{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:54:32Z","timestamp":1777474472834,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p>Purpose: To evaluate the ability of contrast-enhanced magnetic resonance imaging (MRI) with Gd-EOB-DTPA in comparison with non-enhanced imaging and spiral computed tomography (CT) to provide additional information for classification and characterization of hepatocellular carcinoma.<\/jats:p>\n                  <jats:p>Material and Methods: Forty patients with histopathology-proven hepatocellular carcinoma were selected for this subgroup analysis from a phase-III multicenter study in 235 patients with known or suspected liver lesions. The primary analysis was comparison of the proportion of hepatocellular carcinoma correctly classified and characterized by combined pre-\/post-contrast MRI compared with pre-contrast MRI alone or with spiral CT. All images were evaluated on site, and in a blinded reading by three independent readers off site.<\/jats:p>\n                  <jats:p>Results: In the on-site evaluation, the lesions were correctly classified as a malignant tumor with combined MRI in 90.3%, with pre-contrast imaging alone in 82.9% and with spiral CT in 87.8% (n.s.). The proportion of correct characterization (lesion type diagnosis) with combined MRI was 85.4%, 75.6% for pre-contrast imaging, and 77.5% for spiral CT (n.s.), respectively.<\/jats:p>\n                  <jats:p>In the blinded reading, one reader showed a significant increase in the proportion of correctly characterized lesions by 27% ( P&lt;0.05). The other two readers showed a reduction in the proportion of correct characterization by 12% and 15%, respectively (n.s.).<\/jats:p>\n                  <jats:p>Conclusion: With regard to lesion classification, no difference was found between combined pre-\/post-contrast MRI and spiral CT. A non-significant trend in favor of Gd-EOB-DTPA-enhanced MRI with regard to characterization of hepatocellular carcinoma was found, although the CT scans were not optimized as the MRI scans.<\/jats:p>","DOI":"10.1080\/02841850500406795","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T18:05:18Z","timestamp":1138730718000},"page":"15-23","source":"Crossref","is-referenced-by-count":63,"title":["Imaging characteristics of hepatocellular carcinoma using the hepatobiliary contrast agent GD-EOB-DTPA"],"prefix":"10.1177","volume":"47","author":[{"given":"G.","family":"Jung","sequence":"first","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology, Kliniken der Landeshauptstadt D\u00fcsseldorf, D\u00fcsseldorf, Germany; Corporate Clinical Development Diagnostics II, Schering AG, Berlin, Germany; Berlex Laboratories, Montville, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Breuer","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology, Kliniken der Landeshauptstadt D\u00fcsseldorf, D\u00fcsseldorf, Germany; Corporate Clinical Development Diagnostics II, Schering AG, Berlin, Germany; Berlex Laboratories, Montville, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. W.","family":"Poll","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology, Kliniken der Landeshauptstadt D\u00fcsseldorf, D\u00fcsseldorf, Germany; Corporate Clinical Development Diagnostics II, Schering AG, Berlin, Germany; Berlex Laboratories, Montville, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Koch","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology, Kliniken der Landeshauptstadt D\u00fcsseldorf, D\u00fcsseldorf, Germany; Corporate Clinical Development Diagnostics II, Schering AG, Berlin, Germany; Berlex Laboratories, Montville, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Balzer","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology, Kliniken der Landeshauptstadt D\u00fcsseldorf, D\u00fcsseldorf, Germany; Corporate Clinical Development Diagnostics II, Schering AG, Berlin, Germany; Berlex Laboratories, Montville, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology, Kliniken der Landeshauptstadt D\u00fcsseldorf, D\u00fcsseldorf, Germany; Corporate Clinical Development Diagnostics II, Schering AG, Berlin, Germany; Berlex Laboratories, Montville, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"M\u00f6dder","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic and Interventional Radiology, Kliniken der Landeshauptstadt D\u00fcsseldorf, D\u00fcsseldorf, Germany; Corporate Clinical Development Diagnostics II, Schering AG, Berlin, Germany; Berlex Laboratories, Montville, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,8,30]]},"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850500406795","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850500406795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:49:22Z","timestamp":1777384162000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1080\/02841850500406795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1080\/02841850500406795"],"URL":"https:\/\/doi.org\/10.1080\/02841850500406795","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}