{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:27:59Z","timestamp":1791044879863,"version":"4.1.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>Background: Acute inflammatory responses have been thought to play a central role in ischemia-reperfusion injury after acute ischemic stroke. Superparamagnetic iron oxide (SPIO) particles have been known to enable in-vivo monitoring of macrophage infiltration by magnetic resonance imaging (MRI) in the experimental ischemic rat brain.<\/jats:p>\n                  <jats:p>Purpose: To determine whether the accumulation of macrophages could be seen in vivo in a reperfusion animal model after focal cerebral ischemia using SPIO-enhanced MRI.<\/jats:p>\n                  <jats:p>Material and Methods: Thirty-four adult male rats were enrolled in this study. SPIO particles were injected into the rats at different time points after 1-hour transient occlusion of the middle cerebral artery, and three-dimensional (3D) T2*-weighted magnetic resonance (MR) images with a gradient-echo sequence were performed 24 hours later. Histochemical iron staining was compared with T2* signal abnormalities.<\/jats:p>\n                  <jats:p>Results: At days 3 and 4 post-reperfusion, focal areas of signal loss indicating local accumulation of SPIO particles appeared in a part of the damaged brain. Areas of signal loss corresponded to local accumulation of iron-laden macrophages in histologic sections, and SPIO-induced signal loss indicated active macrophage transmigration into the reperfused brain.<\/jats:p>\n                  <jats:p>Conclusion: SPIO-enhanced MRI demonstrated through in-vivo monitoring that macrophages participate in reperfusion injury at early stages of injury development. SPIO-enhanced MRI could be a useful tool to examine the inflammatory mechanisms involved in reperfusion brain injury.<\/jats:p>","DOI":"10.1080\/02841850802020484","type":"journal-article","created":{"date-parts":[[2008,5,12]],"date-time":"2008-05-12T13:08:42Z","timestamp":1210597722000},"page":"580-588","source":"Crossref","is-referenced-by-count":22,"title":["Imaging of the inflammatory response in reperfusion injury after transient cerebral ischemia in rats: correlation of superparamagnetic iron oxide-enhanced magnetic resonance imaging with histopathology"],"prefix":"10.1177","volume":"49","author":[{"given":"J.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Radiology and Anatomy, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. I.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology and Anatomy, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.-K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology and Anatomy, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology and Anatomy, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology and Anatomy, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. K.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Radiology and Anatomy, Yonsei University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,6,1]]},"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850802020484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850802020484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:51:13Z","timestamp":1777384273000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1080\/02841850802020484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1080\/02841850802020484"],"URL":"https:\/\/doi.org\/10.1080\/02841850802020484","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}