{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:19:15Z","timestamp":1787239155178,"version":"build-2736575974"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p>Purpose: To prospectively evaluate the incidence of biliary sludge and pseudolithiasis in children treated with ceftriaxone.<\/jats:p>\n                  <jats:p>Material and Methods: Thirty\u2010three children (14 girls, 19 boys) treated with ceftriaxone for prophylaxis ( n\u200a=\u200a13) or for an infection ( n\u200a=\u200a20) were included in this study. The incidences of biliary sludge and pseudolithiasis were investigated using ultrasonography. The ultrasonographic evaluations were performed prior to and on the 4th\u20135th days and on the 8th\u201310th days of treatment. The patients who had biliary sludge or pseudolithiasis were followed up with ultrasonographic evaluation periodically until these pathological phenomena disappeared.<\/jats:p>\n                  <jats:p>\n                    Results: Ceftriaxone was administrated intravenously at a dosage of 100\u2005mg\u2005kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2005day\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Serial gallbladder sonograms were performed before treatment and on the 4th\u20135th and 8th\u201310th days of therapy. Nineteen children developed pseudolithiasis and sludge in the gallbladder, and all were asymptomatic. No significant differences were found between the patients with normal versus abnormal sonographic findings in regard to gender, age, duration of the therapy, oral restriction except the presence of surgery ( P&lt;0.005).\n                  <\/jats:p>\n                  <jats:p>Conclusion: The combination of oral restriction and surgical procedures may be a causal factor in ceftriaxone\u2010associated biliary pseudolithiasis. It is emphasized that when gallstone and\/or sludge are detected in the gallbladder in children by ultrasonographic examination, the administration of ceftriaxone must be sought beyond other causative factors.<\/jats:p>","DOI":"10.1080\/02841850510015983","type":"journal-article","created":{"date-parts":[[2006,2,21]],"date-time":"2006-02-21T12:23:54Z","timestamp":1140524634000},"page":"112-116","source":"Crossref","is-referenced-by-count":36,"title":["Ultrasonographic findings in ceftriaxone: associated biliary sludge and pseudolithiasis in children"],"prefix":"10.1177","volume":"46","author":[{"given":"A.","family":"Ozturk","sequence":"first","affiliation":[{"name":"Department of Radiology, Department of Pediatric Surgery and Department of Pediatrics, Harran University Faculty of Medicine, Sanliurfa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Pediatric Surgery and Department of Pediatrics, Harran University Faculty of Medicine, Sanliurfa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Zeyrek","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Pediatric Surgery and Department of Pediatrics, Harran University Faculty of Medicine, Sanliurfa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Pediatric Surgery and Department of Pediatrics, Harran University Faculty of Medicine, Sanliurfa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kat","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Pediatric Surgery and Department of Pediatrics, Harran University Faculty of Medicine, Sanliurfa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Z.","family":"Ziylan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Pediatric Surgery and Department of Pediatrics, Harran University Faculty of Medicine, Sanliurfa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"E00001","doi-asserted-by":"crossref","unstructured":"Ettestad, P. J, Campbell, G. L, Welbel, S. F, Genese, C. A, Spitalny, K. C, Marchetti, C. M, et al, . Biliary complications in the treatment of unsubstantiated Lyme disease. J Infect Dis, 1995; 171: 356\u201361","DOI":"10.1093\/infdis\/171.2.356"},{"key":"E00002","unstructured":"Garni, A. A, Leung, A. K. C, Kao, C. P. Cholelithiasis in an infant with Klinefelter's syndrome. South Med J, 2002; 95: 1063\u20134"},{"key":"E00003","doi-asserted-by":"crossref","unstructured":"Herek, \u00d6, Pakdemirli, , Ko\u00e7er, N. Ceftriaxone\u2010associated biliary pseudolithiasis in children. Eur Radiol, 2001; 11: 902","DOI":"10.1007\/s003300000647"},{"key":"E00004","doi-asserted-by":"crossref","unstructured":"Kim, Y. S, Kestell, M. F, Lee, S. P. Gallbladder sludge: lessons from ceftriaxone. J Gastroenterol Hepatol, 1992; 7: 618\u201321","DOI":"10.1111\/j.1440-1746.1992.tb01496.x"},{"key":"E00005","doi-asserted-by":"crossref","unstructured":"Ko, C. W, Sekijima, J. H, Lee, S. P. Biliary sludge. Ann Intern Med, 1999; 130: 301\u201311","DOI":"10.7326\/0003-4819-130-4-199902160-00016"},{"key":"E00006","doi-asserted-by":"crossref","unstructured":"Meyboom, R. H. B, Kuiper, H, Jansen, A. Ceftriaxone and reversible cholelithiasis. Br Med J, 1988; 297: 858","DOI":"10.1136\/bmj.297.6652.858"},{"key":"E00007","doi-asserted-by":"crossref","unstructured":"Palanduz, A, Yalc\u0131n, I, Tonguc, E, et al, . Sonographic assessment of ceftriaxone\u2010associated biliary pseudulithiasis in children. 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Reversible ceftriaxone\u2010associated biliary pseudolithiasis in children. Lancet, 1988; 2: 1411\u201313","DOI":"10.1016\/S0140-6736(88)90596-X"},{"key":"E00012","doi-asserted-by":"crossref","unstructured":"Lopez, A. J, O'Keefe, P, Morrisey, M, Pickleman, J. Ceftriaxone induced cholelithiasis. Ann Intern Med, 1991; 115: 712\u20134","DOI":"10.7326\/0003-4819-115-9-712"},{"key":"E00013","doi-asserted-by":"crossref","unstructured":"Michielsen, P. P, Fierens, H, Van Maercke, Y. M. Drug\u2010induced gallbladder disease. Incidance, aetiology and management. Drug Saf, 1992; 7: 32\u201345","DOI":"10.2165\/00002018-199207010-00005"},{"key":"E00014","doi-asserted-by":"crossref","unstructured":"Shiffman, M. L, Keith, F. B, Moore, E. W. Pathogenesis of ceftriaxone\u2010associated biliary sludge: in vitro studies of calcium\u2010ceftriaxone binding and solubility. 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