{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:02:50Z","timestamp":1777474970518,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p>Background: Patients with hypercholesterolemia of 60 years and older have an increased risk for white matter brain lesions and dementia.<\/jats:p>\n                  <jats:p>Purpose: To investigate whether patients with familial hypercholesterolemia (FH) develop white matter lesions at 3-Tesla (T) MRI as early as in midlife.<\/jats:p>\n                  <jats:p>Material and Methods: Non-diabetic, nonsmoking, and non-hypertensive heterozygous FH patients on treatment with maximally tolerated dose of a statin for more than 5 years ( n\u00a0=\u00a014) and matched controls ( n\u00a0=\u00a022) aged 25 to 60 years of age were studied. Imaging was performed at 3T with a fluid-attenuated T2-weighted MR pulse sequence and a T1-weighted spin-echo pulse sequence following 10\u00a0ml of i.v. gadopentetate dimeglumine. Images were evaluated by two independent readers. Fasting blood samples were taken. Student's t test was employed at P&lt;0.05.<\/jats:p>\n                  <jats:p>Results: Three volunteers and one FH patient had white matter lesions ( P&lt;0.53). No other evidence of past ischemic stroke was observed. Mean total serum cholesterol and low-density lipoprotein (LDL) cholesterol were significantly higher in the FH group (6.0\u00b11.1 vs. 5.1\u00b10.9\u00a0mmol\/l, P&lt;0.02 and 4.1\u00b10.9 vs. 3.1\u00b10.8\u00a0mmol\/l, P&lt;0.004, respectively).<\/jats:p>\n                  <jats:p>Conclusion: Heterozygous FH patients on statin treatment in the age range of 25 to 60 years are not at increased risk of white matter lesions at 3T MRI.<\/jats:p>","DOI":"10.1080\/02841850701736263","type":"journal-article","created":{"date-parts":[[2008,2,26]],"date-time":"2008-02-26T11:47:40Z","timestamp":1204026460000},"page":"184-189","source":"Crossref","is-referenced-by-count":7,"title":["White matter brain lesions in midlife familial hypercholesterolemic patients at 3-tesla magnetic resonance imaging"],"prefix":"10.1177","volume":"49","author":[{"given":"S. A.","family":"Schmitz","sequence":"first","affiliation":[{"name":"Imaging Sciences Department and Clinical Research Facility, MRC Clinical Sciences Centre, London, UK;, Lipid Clinic, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. P.","family":"O'Regan","sequence":"additional","affiliation":[{"name":"Imaging Sciences Department and Clinical Research Facility, MRC Clinical Sciences Centre, London, UK;, Lipid Clinic, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Imaging Sciences Department and Clinical Research Facility, MRC Clinical Sciences Centre, London, UK;, Lipid Clinic, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Neuwirth","sequence":"additional","affiliation":[{"name":"Imaging Sciences Department and Clinical Research Facility, MRC Clinical Sciences Centre, London, UK;, Lipid Clinic, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Potter","sequence":"additional","affiliation":[{"name":"Imaging Sciences Department and Clinical Research Facility, MRC Clinical Sciences Centre, London, UK;, Lipid Clinic, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Tosi","sequence":"additional","affiliation":[{"name":"Imaging Sciences Department and Clinical Research Facility, MRC Clinical Sciences Centre, London, UK;, Lipid Clinic, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. V.","family":"Hajnal","sequence":"additional","affiliation":[{"name":"Imaging Sciences Department and Clinical Research Facility, MRC Clinical Sciences Centre, London, UK;, Lipid Clinic, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. P.","family":"Naoumova","sequence":"additional","affiliation":[{"name":"Imaging Sciences Department and Clinical Research Facility, MRC Clinical Sciences Centre, London, UK;, Lipid Clinic, Hammersmith Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,3,1]]},"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850701736263","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850701736263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:51:00Z","timestamp":1777384260000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1080\/02841850701736263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1080\/02841850701736263"],"URL":"https:\/\/doi.org\/10.1080\/02841850701736263","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}