{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:22:34Z","timestamp":1777472554098,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:p>Purpose: To evaluate the outcome after catheter-directed thrombolysis of occluded femoropopliteal prosthetic bypasses with the distal anastomosis above the knee.<\/jats:p>\n                  <jats:p>Material and Methods: Twenty-one patients were included in this prospective study. End-hole catheters, a bolus dose and continuous infusion of recombinant tissue-plasminogen activator (rt-PA) were used, with a median total dose of 10\u2005mg (range 7\u201320\u2005mg).<\/jats:p>\n                  <jats:p>Results: With an intra-thrombotic position of the catheter, total or subtotal lysis was obtained in 19 of 21 patients (90%). No serious complications occurred. In 9 patients, the stenoses were successfully treated with balloon angioplasty (PTA, n\u2009=\u20095), local thrombectomy\/extension of bypass (n\u2009=\u20093), or with a new bypass (n\u2009=\u20091). After a median observation time of 18 months (6\u201324), 5 patients had open bypass. Re-occlusion occurred in all (6\/6) bypasses in which no flow-limiting lesion was discovered, in all (4\/4) bypasses treated twice with thrombolysis, as well as in all bypasses in which stenoses had not been adequately treated (3\/3). One bypass re-occluded immediately due to poor runoff.<\/jats:p>\n                  <jats:p>Conclusion: In the present study, 19\/21 infra-inguinal prosthetic bypasses were successfully treated with catheter-directed thrombolysis. However, re-occlusion often took place, especially in bypasses without flow-limiting lesions. If re-occlusion occurs in a bypass in which no stenoses were revealed during the primary thrombolysis procedure, a second catheter-directed thrombolytic treatment does not seem to be warranted. Our results confirm that treatment of flow-limiting lesions is a prerequisite for maintaining patency.<\/jats:p>","DOI":"10.1080\/028418500127345190","type":"journal-article","created":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T15:10:35Z","timestamp":1090595435000},"page":"249-254","source":"Crossref","is-referenced-by-count":10,"title":["Outcome after Catheter-Directed Thrombolysis of Occluded Prosthetic Femoropopliteal Bypasses: A prospective study"],"prefix":"10.1177","volume":"41","author":[{"given":"G.","family":"Sandb\u00e6k","sequence":"first","affiliation":[{"name":"Department of Radiology, Aker Hospital, University of Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.E.","family":"Staxrud","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Aker Hospital, University of Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ros\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Aker Hospital, University of Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.-E.","family":"Slagsvold","sequence":"additional","affiliation":[{"name":"Vascular Laboratory, Aker Hospital, University of Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Stavis","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Aker Hospital, University of Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Bay","sequence":"additional","affiliation":[{"name":"Department of Radiology, Aker Hospital, University of Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Gj\u00f8lberg","sequence":"additional","affiliation":[{"name":"Department of Radiology, Aker Hospital, University of Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Kolmannskog","sequence":"additional","affiliation":[{"name":"Central Institute of Radiology (Sentrum R\u00f8ntgeninstitutt), Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,8,30]]},"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/028418500127345190","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/028418500127345190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:44:49Z","timestamp":1777383889000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1080\/028418500127345190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["10.1080\/028418500127345190"],"URL":"https:\/\/doi.org\/10.1080\/028418500127345190","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}