{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:11:51Z","timestamp":1777353111778,"version":"3.51.4"},"reference-count":53,"publisher":"Informa UK Limited","issue":"10","funder":[{"name":"Chinese National Key Technology R&D Program, Ministry of Science and Technology","award":["2022YFC2504600"],"award-info":[{"award-number":["2022YFC2504600"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2021-I2M-1-005"],"award-info":[{"award-number":["2021-I2M-1-005"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2022-I2M-1-004"],"award-info":[{"award-number":["2022-I2M-1-004"]}]},{"name":"CAMS Innovation Fund for Medical Sciences","award":["2023-I2M-2-005"],"award-info":[{"award-number":["2023-I2M-2-005"]}]},{"name":"The Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences","award":["2021-PT320-002"],"award-info":[{"award-number":["2021-PT320-002"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2025-PUMCH-D-001"],"award-info":[{"award-number":["2025-PUMCH-D-001"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-B-013"],"award-info":[{"award-number":["2022-PUMCH-B-013"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Current Medical Research and Opinion"],"published-print":{"date-parts":[[2025,10,3]]},"DOI":"10.1080\/03007995.2025.2580761","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T08:36:21Z","timestamp":1761640581000},"page":"1993-2004","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":2,"title":["Clinical characteristics of inadequate response to csDMARDs and bDMARDs in patients with rheumatoid arthritis: a cross-sectional, large cohort, real-world practice study"],"prefix":"10.1080","volume":"41","author":[{"given":"Shihan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College","place":["Beijing, PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiuliang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinping","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengtao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Beijing, PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204627"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker370"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-021-01905-w"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215920"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev014"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.218"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22160"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210715"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae544"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223356"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22759"},{"issue":"2","key":"e_1_3_5_13_1","first-page":"227","article-title":"Efficacy and safety of certolizumab pegol in combination with methotrexate in methotrexate-inadequate responder Chinese patients with active rheumatoid arthritis: 24-week results from a randomised, double-blind, placebo-controlled phase 3 study","volume":"37","author":"Bi L","year":"2019","unstructured":"Bi L, Li Y, He L, et al. Efficacy and safety of certolizumab pegol in combination with methotrexate in methotrexate-inadequate responder Chinese patients with active rheumatoid arthritis: 24-week results from a randomised, double-blind, placebo-controlled phase 3 study. Clin Exp Rheumatol. 2019;37(2):227\u2013234.","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.4c00067"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2018.1553265"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta22660"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.111171"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22943"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2033-5"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken002"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21768"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes184"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.084715"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-3003-1"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.2478\/rir-2022-0033"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138461"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-019-04684-1"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213035"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090838"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200001)43:1<22::AID-ANR4>3.0.CO;2-9"},{"issue":"2","key":"e_1_3_5_31_1","first-page":"218","article-title":"The effect of age and renal function on the efficacy and toxicity of methotrexate in rheumatoid arthritis","volume":"22","author":"Rheumatoid Arthritis Clinical Trial Archive Group","year":"1995","unstructured":"Rheumatoid Arthritis Clinical Trial Archive Group. The effect of age and renal function on the efficacy and toxicity of methotrexate in rheumatoid arthritis. J Rheumatol. 1995;22(2):218\u2013223.","journal-title":"J Rheumatol"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110169"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.139212"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10135"},{"issue":"2","key":"e_1_3_5_35_1","first-page":"248","article-title":"Patient, disease, and therapy-related factors that influence discontinuation of disease-modifying antirheumatic drugs: a population-based incidence cohort of patients with rheumatoid arthritis","volume":"33","author":"Maradit-Kremers H","year":"2006","unstructured":"Maradit-Kremers H, Nicola PJ, Crowson CS, et al. Patient, disease, and therapy-related factors that influence discontinuation of disease-modifying antirheumatic drugs: a population-based incidence cohort of patients with rheumatoid arthritis. J Rheumatol. 2006;33(2):248\u2013255. .","journal-title":"J Rheumatol"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100670200008"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S282249"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab583"},{"issue":"1","key":"e_1_3_5_39_1","first-page":"13","article-title":"Chinese consensus on the prevention and treatment of glucocorticoid induced osteoporosis (2020)","volume":"60","year":"2021","unstructured":"Chinese consensus on the prevention and treatment of glucocorticoid induced osteoporosis (2020). Zhonghua Nei Ke Za Zhi. 2021;60(1):13\u201321.","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-010-0366-7"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.140129"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110610"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.11.007"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-225014"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-025-03543-6"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40904"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.24875\/RIC.18002474"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2907"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.148759"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2023-003918"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2023-004037"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2023.100925"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae486"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2024-004278"}],"container-title":["Current Medical Research and Opinion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/03007995.2025.2580761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T03:59:15Z","timestamp":1768190355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/03007995.2025.2580761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,3]]},"references-count":53,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,3]]}},"alternative-id":["10.1080\/03007995.2025.2580761"],"URL":"https:\/\/doi.org\/10.1080\/03007995.2025.2580761","relation":{},"ISSN":["0300-7995","1473-4877"],"issn-type":[{"value":"0300-7995","type":"print"},{"value":"1473-4877","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,3]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=icmo20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=icmo20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}