{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:03:09Z","timestamp":1790366589996,"version":"4.1.0"},"reference-count":22,"publisher":"Informa UK Limited","issue":"10","funder":[{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Current Eye Research"],"published-print":{"date-parts":[[2020,10,2]]},"DOI":"10.1080\/02713683.2020.1731832","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T16:13:21Z","timestamp":1581956001000},"page":"1298-1301","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of the Efficacy of Brolucizumab with Natural Disease Progression in Wet AMD Using Clinical Data from the Phase III HAWK and HARRIER Trials and Modelled Placebo Data"],"prefix":"10.1080","volume":"45","author":[{"given":"Hansj\u00fcrgen","family":"Agostini","sequence":"first","affiliation":[{"name":"Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zufar","family":"Mulyukov","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miltiadis","family":"Tsilimbaris","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Heraklion, Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Calvo","sequence":"additional","affiliation":[{"name":"IIS-Aragon, Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicitas","family":"Bucher","sequence":"additional","affiliation":[{"name":"Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gaucher","sequence":"additional","affiliation":[{"name":"Nouvel H\u00f4pital Civil, H\u00f4pitaux Universitaires de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Pigeolet","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Colafrancesco","sequence":"additional","affiliation":[{"name":"Novartis Farmaceutica, SA, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Clemens","sequence":"additional","affiliation":[{"name":"Novartis Pharma AG, Basel, Switzerland"},{"name":"Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305702"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70145-1"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm4020343"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1984.01040031330019"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337347"},{"key":"e_1_3_4_7_1","unstructured":"Kent C. Rev Ophthalmol; 2009 [accessed 2019 Dec]. https:\/\/www.reviewofophthalmology.com\/article\/macular-degeneration-is-laser-still-relevant."},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.11.1443"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062655"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054481"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2011.2480"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.09.006"},{"key":"e_1_3_4_13_1","article-title":"Affinity and potency of RTH258 (ESBA1008), a novel inhibitor of vascular endothelial growth factor a for the treatment of retinal disorders","volume":"56","author":"Tietz J","year":"2015","unstructured":"Tietz J, Spohn G, Schmid G, Konrad J, Jampen S, Maurer P, Schmidt A, Escher D. Affinity and potency of RTH258 (ESBA1008), a novel inhibitor of vascular endothelial growth factor a for the treatment of retinal disorders. Invest Ophthalmol Vis Sci. 2015;56. [abstract 1501].","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_4_14_1","volume-title":"Presented at the European Society of Retina Specialists 15th EURETINA Congress","author":"Escher D","year":"2015","unstructured":"Escher D, Schmidt A, Steiner P, Maurer P, Weissgerber G. Single-chain antibody fragments in ophthalmology. Presented at the European Society of Retina Specialists 15th EURETINA Congress; 2015 Sep 17\u201320; Nice, France. http:\/\/abstracts.euretina.org\/."},{"key":"e_1_3_4_15_1","unstructured":"Nimz EL Van\u2019t Land CW Y\u00e1\u00f1ez JA Chastain JE. Intraocular and systemic pharmacokinetics of brolucizumab (RTH258) in nonhuman primates. Invest Ophthalmol Vis Sci. 2016;57(12):4996."},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.04.017"},{"key":"e_1_3_4_17_1","volume-title":"Presented at the American Academy of Ophthalmology 122nd Annual Meeting","author":"Dugel PU","year":"2018","unstructured":"Dugel PU, Jaffe G, Schmidt-Erfurth U, Ogura Y, Koh A, Weissgerber G, Weichselberger A, Holz FG. Brolucizumab for neovascular AMD: the 2-Year HAWK and HARRIER results. Presented at the American Academy of Ophthalmology 122nd Annual Meeting; 2018 Oct 27\u201330; Chicago, USA. http:\/\/www.aao.org\/annualmeeting\/education\/retina."},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.2018.7.issue-10"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2007.10.004"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.09.004"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.10.014"},{"key":"e_1_3_4_22_1","unstructured":"International council of ophthalmology: visual standards aspects and ranges of vision loss with emphasis on population surveys. [accessed 2019 Dec]. http:\/\/www.icoph.org\/downloads\/visualstandardsreport.pdf."},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3813"}],"container-title":["Current Eye Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/02713683.2020.1731832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T04:19:04Z","timestamp":1704773944000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/02713683.2020.1731832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,26]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10,2]]}},"alternative-id":["10.1080\/02713683.2020.1731832"],"URL":"https:\/\/doi.org\/10.1080\/02713683.2020.1731832","relation":{},"ISSN":["0271-3683","1460-2202"],"issn-type":[{"value":"0271-3683","type":"print"},{"value":"1460-2202","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,26]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=icey20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=icey20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}