{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:03:50Z","timestamp":1777475030553,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>Background: In multiple sclerosis (MS), brain atrophy assessed by linear measurements of ventricular widths has been reported to be well correlated with three-dimensional (3D) measurements. Therefore, serial linear measurements with no need for advanced 3D evaluation may be proven to be robust markers of irreversible, destructive changes.<\/jats:p>\n                  <jats:p>Purpose: To evaluate the rate of supratentorial ventricular enlargement representing four decades of disease span.<\/jats:p>\n                  <jats:p>Material and Methods: 37 MS patients with disease duration at baseline ranging from 1 to 33 years were included. The mean time of the individual magnetic resonance imaging (MRI) follow-up was 9.25 years (range 7.3\u201310 years). Enlargement rate of the third and lateral ventricles was studied over time by applying three linear measurements on axial 5-mm T1-weighted MRI images.<\/jats:p>\n                  <jats:p>Results: Progression of supratentorial ventricular widths during 9 years\u2019 follow-up was found. The mean annual width increase of the third ventricle was 0.20 mm ( P&lt;0.001, 95% confidence interval [CI] 0.15\u20130.25), for the frontal horn width 0.32 mm ( P&lt;0.001, 95% CI 0.23\u20130.40), and increase of the intercaudate distance was 0.26 mm ( P&lt;0.001, 95% CI 0.19\u20130.33). The association between these three measurements and disability status persisted at the time of follow-up.<\/jats:p>\n                  <jats:p>Conclusion: We found uniform ventricular enlargement progression during four decades of disease span, suggesting unchanging total brain atrophy progression over time.<\/jats:p>","DOI":"10.1080\/02841850802039898","type":"journal-article","created":{"date-parts":[[2008,6,20]],"date-time":"2008-06-20T10:07:22Z","timestamp":1213956442000},"page":"570-579","source":"Crossref","is-referenced-by-count":19,"title":["Rate of ventricular enlargement in multiple sclerosis: a nine-year magnetic resonance imaging follow-up study"],"prefix":"10.1177","volume":"49","author":[{"given":"J.","family":"Martola","sequence":"first","affiliation":[{"name":"Division of Radiology, Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden; Division of Neurology, Department of Clinical Neuroscience, Karolinska Institute Huddinge, Stockholm, Sweden; Medical Statistics Unit, Department of Learning, Informatics, Management, and Ethics (LIME), Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Stawiarz","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden; Division of Neurology, Department of Clinical Neuroscience, Karolinska Institute Huddinge, Stockholm, Sweden; Medical Statistics Unit, Department of Learning, Informatics, Management, and Ethics (LIME), Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fredrikson","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden; Division of Neurology, Department of Clinical Neuroscience, Karolinska Institute Huddinge, Stockholm, Sweden; Medical Statistics Unit, Department of Learning, Informatics, Management, and Ethics (LIME), Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hillert","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden; Division of Neurology, Department of Clinical Neuroscience, Karolinska Institute Huddinge, Stockholm, Sweden; Medical Statistics Unit, Department of Learning, Informatics, Management, and Ethics (LIME), Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden; Division of Neurology, Department of Clinical Neuroscience, Karolinska Institute Huddinge, Stockholm, Sweden; Medical Statistics Unit, Department of Learning, Informatics, Management, and Ethics (LIME), Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Flodmark","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden; Division of Neurology, Department of Clinical Neuroscience, Karolinska Institute Huddinge, Stockholm, Sweden; Medical Statistics Unit, Department of Learning, Informatics, Management, and Ethics (LIME), Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Aspelin","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden; Division of Neurology, Department of Clinical Neuroscience, Karolinska Institute Huddinge, Stockholm, Sweden; Medical Statistics Unit, Department of Learning, Informatics, Management, and Ethics (LIME), Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kristoffersen Wiberg","sequence":"additional","affiliation":[{"name":"Division of Radiology, Department of Clinical Science, Intervention, and Technology, Karolinska Institute, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden; Division of Neurology, Department of Clinical Neuroscience, Karolinska Institute Huddinge, Stockholm, Sweden; Medical Statistics Unit, Department of Learning, Informatics, Management, and Ethics (LIME), Karolinska Institute, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,6,1]]},"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850802039898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850802039898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:51:14Z","timestamp":1777384274000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1080\/02841850802039898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1080\/02841850802039898"],"URL":"https:\/\/doi.org\/10.1080\/02841850802039898","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}