{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:29:58Z","timestamp":1792448998963,"version":"4.5.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>Background: Gadolinium contrast media (Gd-CM) are regarded as non-nephrotoxic or considerably less nephrotoxic than iodine contrast media (I-CM), and have therefore come to be used as a substitute for I-CM in patients with renal insufficiency in a variety of radiographic examinations.<\/jats:p>\n                  <jats:p>Purpose: To investigate renal histomorphological changes caused by Gd-CM in comparison with I-CM after renal X-ray arteriography in an ischemic porcine model, and to evaluate these changes in relation to the nephrotoxicity of the CM used.<\/jats:p>\n                  <jats:p>Material and Methods: Test solutions: gadopentetate, gadodiamide, iohexol, gadobutrol, iopromide, iodixanol, mannitol, and saline. The experiments were performed on 152 animals. Each pig was randomized to receive one test solution injected into the balloon-occluded (10\u2005min) right renal artery. The kidneys were evaluated histomorphologically. The severity of histomorphological changes was graded subjectively: 1\u00a0=\u00a0minimal, 2\u00a0=\u00a0mild, 3\u00a0=\u00a0moderate, and 4\u00a0=\u00a0marked.<\/jats:p>\n                  <jats:p>Results: The main histological changes were 1) proximal tubular and glomerular necrosis, 2) hemorrhage\/congestion of the cortex, medulla, and glomeruli, 3) proximal tubular vacuolation, and 4) protein-filled tubules in the cortex and medulla. Necrosis and hemorrhage\/congestion were more frequent after injections with gadopentetate, mannitol solution iso-osmotic to gadopentetate, and gadobutrol compared to all other groups ( P&lt;0.001). The degree of necrosis and hemorrhage\/congestion was related to the degree of impairment of renal function, but inversely related to vacuolation and tubular protein filling.<\/jats:p>\n                  <jats:p>Conclusion: In ischemic porcine kidneys, the histomorphological changes caused by Gd-CM are similar to those caused by I-CM. Vacuolation appears to be independent of the osmolality and viscosity of the CM, and does not seem to be an indicator of renal impairment. \u201cHigh-osmolal\u201d Gd-CM are more nephrotoxic than \u201clow- and iso-osmolal\u201d I-CM when compared in equal volumes of concentrations, resulting in equal X-ray attenuation.<\/jats:p>","DOI":"10.1080\/02841850701663442","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T22:03:44Z","timestamp":1196114624000},"page":"1109-1119","source":"Crossref","is-referenced-by-count":11,"title":["Histomorphological changes after renal X-ray arteriography using iodine and gadolinium contrast media in an ischemic porcine model"],"prefix":"10.1177","volume":"48","author":[{"given":"B.","family":"Elmst\u00e5hl","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology and Department of Experimental Research, Malm\u00f6 University Hospital, Lund University, Malm\u00f6, Sweden;, Department of Safety, Preclinical Sciences, Biology, GE Healthcare, Oslo, Norway;, Competence Center for Clinical Research, University Hospital, Lund University, Lund, Sweden;, Department of Radiology, Lasarettet Trelleborg, Lund University, Trelleborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Leander","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Department of Experimental Research, Malm\u00f6 University Hospital, Lund University, Malm\u00f6, Sweden;, Department of Safety, Preclinical Sciences, Biology, GE Healthcare, Oslo, Norway;, Competence Center for Clinical Research, University Hospital, Lund University, Lund, Sweden;, Department of Radiology, Lasarettet Trelleborg, Lund University, Trelleborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Department of Experimental Research, Malm\u00f6 University Hospital, Lund University, Malm\u00f6, Sweden;, Department of Safety, Preclinical Sciences, Biology, GE Healthcare, Oslo, Norway;, Competence Center for Clinical Research, University Hospital, Lund University, Lund, Sweden;, Department of Radiology, Lasarettet Trelleborg, Lund University, Trelleborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W.","family":"Doughty","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Department of Experimental Research, Malm\u00f6 University Hospital, Lund University, Malm\u00f6, Sweden;, Department of Safety, Preclinical Sciences, Biology, GE Healthcare, Oslo, Norway;, Competence Center for Clinical Research, University Hospital, Lund University, Lund, Sweden;, Department of Radiology, Lasarettet Trelleborg, Lund University, Trelleborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.-M.","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Department of Experimental Research, Malm\u00f6 University Hospital, Lund University, Malm\u00f6, Sweden;, Department of Safety, Preclinical Sciences, Biology, GE Healthcare, Oslo, Norway;, Competence Center for Clinical Research, University Hospital, Lund University, Lund, Sweden;, Department of Radiology, Lasarettet Trelleborg, Lund University, Trelleborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bj\u00f6rk","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Department of Experimental Research, Malm\u00f6 University Hospital, Lund University, Malm\u00f6, Sweden;, Department of Safety, Preclinical Sciences, Biology, GE Healthcare, Oslo, Norway;, Competence Center for Clinical Research, University Hospital, Lund University, Lund, Sweden;, Department of Radiology, Lasarettet Trelleborg, Lund University, Trelleborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Alm\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Department of Experimental Research, Malm\u00f6 University Hospital, Lund University, Malm\u00f6, Sweden;, Department of Safety, Preclinical Sciences, Biology, GE Healthcare, Oslo, Norway;, Competence Center for Clinical Research, University Hospital, Lund University, Lund, Sweden;, Department of Radiology, Lasarettet Trelleborg, Lund University, Trelleborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Nyman","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Department of Experimental Research, Malm\u00f6 University Hospital, Lund University, Malm\u00f6, Sweden;, Department of Safety, Preclinical Sciences, Biology, GE Healthcare, Oslo, Norway;, Competence Center for Clinical Research, University Hospital, Lund University, Lund, Sweden;, Department of Radiology, Lasarettet Trelleborg, Lund University, Trelleborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,8,30]]},"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850701663442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850701663442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:50:11Z","timestamp":1777384211000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1080\/02841850701663442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1080\/02841850701663442"],"URL":"https:\/\/doi.org\/10.1080\/02841850701663442","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}