{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:28:23Z","timestamp":1791178103806,"version":"4.1.0"},"reference-count":39,"publisher":"Informa UK Limited","issue":"7","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Current Medical Research and Opinion"],"published-print":{"date-parts":[[2022,7,3]]},"DOI":"10.1080\/03007995.2022.2076474","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T07:12:10Z","timestamp":1652685130000},"page":"1237-1250","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":11,"title":["Oral, intranasal, and intravenous abuse potential of serdexmethylphenidate, a novel prodrug of d-methylphenidate"],"prefix":"10.1080","volume":"38","author":[{"given":"Megan J.","family":"Shram","sequence":"first","affiliation":[{"name":"Altreos Research Partners, Inc, Toronto, Canada"},{"name":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Setnik","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada"},{"name":"Altasciences, Laval, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Webster","sequence":"additional","affiliation":[{"name":"Lifetree Medical, Salt Lake City, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Guenther","sequence":"additional","affiliation":[{"name":"KemPharm, Inc, Celebration, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis C.","family":"Mickle","sequence":"additional","affiliation":[{"name":"KemPharm, Inc, Celebration, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene","family":"Braeckman","sequence":"additional","affiliation":[{"name":"KemPharm, Inc, Celebration, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Kanski","sequence":"additional","affiliation":[{"name":"KemPharm, Inc, Celebration, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Martin","sequence":"additional","affiliation":[{"name":"KemPharm, Inc, Celebration, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Kelsh","sequence":"additional","affiliation":[{"name":"Altasciences, Overland Park, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley D.","family":"Vince","sequence":"additional","affiliation":[{"name":"Dr. Vince Clinical Research, Overland Park, KS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Barrett","sequence":"additional","affiliation":[{"name":"KemPharm, Inc, Celebration, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-2528"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-017-0409-0"},{"key":"CIT0003","unstructured":"Shearer J. Stimulant use and nonmedical use [Internet]. Silver Spring (MD): FDA; 2020. [cited 2021 Apr 12]. Available from: https:\/\/www.fda.gov\/media\/142732\/download."},{"key":"CIT0004","volume-title":"Key substance use and mental health indicators in the United States: results from the 2018 national survey on drug use and health (HHS publication no. PEP19-5068, NSDUH series H-54) [Internet]","author":"Substance Abuse and Mental Health Services Administration.","year":"2019"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1136\/fmch-2020-000374"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2016.12.008"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v02n0502"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1186\/2193-1801-3-286"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7006a4"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2019.06.012"},{"key":"CIT0011","volume-title":"Prescription stimulants drugfacts [Internet]","author":"National Institute on Drug Abuse","year":"2018"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1177\/1087054719843182"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1177\/1087054713493321"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1177\/1087054712468486"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1177\/1087054720943283"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1080\/10550887.2018.1512825"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.10.1501"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.631792"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000624"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1991.tb01754.x"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1177\/0091270010375956"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1097\/jcp.0b013e3181515205"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1177\/0091270007308615"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.3.387"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2003.08.013"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001507"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(91)90083-D"},{"key":"CIT0028","volume-title":"Drug approval package: AZSTARYS (serdexmethylphenidate and dexmethylphenidate)","author":"Center for Drug Evaluation and Research","year":"2021"},{"key":"CIT0029","unstructured":"Shram MJ, Guenther S, Mickle TC, et\u00a0al. Assessment of the intravenous abuse potential of serdexmethylphenidate (SDX), a novel, investigational prodrug of D-methylphenidate: evidence from nonclinical and clinical studies. Poster presented at: 57th annual meeting of the american college of neuropsychopharmacology (ACNP); 2018 Dec 9\u201313; Hollywood, FL."},{"key":"CIT0030","unstructured":"Guidance document: assessment of abuse potential of drugs, January 2017 [Internet]. Silver Spring (MD): FDA; 2020. [cited 2021 Nov 18]. Available from https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/assessment-abuse-potential-drugs."},{"key":"CIT0031","unstructured":"Braeckman R, Guenther S, Mickle TC, et\u00a0al. Dose-finding study of abuse-related effects of intranasal d-methylphenidate in recreational stimulant abusers. Poster presented at: Annual meeting of children and adults with ADHD (CHADD); 2018 Nov 8\u201311; St. Louis, MO."},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1971122part1245"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31825d380d"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1080\/10543406.2011.616972"},{"key":"CIT0035","unstructured":"Center for Drug Evaluation and Research. Drug approval package: CONCERTA (methylphenidate HCl) extended-release tablets. Silver Spring (MD): FDA; 2000. [updated 2001 June 18; cited 2021 Nov 18]. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2000\/21-121_Concerta.cfm."},{"key":"CIT0036","unstructured":"Drug Enforcement Administration. 21 CFR Part 1308, schedules of controlled substances: placement of serdexmethylphenidate in schedule IV. Washington (DC): US Department of Justice; 2021. [cited 2021 Nov 18]. Available from: https:\/\/www.deadiversion.usdoj.gov\/fed_regs\/rules\/2021\/fr0507_3.htm."},{"key":"CIT0037","volume-title":"Poster presented at: The American Professional Society of ADHD and Related Disorders (APSARD) Annual Conference","author":"Guenther S","year":"2021"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(03)00131-5"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e328363d1c4"}],"container-title":["Current Medical Research and Opinion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/03007995.2022.2076474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T13:46:13Z","timestamp":1657028773000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/03007995.2022.2076474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,3]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7,3]]}},"alternative-id":["10.1080\/03007995.2022.2076474"],"URL":"https:\/\/doi.org\/10.1080\/03007995.2022.2076474","relation":{},"ISSN":["0300-7995","1473-4877"],"issn-type":[{"value":"0300-7995","type":"print"},{"value":"1473-4877","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,3]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=icmo20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=icmo20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}