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In healthy individuals, appropriate chemoreflex responses are triggered by acute activation of the carotid body \u2010 the principal chemosensory organ in mammals. However, the aberrant chronic activation of the carotid body can drive the elevated sympathetic activity underlying cardio\u2010respiratory diseases such as hypertension, diabetes and heart failure. Carotid body resection induces intolerable side effects and so understanding how to modulate carotid body output without removing it, and whilst maintaining the physiological chemoreflex response, represents the next logical next step in the development of effective clinical interventions. By definition, excessive carotid body output must result from altered intra\u2010carotid body inter\u2010cellular communication. Alongside the canonical synaptic transmission from glomus cells to petrosal afferents, many other modes of information exchange in the carotid body have been identified, for example bidirectional signalling between type I and type II cells via ATP\u2010induced ATP release, as well as electrical communication via gap junctions. Thus, herein we review the carotid body as an integrated circuit, discussing a variety of different inter\u2010cellular signalling mechanisms and highlighting those that are potentially relevant to its pathological hyperactivity in disease with the aim of identifying novel therapeutic targets.<\/jats:p>","DOI":"10.1080\/03036758.2022.2079681","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T20:28:40Z","timestamp":1653942520000},"page":"332-361","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["Intra\u2010carotid body inter\u2010cellular communication"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2457-248X","authenticated-orcid":false,"given":"Liam P.","family":"Argent","sequence":"first","affiliation":[{"name":"Manaaki Manawa \u2013 the Centre for Heart Research Department of Physiology University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aabharika","family":"Bose","sequence":"additional","affiliation":[{"name":"Manaaki Manawa \u2013 the Centre for Heart Research Department of Physiology University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7410-2913","authenticated-orcid":false,"given":"Julian F. 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