{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:34:20Z","timestamp":1777476860597,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Radiol"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p>Background: Contrast-induced nephropathy is a serious complication of diagnostic and interventional procedures.<\/jats:p>\n                  <jats:p>Purpose: To evaluate the nephrotoxicity of high- and low-osmolar contrast media (HOCM, LOCM) on kidneys in Sprague-Dawley rats. Telmisartan was administered to confirm its protective role against nephrotoxicity induced by contrast media.<\/jats:p>\n                  <jats:p>Material and Methods: Sixty male rats were randomly divided into six groups ( n=10\/group). Glycerin was given to all rats except controls to induce renal injury. HOCM (diatrizoate) or LOCM (iohexol) (10 ml\/kg b.w., 300 mg I\/ml) was given through a caudal vein. Serum creatinine level was measured by an automatical biochemical analyzer. Caspase-3 activity and Angiotensin II (Ang II) level of renal tissue were detected by fluorometric method and radioimmunoassay, respectively. The renal injury was also assessed by hematoxylin and eosin and TdT-mediated deoxyuridine nick end-labeling staining.<\/jats:p>\n                  <jats:p>Results: In diatrizoate-injected rats, serum creatinine level was increased ( P&lt;0.001). There was no significant difference between iohexol animals and glycerol controls in the level of serum creatinine. The renal caspase-3 activity and Ang II levels in HOCM and LOCM groups were higher than those in glycerol control group ( P&lt;0.001). The percentage of apoptotic tubular cells and pathological scores were lower in the iohexol animals than that in the diatrizoate animals ( P&lt;0.001). In the groups pretreated with telmisartan, no increase in the levels of serum creatinine, renal Ang II, and caspase-3 activity was observed ( P&gt;0.05). The renal injuries induced by contrast media were alleviated.<\/jats:p>\n                  <jats:p>Conclusion: Both HOCM (diatrizoate) and LOCM (iohexol) could cause renal tubular cell apoptosis in the kidneys damaged by glycerin. LOCM was less toxic to rat kidneys than HOCM. Caspase-3 and Ang II might play a role in renal tubular cell apoptosis induced by contrast media. Telmisartan protected the renal tissue from nephrotoxicity induced by contrast media.<\/jats:p>","DOI":"10.1080\/02841850902995544","type":"journal-article","created":{"date-parts":[[2009,5,19]],"date-time":"2009-05-19T01:11:34Z","timestamp":1242695494000},"page":"754-759","source":"Crossref","is-referenced-by-count":24,"title":["The protective role of telmisartan against nephrotoxicity induced by X-ray contrast media in rat model"],"prefix":"10.1177","volume":"50","author":[{"given":"Shao Bin","family":"Duan","sequence":"first","affiliation":[{"name":"Institute of Nephrology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu You","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang Qing","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pian","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zou","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You Ming","family":"Peng","sequence":"additional","affiliation":[{"name":"Institute of Nephrology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,9,1]]},"container-title":["Acta Radiologica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850902995544","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1080\/02841850902995544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:57:04Z","timestamp":1777384624000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1080\/02841850902995544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1080\/02841850902995544"],"URL":"https:\/\/doi.org\/10.1080\/02841850902995544","relation":{},"ISSN":["0284-1851","1600-0455"],"issn-type":[{"value":"0284-1851","type":"print"},{"value":"1600-0455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}