key":"CIT0047","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/362469a0","volume":"362","author":"TOYOSHIMA C.","year":"1993","journal-title":"Nature"},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1080\/09553007714551301","volume":"32","author":"YATVIN M. B","year":"1977","journal-title":"International Journal of Radiation Biology"},{"key":"CIT0050","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1126\/science.451588","volume":"205","author":"YATVIN M. B.","year":"1979","journal-title":"Science"},{"key":"CIT0051","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/09553008214551011","volume":"42","author":"YATVIN M. B.","year":"1982","journal-title":"International Journal of Radiation Biology"},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2307\/3574994","volume":"80","author":"YAU T. M","year":"1979","journal-title":"Radiation Research"},{"key":"CIT0053","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1259\/0007-1285-53-631-687","volume":"53","author":"YAU T. M.","year":"1980","journal-title":"British Journal of Radiology"}],"container-title":["International Journal of Hyperthermia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/026567300285385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T02:49:10Z","timestamp":1497494950000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1080\/026567300285385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,7,9]]},"published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1080\/026567300285385"],"URL":"https:\/\/doi.org\/10.1080\/026567300285385","relation":{},"ISSN":["0265-6736","1464-5157"],"issn-type":[{"value":"0265-6736","type":"print"},{"value":"1464-5157","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}