{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:00:25Z","timestamp":1777474825545,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p>Background: In the heart, the creatine kinase system plays an important role in energy reserves, and myocardial energy production essentially depends upon fatty acid metabolism.<\/jats:p>\n                  <jats:p>Purpose: To examine myocardial creatine (CR) concentration and altered cardiac fatty acid metabolism in various forms of heart disease.<\/jats:p>\n                  <jats:p>\n                    Material and Methods: Myocardial CR concentration of the septum was measured by gated\n                    <jats:sup>1<\/jats:sup>\n                    H magnetic resonance spectroscopy (MRS), applying a point-resolved spectroscopy (PRESS) sequence in 34 patients with heart disease. Of these patients, 14 underwent\n                    <jats:sup>123<\/jats:sup>\n                    I BMIPP (radioactive fatty acid analogue) myocardial scintigraphy to evaluate myocardial fatty acid metabolism. Cardiac\n                    <jats:sup>123<\/jats:sup>\n                    I BMIPP uptake was calculated as the heart-to-mediastinum count ratio.\n                  <\/jats:p>\n                  <jats:p>\n                    Results: Myocardial CR concentration correlated positively with the left ventricular ejection fraction (LVEF) by echocardiography ( R\u00a0=\u00a00.61, P&lt;0.001, n\u00a0=\u00a034), suggesting that the degree of reduced CR is related to the severity of contractile dysfunction. Cardiac\n                    <jats:sup>123<\/jats:sup>\n                    I BMIPP uptake also correlated positively with LVEF (initial image, R\u00a0=\u00a00.60, P&lt;0.05; delayed image, R\u00a0=\u00a00.63, P&lt;0.05; n\u00a0=\u00a014). There was a significant correlation between myocardial CR and cardiac\n                    <jats:sup>123<\/jats:sup>\n                    I BMIPP uptake (initial image, R\u00a0=\u00a00.77, P&lt;0.01; delayed image, R\u00a0=\u00a00.82, P&lt;0.001; n\u00a0=\u00a014).\n                  <\/jats:p>\n                  <jats:p>Conclusion: Our study suggests an association between CR depletion and impaired fatty acid metabolism in various forms of heart diseases.<\/jats:p>","DOI":"10.1080\/02841850701280809","type":"journal-article","created":{"date-parts":[[2007,5,23]],"date-time":"2007-05-23T21:01:19Z","timestamp":1179954079000},"page":"436-443","source":"Crossref","is-referenced-by-count":10,"title":["Creatine depletion and altered fatty acid metabolism in diseased human hearts: clinical investigation using\n                    <sup>1<\/sup>\n                    h magnetic resonance spectroscopy and\n                    <sup>123<\/sup>\n                    I BMIPP myocardial scintigraphy"],"prefix":"10.1177","volume":"48","author":[{"given":"I.","family":"Nakae","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Respiratory Medicine, and Department of General Medicine, Shiga University of Medical Science, Seta, Otsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Mitsunami","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Respiratory Medicine, and Department of General Medicine, Shiga University of Medical Science, Seta, Otsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Respiratory Medicine, and Department of General Medicine, Shiga University of Medical Science, Seta, Otsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Respiratory Medicine, and Department of General Medicine, Shiga University of Medical Science, Seta, Otsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,8,30]]},"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850701280809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850701280809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:50:23Z","timestamp":1777384223000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1080\/02841850701280809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1080\/02841850701280809"],"URL":"https:\/\/doi.org\/10.1080\/02841850701280809","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}