{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:52:27Z","timestamp":1787061147402,"version":"build-2736575974"},"reference-count":0,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>Background: The contrast medium (CM) dose-to-eGFR (estimated glomerular filtration rate) ratio has recently been advocated to express systemic exposure to CM in assessing the risk of contrast medium-induced nephropathy (CIN).<\/jats:p>\n                  <jats:p>Purpose: To evaluate how CIN risk might vary with decreasing eGFR at fixed CM-dose\/eGFR ratios and other CIN risk factors, and to find a relatively safe CM-dose\/eGFR ratio.<\/jats:p>\n                  <jats:p>Material and Methods: 391 patients underwent primary coronary angioplasty for ST-segment elevation acute myocardial infarction. CM dose (grams iodine; g I), eGFR (ml\/min), and preprocedural CIN risk factors were entered into a multiple logistic regression model. From the established statistical model, the probability of CIN (\u226544.2 \u00b5mol\/l serum creatinine rise or oliguria\/anuria) was calculated at various eGFR levels based on g-I\/eGFR ratios of 1:2, 1:1, 2:1, and 3:1.<\/jats:p>\n                  <jats:p>Results: At a g-I\/eGFR ratio &lt;1 the risk of CIN was 3%, while it was 25% at a g-I\/eGFR ratio \u22651. Independent predictors of CIN were CM dose, eGFR, left ventricular ejection fraction (LVEF) and cardiogenic shock (ROC area =0.87). An estimated CIN risk of 10% would for example occur at a g-I\/eGFR ratio of 1.5:1 in patients with 50% LVEF without shock. At a 1:2, 1:1, 2:1, and 3:1 g-I\/eGFR ratio with 50% LVEF without shock, the CIN risk was about 2, 6, 18, and 30%, respectively, over a wide range of eGFR values (30\u201390 ml\/min). At a 1:1 g-I\/eGFR ratio with 50% LVEF+shock, 25% LVEF without shock, or 25% LVEF+shock, the CIN risk was 20, 55, and 80%, respectively.<\/jats:p>\n                  <jats:p>Conclusion: Relating CM dose to eGFR appears to be an attractive pharmacotoxic model to assess CIN risk. At fixed CM-dose\/eGFR ratios, CIN risk increased marginally with decreasing eGFR. Limiting the CM dose in g I numerically to the eGFR value in ml\/min or less may be relatively safe with regard to CIN, unless multiple risk factors are present.<\/jats:p>","DOI":"10.1080\/02841850802050762","type":"journal-article","created":{"date-parts":[[2008,5,12]],"date-time":"2008-05-12T13:08:40Z","timestamp":1210597720000},"page":"658-667","source":"Crossref","is-referenced-by-count":115,"title":["Contrast medium dose-to-gfr ratio: a measure of systemic exposure to predict contrast-induced nephropathy after percutaneous coronary intervention"],"prefix":"10.1177","volume":"49","author":[{"given":"U.","family":"Nyman","sequence":"first","affiliation":[{"name":"Department of Radiology, Lasarettet Trelleborg, University of Lund, Trelleborg, Sweden; Competence Center for Clinical Research, University Hospital, University of Lund, Lund, Sweden; Department of Clinical Science, Intervention, and Technology (CLINTEC), Division of Radiology, Karolinska Institute at Karolinska University Hospital \u2013 Campus Huddinge, Stockholm, Sweden; Centro Cardiologico Monzino, I.R.C.C.S., Institute of Cardiology of the University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bj\u00f6rk","sequence":"additional","affiliation":[{"name":"Department of Radiology, Lasarettet Trelleborg, University of Lund, Trelleborg, Sweden; Competence Center for Clinical Research, University Hospital, University of Lund, Lund, Sweden; Department of Clinical Science, Intervention, and Technology (CLINTEC), Division of Radiology, Karolinska Institute at Karolinska University Hospital \u2013 Campus Huddinge, Stockholm, Sweden; Centro Cardiologico Monzino, I.R.C.C.S., Institute of Cardiology of the University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Aspelin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Lasarettet Trelleborg, University of Lund, Trelleborg, Sweden; Competence Center for Clinical Research, University Hospital, University of Lund, Lund, Sweden; Department of Clinical Science, Intervention, and Technology (CLINTEC), Division of Radiology, Karolinska Institute at Karolinska University Hospital \u2013 Campus Huddinge, Stockholm, Sweden; Centro Cardiologico Monzino, I.R.C.C.S., Institute of Cardiology of the University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Marenzi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Lasarettet Trelleborg, University of Lund, Trelleborg, Sweden; Competence Center for Clinical Research, University Hospital, University of Lund, Lund, Sweden; Department of Clinical Science, Intervention, and Technology (CLINTEC), Division of Radiology, Karolinska Institute at Karolinska University Hospital \u2013 Campus Huddinge, Stockholm, Sweden; Centro Cardiologico Monzino, I.R.C.C.S., Institute of Cardiology of the University of Milan, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,7,1]]},"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850802050762","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850802050762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:51:17Z","timestamp":1777384277000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1080\/02841850802050762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1080\/02841850802050762"],"URL":"https:\/\/doi.org\/10.1080\/02841850802050762","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}