{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:58:44Z","timestamp":1777474724099,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p>Purpose: To compare single-photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI) in a cohort of patients examined for suspected dementia, including patients with no objective cognitive impairment (control group), mild cognitive impairment (MCI), and Alzheimer's disease (AD).<\/jats:p>\n                  <jats:p>\n                    Material and Methods: Twenty-four patients, eight with AD, 10 with MCI, and six controls were investigated with SPECT using\n                    <jats:sup>99m<\/jats:sup>\n                    Tc-hexamethylpropyleneamine oxime (HMPAO) and dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) with gadobutrol. Three observers performed a visual interpretation of the SPECT and MR images using a four-point visual scale.\n                  <\/jats:p>\n                  <jats:p>Results: SPECT was superior to DSC-MRI in differentiating normal from pathological. All three observers showed statistically significant results in discriminating between the control group, AD, and MCI by SPECT, with a P value of 0.0006, 0.04, and 0.01 for each observer. The statistical results were not significant for MR ( P values 0.8, 0.1, and 0.2, respectively).<\/jats:p>\n                  <jats:p>Conclusion: DSC-MRI could not replace SPECT in the diagnosis of patients with Alzheimer's disease. Several patient- and method-related improvements should be made before this method can be recommended for clinical practice.<\/jats:p>","DOI":"10.1080\/02841850600965070","type":"journal-article","created":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T16:59:02Z","timestamp":1162313942000},"page":"977-985","source":"Crossref","is-referenced-by-count":9,"title":["Can dynamic susceptibility contrast magnetic resonance imaging replace single-photon emission computed tomography in the diagnosis of patients with alzheimer's disease? a pilot study"],"prefix":"10.1177","volume":"47","author":[{"given":"L.","family":"Cavallin","sequence":"first","affiliation":[{"name":"Division of Radiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Karolinska Memory Clinic and Division of Hospital Physics, Karolinska University Hospital, Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Danielsson","sequence":"additional","affiliation":[{"name":"Division of Radiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Karolinska Memory Clinic and Division of Hospital Physics, Karolinska University Hospital, Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"\u00d6ksengard","sequence":"additional","affiliation":[{"name":"Division of Radiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Karolinska Memory Clinic and Division of Hospital Physics, Karolinska University Hospital, Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. O.","family":"Wahlund","sequence":"additional","affiliation":[{"name":"Division of Radiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Karolinska Memory Clinic and Division of Hospital Physics, Karolinska University Hospital, Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Julin","sequence":"additional","affiliation":[{"name":"Division of Radiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Karolinska Memory Clinic and Division of Hospital Physics, Karolinska University Hospital, Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Frank","sequence":"additional","affiliation":[{"name":"Division of Radiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Karolinska Memory Clinic and Division of Hospital Physics, Karolinska University Hospital, Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. L.","family":"Engman","sequence":"additional","affiliation":[{"name":"Division of Radiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Karolinska Memory Clinic and Division of Hospital Physics, Karolinska University Hospital, Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Division of Radiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Karolinska Memory Clinic and Division of Hospital Physics, Karolinska University Hospital, Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristoffersen M.","family":"Wiberg","sequence":"additional","affiliation":[{"name":"Division of Radiology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Karolinska Memory Clinic and Division of Hospital Physics, Karolinska University Hospital, Huddinge, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,8,30]]},"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850600965070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850600965070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:50:02Z","timestamp":1777384202000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1080\/02841850600965070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1080\/02841850600965070"],"URL":"https:\/\/doi.org\/10.1080\/02841850600965070","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}