{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:54:53Z","timestamp":1777474493053,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>\n                    Purpose: To evaluate O-(2-[\n                    <jats:sup>18<\/jats:sup>\n                    F]fluoroethyl)-l-tyrosine (\n                    <jats:sup>18<\/jats:sup>\n                    F-FET) uptake in mouse malignant thymoma (EL4), and its biodistribution in mice and humans.\n                  <\/jats:p>\n                  <jats:p>\n                    Material and Methods: First,\n                    <jats:sup>18<\/jats:sup>\n                    F-FET uptake in EL4 cells was examined in an in vitro study. Second, the kinetics of\n                    <jats:sup>18<\/jats:sup>\n                    F-FET uptake and its biodistribution were examined in mice after subcutaneous injection of EL4 cells and complete Freund's adjuvant. Finally, the kinetics of\n                    <jats:sup>18<\/jats:sup>\n                    F-FET uptake and its biodistribution in healthy human volunteers were examined.\n                  <\/jats:p>\n                  <jats:p>\n                    Results: In an in vitro study,\n                    <jats:sup>18<\/jats:sup>\n                    F-FET was extensively incorporated in EL4 cells. In an animal study,\n                    <jats:sup>18<\/jats:sup>\n                    F-FET accumulation in normal organs peaked within 30\u2005min postinjection. The mean ratios of\n                    <jats:sup>18<\/jats:sup>\n                    F-FET uptake in tumors and in inflammatory lesions to that in muscle tissue at 60\u2005min postadministration were 2.18 (range 2.00\u20132.29) and 1.04 (range 0.95\u20131.14), respectively. In a human study, static images were taken 60\u2005min after\n                    <jats:sup>18<\/jats:sup>\n                    F-FET administration. Mean standardized uptake values (SUVs) of the liver (1.52, range 1.38\u20131.71) and kidneys (1.90, range 1.74\u20132.24) were nearly equal or slightly higher than that of muscle tissue (1.19, range 0.99\u20131.33).\n                  <\/jats:p>\n                  <jats:p>\n                    Conclusion: This study demonstrates that\n                    <jats:sup>18<\/jats:sup>\n                    F-FET accumulation in thymoma is significantly higher than in normal organs.\n                    <jats:sup>18<\/jats:sup>\n                    F-FET could be a useful tracer for tumor imaging.\n                  <\/jats:p>","DOI":"10.1080\/02841850600979055","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T19:45:08Z","timestamp":1164829508000},"page":"1042-1048","source":"Crossref","is-referenced-by-count":5,"title":["O-(2-[\n                    <sup>18<\/sup>\n                    F]fluoroethyl)-l-tyrosine (\n                    <sup>18<\/sup>\n                    F-FET) uptake in mouse thymoma cells, and its biodistribution in mice and human volunteers"],"prefix":"10.1177","volume":"47","author":[{"given":"K.","family":"Abe","sequence":"first","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, and Department of Health Sciences, School of Medicine, Kyushu University, Fukuoka, Japan; Department of Radiological Technology, Kyushu University Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, and Department of Health Sciences, School of Medicine, Kyushu University, Fukuoka, Japan; Department of Radiological Technology, Kyushu University Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, and Department of Health Sciences, School of Medicine, Kyushu University, Fukuoka, Japan; Department of Radiological Technology, Kyushu University Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, and Department of Health Sciences, School of Medicine, Kyushu University, Fukuoka, Japan; Department of Radiological Technology, Kyushu University Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, and Department of Health Sciences, School of Medicine, Kyushu University, Fukuoka, Japan; Department of Radiological Technology, Kyushu University Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sawamoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, and Department of Health Sciences, School of Medicine, Kyushu University, Fukuoka, Japan; Department of Radiological Technology, Kyushu University Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Himuro","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, and Department of Health Sciences, School of Medicine, Kyushu University, Fukuoka, Japan; Department of Radiological Technology, Kyushu University Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Graduate School of Medical Sciences, and Department of Health Sciences, School of Medicine, Kyushu University, Fukuoka, Japan; Department of Radiological Technology, Kyushu University Hospital, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,8,30]]},"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850600979055","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850600979055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:49:26Z","timestamp":1777384166000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1080\/02841850600979055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1080\/02841850600979055"],"URL":"https:\/\/doi.org\/10.1080\/02841850600979055","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}