{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:55:03Z","timestamp":1792785303328,"version":"4.5.0"},"reference-count":34,"publisher":"Informa UK Limited","issue":"5","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"New Zealand Rheumatology Association"},{"DOI":"10.13039\/501100001511","name":"Auckland Medical Research Foundation","doi-asserted-by":"publisher","award":["1117012"],"award-info":[{"award-number":["1117012"]}],"id":[{"id":"10.13039\/501100001511","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["16\/022 and 20\/199"],"award-info":[{"award-number":["16\/022 and 20\/199"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Connective Tissue Research"],"published-print":{"date-parts":[[2023,9,3]]},"DOI":"10.1080\/03008207.2023.2214249","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T09:25:51Z","timestamp":1683883551000},"page":"457-468","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":5,"title":["Concentration-dependent effects of leptin on osteoarthritis-associated changes in phenotype of human chondrocytes"],"prefix":"10.1080","volume":"64","author":[{"given":"Julia GB","family":"Primrose","sequence":"first","affiliation":[{"name":"University of Auckland","place":["Auckland, New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lekha","family":"Jain","sequence":"additional","affiliation":[{"name":"University of Auckland","place":["Auckland, New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M","family":"Bolam","sequence":"additional","affiliation":[{"name":"University of Auckland","place":["Auckland, New Zealand"]},{"name":"University of Auckland","place":["Auckland, New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Paul","family":"Monk","sequence":"additional","affiliation":[{"name":"University of Auckland","place":["Auckland, New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob T","family":"Munro","sequence":"additional","affiliation":[{"name":"University of Auckland","place":["Auckland, New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[{"name":"University of Auckland","place":["Auckland, New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raewyn C","family":"Poulsen","sequence":"additional","affiliation":[{"name":"University of Auckland","place":["Auckland, New Zealand"]},{"name":"University of Auckland","place":["Auckland, New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"e_1_3_3_2_1","unstructured":"Wittenauer R Smith L Aden K Priority medicines for Europe and the world \u201cA public health approach to innovation\u201d update on 2004 background paper 6.12 osteoarthritis. 2013."},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42089"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.135"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39707"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14553"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.04.002"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047860"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.01.009"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-013-1982-6"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes422"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-018-3761-x"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2017.1385605"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10336"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200372"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3048"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-017-1601-6"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b01168"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(10)60038-6"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26593"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.05.009"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052533"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1112-0"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-018-0494-1"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2018.1540493"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2012.01513.x"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107577"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1419699112"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10060886"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0791"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.02.644"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27311"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.000786"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocarto.2020.100087"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.04.014"}],"container-title":["Connective Tissue Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/03008207.2023.2214249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T06:21:04Z","timestamp":1776666064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/03008207.2023.2214249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,17]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9,3]]}},"alternative-id":["10.1080\/03008207.2023.2214249"],"URL":"https:\/\/doi.org\/10.1080\/03008207.2023.2214249","relation":{},"ISSN":["0300-8207","1607-8438"],"issn-type":[{"value":"0300-8207","type":"print"},{"value":"1607-8438","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,17]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=icts20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=icts20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}