{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:58:07Z","timestamp":1777474687474,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>Purpose: To propose a semi-quantitative computed tomography (CT) protocol for determining uncalcified pineal tissue (UCPT), and to evaluate its reproducibility in modification of studies showing that the degree of calcification is a potential marker of deficient melatonin production and may prove an instability marker of circadian rhythm.<\/jats:p>\n                  <jats:p>Material and Methods: Twenty-two pineal gland autopsy specimens were scanned in a skull phantom with different slice thickness twice and the uncalcified tissue visually assessed using a four-point scale. The maximum gland density was measured and its inverse graded on a non-linear four-point scale. The sum of both scores was multiplied by the gland volume to yield the UCPT. The within-subject variance of UCPT was determined and compared between scans of different slice thickness.<\/jats:p>\n                  <jats:p>Results: The UCPT of the first measurement, in arbitrary units, was 39\u00b152.5 for 1\u2005mm slice thickness, 44\u00b151.1 for 2\u2005mm, 45\u00b134.8 for 4\u2005mm, and 84\u00b158.0 for 8\u2005mm. Significant differences of within-subject variance of UCPT were found between 1 and 4\u2005mm, 1 and 8\u2005mm, and 2 and 8\u2005mm slice thicknesses ( P&lt;0.05).<\/jats:p>\n                  <jats:p>Conclusion: A superior reproducibility of the semi-quantitative CT determination of UCPT was found using 1 and 2\u2005mm slice thicknesses. These data support the use of thin slices of 1 and 2\u2005mm. The benefit in reproducibility from thin slices has to be carefully weighted against their considerably higher radiation exposure.<\/jats:p>","DOI":"10.1080\/02841850600827585","type":"journal-article","created":{"date-parts":[[2006,10,2]],"date-time":"2006-10-02T14:17:34Z","timestamp":1159798654000},"page":"865-871","source":"Crossref","is-referenced-by-count":8,"title":["Computed tomography of the human pineal gland for study of the sleep\u2013wake rhythm: reproducibility of a semi-quantitative approach"],"prefix":"10.1177","volume":"47","author":[{"given":"S. A.","family":"Schmitz","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany; Hammersmith Hospital, Imaging Sciences Department (Clinical Sciences Centre), Faculty of Medicine, Imperial College, London, United Kingdom; Department of Psychiatry and Psychotherapy, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte, Berlin, Germany; Department of Radiology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Platzek","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany; Hammersmith Hospital, Imaging Sciences Department (Clinical Sciences Centre), Faculty of Medicine, Imperial College, London, United Kingdom; Department of Psychiatry and Psychotherapy, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte, Berlin, Germany; Department of Radiology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Kunz","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany; Hammersmith Hospital, Imaging Sciences Department (Clinical Sciences Centre), Faculty of Medicine, Imperial College, London, United Kingdom; Department of Psychiatry and Psychotherapy, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte, Berlin, Germany; Department of Radiology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Mahlberg","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany; Hammersmith Hospital, Imaging Sciences Department (Clinical Sciences Centre), Faculty of Medicine, Imperial College, London, United Kingdom; Department of Psychiatry and Psychotherapy, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte, Berlin, Germany; Department of Radiology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.-J.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany; Hammersmith Hospital, Imaging Sciences Department (Clinical Sciences Centre), Faculty of Medicine, Imperial College, London, United Kingdom; Department of Psychiatry and Psychotherapy, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte, Berlin, Germany; Department of Radiology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. O.","family":"Heidenreich","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany; Hammersmith Hospital, Imaging Sciences Department (Clinical Sciences Centre), Faculty of Medicine, Imperial College, London, United Kingdom; Department of Psychiatry and Psychotherapy, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Charit\u00e9 Mitte, Berlin, Germany; Department of Radiology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,8,30]]},"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850600827585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850600827585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:49:56Z","timestamp":1777384196000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1080\/02841850600827585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1080\/02841850600827585"],"URL":"https:\/\/doi.org\/10.1080\/02841850600827585","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}